TLR10 and LUC7L3

Data Source:
HPRD (two hybrid)

		TLR10	LUC7L3
Description		toll like receptor 10	LUC7 like 3 pre-mRNA splicing factor
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane	Nucleus Nucleoplasm U1 SnRNP Nuclear Speck U2-type Prespliceosome
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Signaling Receptor Activity Identical Protein Binding NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating	DNA Binding RNA Binding MRNA Binding Protein Binding
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Immune Response Toll-like Receptor 10 Signaling Pathway Innate Immune Response Positive Regulation Of Inflammatory Response	MRNA Splice Site Selection RNA Splicing
Pathways		Toll Like Receptor 10 (TLR10) Cascade IRAK4 deficiency (TLR5) MyD88 cascade initiated on plasma membrane
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29785011) Allergic rhinitis ( 30013184) Allergic sensitization ( 23817571) Asthma ( 31361310 31959851 31619474) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Diabetes in response to antihypertensive drug treatment (treatment strategy interaction) ( 27670767) Endometriosis or endometrial cancer (pleiotropy) ( 29608257) Helicobacter pylori serologic status ( 23652523) Limited cutaneous systemic scleroderma ( 29293537) Self-reported allergy ( 23817569) Systemic sclerosis (anti-topoisomerase-positive) ( 29293537)	Mild to moderate chronic kidney disease ( 31178898)
Interacting Genes		12 interacting genes: CAT ECH1 F8A1 FLNA FUT7 GLDC LUC7L3 MYD88 PTPN6 TLR1 TLR2 TRIM54	9 interacting genes: CLK1 ITSN2 MLH1 RNPS1 SRPK1 SRPK2 SRSF1 TLR10 YWHAG
Entrez ID		81793	51747
HPRD ID		05884	16759
Ensembl ID		ENSG00000174123	ENSG00000108848
Uniprot IDs		A0A024R9W4 Q9BXR5	A8K3C5 J3KPP4 O95232 Q86Y74
PDB IDs		2J67
Enriched GO Terms of Interacting Partners?
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