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H3-4 and BIRC5
Data Source:
BioGRID
(unspecified method)
H3-4
BIRC5
Description
H3.4 histone
baculoviral IAP repeat containing 5
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleosome
Nucleus
Nucleoplasm
Extracellular Exosome
Nuclear Chromosome
Chromosome, Centromeric Region
Condensed Chromosome Kinetochore
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Spindle Microtubule
Midbody
Chromosome Passenger Complex
Molecular Function
DNA Binding
Protein Binding
Protein Heterodimerization Activity
Protein Binding
Microtubule Binding
Enzyme Binding
Small GTPase Binding
Identical Protein Binding
Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
Metal Ion Binding
Chaperone Binding
Biological Process
Double-strand Break Repair Via Nonhomologous End Joining
Nucleosome Assembly
Telomere Capping
Protein Phosphorylation
Apoptotic Process
Chromosome Segregation
Sensory Perception Of Sound
Positive Regulation Of Cell Population Proliferation
Cytokine-mediated Signaling Pathway
Protein-containing Complex Localization
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Transcription, DNA-templated
Cell Division
Regulation Of Cell Cycle
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
Condensation of Prophase Chromosomes
DNA Damage/Telomere Stress Induced Senescence
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
G2/M DNA damage checkpoint
Meiotic recombination
Inhibition of DNA recombination at telomere
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
SUMOylation of DNA replication proteins
RHO GTPases Activate Formins
Interleukin-4 and Interleukin-13 signaling
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
Mitotic Prometaphase
Neddylation
EML4 and NUDC in mitotic spindle formation
Drugs
Reserpine
Berberine
LY2181308
Diseases
GWAS
Blood trace element (Se levels) (
23720494
)
Periodontitis (Mean PAL) (
24024966
)
Interacting Genes
198 interacting genes:
ADNP
AFF1
AHDC1
ANP32A
ASF1A
ASH2L
ATAD2
AURKA
AURKB
BIRC5
BMI1
BPTF
BRD7
C17orf49
CBX1
CBX2
CBX3
CBX4
CBX5
CBX7
CBX8
CDYL
CDYL2
CHAF1A
CHAF1B
CHAMP1
CHD1
CHD4
CHD6
CHUK
COPRS
CREBBP
CTBP1
CTBP2
DCAF1
DEK
DIDO1
DNMT1
DOT1L
DPF2
DPY30
DYRK2
EGFR
EHMT1
EHMT2
EMSY
EP300
ERAP1
EZH2
FOXA1
GADD45A
GATAD1
GLYR1
GTF3C4
HAT1
HDAC1
HDAC2
HDAC8
HIRIP3
HMGXB4
HNRNPA1
HNRNPA2B1
HNRNPAB
HNRNPK
HNRNPL
HNRNPR
HPF1
ING2
ING4
IRAK1
JADE2
JADE3
JAK1
JAK2
KAT2A
KAT2B
KAT5
KAT6A
KDM1A
KDM1B
KDM2A
KDM3B
KDM5A
KDM5D
KDM6A
KIF2A
KIF2C
KMT2A
KMT2C
KPNA1
LRIF1
LRWD1
MBD3
MCM2
MCM7
MDM2
MEN1
MGA
MIER1
MLLT1
MORF4L1
MSL3
MTA1
MTA2
MYB
NAP1L4
NASP
NBN
NCL
NCOA2
NCOA3
NOC2L
NONO
NPM1
NSD1
NSD2
ORC2
ORC3
ORC4
ORC5
PARP1
PARP2
PCGF6
PHC2
PHC3
PHF12
PHF7
PHF8
PHRF1
PIM1
POGZ
PPIB
PPM1G
PRDM2
PRKCA
PRMT5
PTBP1
PTMA
RAG1
RBBP4
RBBP5
RBBP7
RBP5
RCOR1
RING1
RIPPLY1
RNF2
RPS6KA3
RPS6KA5
RREB1
SAP30
SET
SETD2
SETD7
SETDB1
SFPQ
SGF29
SIN3A
SIN3B
SMN1
SMNDC1
SMYD3
SUPT20H
SUPT3H
SUV39H1
SUZ12
TADA1
TADA3
TAF1
TAF10
TAF11
TAF12
TAF13
TAF15
TAF1A
TAF2
TAF3
TAF4
TAF4B
TAF5
TAF5L
TAF6
TAF6L
TAF7
TAF8
TAF9
TAF9B
TBP
TCF19
TDRD3
TNPO1
TRPM7
UHRF1
WDR5
ZMYM4
ZMYND11
ZNF217
ZNF516
25 interacting genes:
AURKA
AURKB
AURKC
BIRC2
BIRC3
BIRC6
CASP3
CASP7
CASP9
CCDC85B
CDCA8
CDK1
CDK4
DIABLO
EVI5
FBXL7
H3-4
H3C14
HSP90AA1
INCENP
KCNJ6
RAN
RASA1
XIAP
XPO1
Entrez ID
8290
332
HPRD ID
04156
04520
Ensembl ID
ENSG00000168148
ENSG00000089685
Uniprot IDs
Q16695
A0A0B4J1S3
H3BLT4
O15392
PDB IDs
2V1D
2YBP
2YBS
3A6N
3T6R
4V2V
4V2W
6OIE
6WAT
6WAU
1E31
1F3H
1XOX
2QFA
2RAW
2RAX
3UEC
3UED
3UEE
3UEF
3UEG
3UEH
3UEI
3UIG
3UIH
3UII
3UIJ
3UIK
4A0I
4A0J
4A0N
6SHO
6YIE
6YIF
6YIH
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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