TLR10 and GLDC

Data Source:
HPRD (two hybrid)

		TLR10	GLDC
Description		toll like receptor 10	glycine decarboxylase
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane	Nucleoplasm Mitochondrion Mitochondrial Matrix Plasma Membrane Glycine Cleavage Complex
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Signaling Receptor Activity Identical Protein Binding NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating	Glycine Dehydrogenase (decarboxylating) Activity Electron Transfer Activity Glycine Binding Lyase Activity Enzyme Binding Pyridoxal Phosphate Binding Protein Homodimerization Activity Pyridoxal Binding
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Immune Response Toll-like Receptor 10 Signaling Pathway Innate Immune Response Positive Regulation Of Inflammatory Response	Glycine Catabolic Process Glycine Decarboxylation Via Glycine Cleavage System Electron Transport Chain Response To Methylamine Protein-containing Complex Assembly Response To Lipoic Acid
Pathways		Toll Like Receptor 10 (TLR10) Cascade IRAK4 deficiency (TLR5) MyD88 cascade initiated on plasma membrane	Glycine degradation
Drugs			Pyridoxal phosphate
Diseases			Nonketotic hyperglycinemia; Glycine encephalopathy (GCE)
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29785011) Allergic rhinitis ( 30013184) Allergic sensitization ( 23817571) Asthma ( 31361310 31959851 31619474) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Diabetes in response to antihypertensive drug treatment (treatment strategy interaction) ( 27670767) Endometriosis or endometrial cancer (pleiotropy) ( 29608257) Helicobacter pylori serologic status ( 23652523) Limited cutaneous systemic scleroderma ( 29293537) Self-reported allergy ( 23817569) Systemic sclerosis (anti-topoisomerase-positive) ( 29293537)	Alanine transaminase levels ( 29403010) Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Glycine levels ( 31070104 30837465) Height ( 31562340) Metabolite levels ( 23823483) Metabolite levels (small molecules and protein measures) ( 27005778) Overall survival in osteosarcoma ( 29210060) Periodontal microbiota ( 22699663) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		12 interacting genes: CAT ECH1 F8A1 FLNA FUT7 GLDC LUC7L3 MYD88 PTPN6 TLR1 TLR2 TRIM54	1 interacting genes: TLR10
Entrez ID		81793	2731
HPRD ID		05884	01996
Ensembl ID		ENSG00000174123	ENSG00000178445
Uniprot IDs		A0A024R9W4 Q9BXR5	P23378
PDB IDs		2J67	6I33 6I34 6I35
Enriched GO Terms of Interacting Partners?
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