CALCA and RAMP1

Data Source:
HPRD (in vivo)

		CALCA	RAMP1
Description		calcitonin related polypeptide alpha	receptor activity modifying protein 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Neuronal Cell Body Terminal Bouton	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Receptor Complex Amylin Receptor Complex 1 CGRP Receptor Complex
	Molecular Function	Hormone Activity Protein Binding Calcitonin Receptor Binding Identical Protein Binding	Calcitonin Gene-related Peptide Receptor Activity Protein Binding Coreceptor Activity Amylin Receptor Activity Calcitonin Gene-related Peptide Binding
	Biological Process	Artery Vasodilation Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Monocyte Chemotaxis Inflammatory Response G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Embryo Implantation Aging Feeding Behavior Regulation Of Heart Contraction Response To Heat Negative Regulation Of Ossification Activation Of Protein Kinase Activity Cellular Protein Metabolic Process Negative Regulation Of Bone Resorption Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Smooth Muscle Contraction Response To Pain Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Cellular Response To Tumor Necrosis Factor Cellular Response To Nerve Growth Factor Stimulus	Angiogenesis Calcium Ion Transport Intracellular Protein Transport G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Protein Transport Receptor Internalization Positive Regulation Of Protein Binding Cellular Response To Hormone Stimulus Positive Regulation Of Protein Glycosylation Protein Localization To Plasma Membrane Amylin Receptor Signaling Pathway Calcitonin Gene-related Peptide Receptor Signaling Pathway
Pathways		G alpha (s) signalling events Calcitonin-like ligand receptors ADORA2B mediated anti-inflammatory cytokines production Amyloid fiber formation G alpha (s) signalling events Calcitonin-like ligand receptors ADORA2B mediated anti-inflammatory cytokines production	G alpha (s) signalling events Calcitonin-like ligand receptors ADORA2B mediated anti-inflammatory cytokines production
Drugs		Olcegepant Telcagepant Eptinezumab Fremanezumab Galcanezumab	Pramlintide
Diseases
GWAS		Diverticular disease ( 30177863) Vitamin D levels ( 25208829)	Obesity-related traits ( 23251661) Resting metabolic rate ( 28476931)
Interacting Genes		8 interacting genes: ANKRD11 BBS1 BBS4 CALCRL ECE1 NRDC RAMP1 RAMP2	9 interacting genes: CALCA CALCR CALCRL IAPP MAL MS4A13 NKG7 SLC31A2 VIPR1
Entrez ID		796	10267
HPRD ID		00238	05515
Ensembl ID		ENSG00000110680	ENSG00000132329
Uniprot IDs		P01258 P06881	E9PC20 O60894
PDB IDs		1LS7 2JXZ 6E3Y	2YX8 3N7P 3N7R 3N7S 4RWG 5V6Y 6D1U 6E3Y 6UMG 6ZHO 6ZIS
Enriched GO Terms of Interacting Partners?
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