PLEKHF2 and TP53BP2

Data Source:
BioGRID (two hybrid)

		PLEKHF2	TP53BP2
Description		pleckstrin homology and FYVE domain containing 2	tumor protein p53 binding protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Transport Vesicle Early Endosome Membrane	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Cell Junction Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Phosphatidylinositol Binding Metal Ion Binding	P53 Binding Protein Binding SH3 Domain Binding Identical Protein Binding NF-kappaB Binding
	Biological Process	Protein Transport	Cell Cycle Signal Transduction Regulation Of Apoptotic Process Negative Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Neuron Death Regulation Of Signal Transduction By P53 Class Mediator
Pathways			Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors
Drugs
Diseases
GWAS		Radiation response ( 20923822)	Triptolide cytotoxicity ( 26121980)
Interacting Genes		168 interacting genes: ABCG4 ACY3 ADAP1 AIDA AIMP2 ANO9 APP APPL1 ARID4B ARL14EP ASPH BARHL2 BCAS2 BCAS3 BEND7 BLOC1S6 BOD1 BRD7 BSCL2 C11orf45 C1orf35 C3 CAVIN2 CBX8 CCDC146 CCDC172 CCDC25 CCDC85B CDC20B CEP44 CERK CGGBP1 CHCHD2 CHIC2 COX5B CRYBA1 DAZAP2 DMRT3 DNAAF11 DOCK2 DOCK3 DPPA4 DRAP1 DTX2 DUSP4 DUT EIF3C EML2 EXOC7 FAH FBXO28 FBXW5 FGF13 FHL3 FLNA FRMD8 GAGE12G GAGE2E GEM GFER GLUL GNMT GPBP1 GPBP1L1 GRAMD4 GTPBP2 HEBP2 HSPB7 INO80 KCNAB3 KRTAP10-10 KRTAP5-4 L3MBTL3 LDOC1 MAGI2 MAP2K1 MAX MBIP MBP MEAF6 MFAP1 MIDN MPP4 MRI1 NDUFA5 NFIA NONO NPM2 NSD2 NUDT2 NUTM1 P2RX7 PACSIN1 PAK1IP1 PDK4 PIK3R3 PPCDC PPP1R18 PRDM14 PRKAG1 PRKAR1A PRPSAP1 PTPN3 PWWP2A RAB28 RABAC1 RADX RARA RASGEF1B RGS10 RGS8 RPAP2 RPE RPRM RPS21 RSPO2 RTN1 RTN3 RTN4 S100A1 S100A13 SAMD11 SCYL1 SEC14L4 SEPTIN2 SEPTIN5 SEPTIN6 SETBP1 SFN SNRNP35 SOST SPATA24 SPEF1 SPON2 STAMBPL1 SYT16 TBCEL TBX3 TCEANC THAP10 THG1L TNFAIP8 TNFAIP8L1 TP53BP2 TRAF6 TRAM1L1 TRAPPC3 TRIAP1 TRIM22 TSC22D3 TTC9C TXNL4B UBE2Z UGP2 USF1 XCR1 XRN2 YIF1A YY1 ZBTB6 ZDHHC24 ZFYVE26 ZNF165 ZNF250 ZNF263 ZNF398 ZNF439 ZNF581	122 interacting genes: ADAMTS12 APP APPL1 ARHGEF6 ATPAF2 ATXN7 AXIN1 BAG3 BAIAP2 BCAS2 BCL2 BCL2L1 CCDC13 CCDC57 CCDC85A CCDC92 CDC5L CEP55 CEP95 CGN CRK CSNK2B CWF19L2 DCUN1D1 DDX6 DIRAS1 EEF1A1 EFHC1 ELOA GCC1 GEM GFAP GOLGA1 GPS2 GRB2 H2BC4 H2BC9 HHEX HIF1AN HNRNPUL1 HSF2BP INSYN2A IQUB KDM1A KIF5A LHX4 LMNB1 LMNB2 LMO4 MAGI1 MAPK8IP2 MOS MRPL20 MTMR14 MTURN NAE1 NDC80 NEDD4 NFKB1 NHSL2 NUTM1 OTUB2 PHF1 PIBF1 PLEKHF2 PLEKHN1 PLK1 POLR2L PPHLN1 PPP1CA PPP1CB PPP1CC PRAM1 PRKAB2 PRPF31 PTN RALBP1 RASAL3 RASSF10 RASSF8 RELA RGMA RXRB SCNM1 SETD5 SH3KBP1 SH3RF1 SHTN1 SIAH1 SIAH2 SUMO2 SUMO3 TANK TBC1D22B TCL1A TP53 TRAF4 TROAP TSGA10 TXLNA TYK2 UBASH3A UBASH3B UBE3A UBTD1 UNC119 USP4 UTP14A WWP1 WWP2 YAP1 YES1 YOD1 YWHAG YWHAQ ZBTB4 ZFP91 ZGPAT ZNF26 ZNF438 ZNF552 ZNF575
Entrez ID		79666	7159
HPRD ID		15147	11803
Ensembl ID		ENSG00000175895	ENSG00000143514
Uniprot IDs		Q9H8W4	Q13625
PDB IDs			1YCS 2UWQ 4A63 4IRV 6GHM 6HKP
Enriched GO Terms of Interacting Partners?
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