PLEKHF2 and SOST

Data Source:
BioGRID (two hybrid)

		PLEKHF2	SOST
Description		pleckstrin homology and FYVE domain containing 2	sclerostin
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Transport Vesicle Early Endosome Membrane	Extracellular Region Extracellular Space Golgi Apparatus Protein-containing Complex Collagen-containing Extracellular Matrix
	Molecular Function	Protein Binding Phosphatidylinositol Binding Metal Ion Binding	Protein Binding Transcription Factor Binding Heparin Binding BMP Binding
	Biological Process	Protein Transport	Ossification Response To Mechanical Stimulus Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Ossification Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Transcription, DNA-templated Cellular Response To Parathyroid Hormone Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways			TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists
Drugs			Romosozumab
Diseases			SOST related disorders, including: Sclerosteosis ; Endosteal hyperostosis, van Buchem type
GWAS		Radiation response ( 20923822)	Bone mineral density (hip) ( 26733130 19079262) Bone mineral density (spine) ( 26733130) Eosinophil counts ( 27863252) Femoral neck bone mineral density ( 29499414 22504420) Fractures ( 30158200 30598549) HDL cholesterol ( 25961943 27036123) Heel bone mineral density ( 30598549 28869591) Lumbar spine bone mineral density ( 29499414) Sum eosinophil basophil counts ( 27863252) Triglycerides ( 25961943)
Interacting Genes		168 interacting genes: ABCG4 ACY3 ADAP1 AIDA AIMP2 ANO9 APP APPL1 ARID4B ARL14EP ASPH BARHL2 BCAS2 BCAS3 BEND7 BLOC1S6 BOD1 BRD7 BSCL2 C11orf45 C1orf35 C3 CAVIN2 CBX8 CCDC146 CCDC172 CCDC25 CCDC85B CDC20B CEP44 CERK CGGBP1 CHCHD2 CHIC2 COX5B CRYBA1 DAZAP2 DMRT3 DNAAF11 DOCK2 DOCK3 DPPA4 DRAP1 DTX2 DUSP4 DUT EIF3C EML2 EXOC7 FAH FBXO28 FBXW5 FGF13 FHL3 FLNA FRMD8 GAGE12G GAGE2E GEM GFER GLUL GNMT GPBP1 GPBP1L1 GRAMD4 GTPBP2 HEBP2 HSPB7 INO80 KCNAB3 KRTAP10-10 KRTAP5-4 L3MBTL3 LDOC1 MAGI2 MAP2K1 MAX MBIP MBP MEAF6 MFAP1 MIDN MPP4 MRI1 NDUFA5 NFIA NONO NPM2 NSD2 NUDT2 NUTM1 P2RX7 PACSIN1 PAK1IP1 PDK4 PIK3R3 PPCDC PPP1R18 PRDM14 PRKAG1 PRKAR1A PRPSAP1 PTPN3 PWWP2A RAB28 RABAC1 RADX RARA RASGEF1B RGS10 RGS8 RPAP2 RPE RPRM RPS21 RSPO2 RTN1 RTN3 RTN4 S100A1 S100A13 SAMD11 SCYL1 SEC14L4 SEPTIN2 SEPTIN5 SEPTIN6 SETBP1 SFN SNRNP35 SOST SPATA24 SPEF1 SPON2 STAMBPL1 SYT16 TBCEL TBX3 TCEANC THAP10 THG1L TNFAIP8 TNFAIP8L1 TP53BP2 TRAF6 TRAM1L1 TRAPPC3 TRIAP1 TRIM22 TSC22D3 TTC9C TXNL4B UBE2Z UGP2 USF1 XCR1 XRN2 YIF1A YY1 ZBTB6 ZDHHC24 ZFYVE26 ZNF165 ZNF250 ZNF263 ZNF398 ZNF439 ZNF581	1 interacting genes: PLEKHF2
Entrez ID		79666	50964
HPRD ID		15147	05762
Ensembl ID		ENSG00000175895	ENSG00000167941
Uniprot IDs		Q9H8W4	Q9BQB4
PDB IDs			2K8P 3SOV 6L6R
Enriched GO Terms of Interacting Partners?
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