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TP53BP2 and NDC80
Data Source:
BioGRID
(two hybrid)
TP53BP2
NDC80
Description
tumor protein p53 binding protein 2
NDC80 kinetochore complex component
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Cell Junction
Perinuclear Region Of Cytoplasm
Chromosome, Centromeric Region
Kinetochore
Condensed Chromosome Kinetochore
Condensed Nuclear Chromosome Kinetochore
Condensed Nuclear Chromosome Outer Kinetochore
Nucleus
Nucleoplasm
Centrosome
Cytosol
Membrane
Ndc80 Complex
Molecular Function
P53 Binding
Protein Binding
SH3 Domain Binding
Identical Protein Binding
NF-kappaB Binding
Protein Binding
Identical Protein Binding
Biological Process
Cell Cycle
Signal Transduction
Regulation Of Apoptotic Process
Negative Regulation Of Cell Cycle
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Positive Regulation Of Execution Phase Of Apoptosis
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Positive Regulation Of Neuron Death
Regulation Of Signal Transduction By P53 Class Mediator
Mitotic Sister Chromatid Segregation
Establishment Of Mitotic Spindle Orientation
Mitotic Cell Cycle
Mitotic Spindle Organization
Chromosome Segregation
Attachment Of Spindle Microtubules To Kinetochore
Centrosome Duplication
Cell Division
Metaphase Plate Congression
Attachment Of Mitotic Spindle Microtubules To Kinetochore
Kinetochore Organization
Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Positive Regulation Of Protein Localization To Kinetochore
Pathways
Activation of PUMA and translocation to mitochondria
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
TP53 Regulates Transcription of Death Receptors and Ligands
Regulation of TP53 Activity through Association with Co-factors
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS
Triptolide cytotoxicity (
26121980
)
Metabolite levels (
23823483
)
Response to cognitive-behavioural therapy in major depressive disorder (
31123309
)
Interacting Genes
122 interacting genes:
ADAMTS12
APP
APPL1
ARHGEF6
ATPAF2
ATXN7
AXIN1
BAG3
BAIAP2
BCAS2
BCL2
BCL2L1
CCDC13
CCDC57
CCDC85A
CCDC92
CDC5L
CEP55
CEP95
CGN
CRK
CSNK2B
CWF19L2
DCUN1D1
DDX6
DIRAS1
EEF1A1
EFHC1
ELOA
GCC1
GEM
GFAP
GOLGA1
GPS2
GRB2
H2BC4
H2BC9
HHEX
HIF1AN
HNRNPUL1
HSF2BP
INSYN2A
IQUB
KDM1A
KIF5A
LHX4
LMNB1
LMNB2
LMO4
MAGI1
MAPK8IP2
MOS
MRPL20
MTMR14
MTURN
NAE1
NDC80
NEDD4
NFKB1
NHSL2
NUTM1
OTUB2
PHF1
PIBF1
PLEKHF2
PLEKHN1
PLK1
POLR2L
PPHLN1
PPP1CA
PPP1CB
PPP1CC
PRAM1
PRKAB2
PRPF31
PTN
RALBP1
RASAL3
RASSF10
RASSF8
RELA
RGMA
RXRB
SCNM1
SETD5
SH3KBP1
SH3RF1
SHTN1
SIAH1
SIAH2
SUMO2
SUMO3
TANK
TBC1D22B
TCL1A
TP53
TRAF4
TROAP
TSGA10
TXLNA
TYK2
UBASH3A
UBASH3B
UBE3A
UBTD1
UNC119
USP4
UTP14A
WWP1
WWP2
YAP1
YES1
YOD1
YWHAG
YWHAQ
ZBTB4
ZFP91
ZGPAT
ZNF26
ZNF438
ZNF552
ZNF575
64 interacting genes:
AMOTL2
ATF4
ATP5PO
ATP6V1D
AURKA
AURKB
BLOC1S6
CAGE1
CALCOCO1
CCDC136
CCHCR1
CCNH
CCNK
CENPH
CEP63
CKAP5
EPS15L1
EXOC8
FAM9C
GOLGA2
HAUS1
HGS
HIP1R
IFT20
INPP1
KIFC3
KLC3
KLHL12
KRT27
KRT6B
KRT75
LNX1
MAD1L1
MAD2L1
MFAP1
MIS12
NDE1
NDEL1
NEK2
NUF2
PCM1
PFDN1
PPP1R13B
PSMC2
RB1
RUFY4
SFR1
SGF29
SKA1
SMC1A
SPC25
STX11
TFIP11
THOC7
TNIP1
TOM1L1
TP53BP2
TXLNA
USHBP1
VPS52
WASHC1
WASHC3
ZNF655
ZWINT
Entrez ID
7159
10403
HPRD ID
11803
06277
Ensembl ID
ENSG00000143514
ENSG00000080986
Uniprot IDs
Q13625
A8K031
O14777
PDB IDs
1YCS
2UWQ
4A63
4IRV
6GHM
6HKP
2IGP
2VE7
3IZ0
Enriched GO Terms of Interacting Partners
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