RAMP1 and CALCA

Data Source:
HPRD (in vivo)

		RAMP1	CALCA
Description		receptor activity modifying protein 1	calcitonin related polypeptide alpha
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Receptor Complex Amylin Receptor Complex 1 CGRP Receptor Complex	Extracellular Region Extracellular Space Nucleus Cytoplasm Neuronal Cell Body Terminal Bouton
	Molecular Function	Calcitonin Gene-related Peptide Receptor Activity Protein Binding Coreceptor Activity Amylin Receptor Activity Calcitonin Gene-related Peptide Binding	Hormone Activity Protein Binding Calcitonin Receptor Binding Identical Protein Binding
	Biological Process	Angiogenesis Calcium Ion Transport Intracellular Protein Transport G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Protein Transport Receptor Internalization Positive Regulation Of Protein Binding Cellular Response To Hormone Stimulus Positive Regulation Of Protein Glycosylation Protein Localization To Plasma Membrane Amylin Receptor Signaling Pathway Calcitonin Gene-related Peptide Receptor Signaling Pathway	Artery Vasodilation Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Monocyte Chemotaxis Inflammatory Response G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Embryo Implantation Aging Feeding Behavior Regulation Of Heart Contraction Response To Heat Negative Regulation Of Ossification Activation Of Protein Kinase Activity Cellular Protein Metabolic Process Negative Regulation Of Bone Resorption Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Smooth Muscle Contraction Response To Pain Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Cellular Response To Tumor Necrosis Factor Cellular Response To Nerve Growth Factor Stimulus
Pathways		G alpha (s) signalling events Calcitonin-like ligand receptors ADORA2B mediated anti-inflammatory cytokines production	G alpha (s) signalling events Calcitonin-like ligand receptors ADORA2B mediated anti-inflammatory cytokines production Amyloid fiber formation G alpha (s) signalling events Calcitonin-like ligand receptors ADORA2B mediated anti-inflammatory cytokines production
Drugs		Pramlintide	Olcegepant Telcagepant Eptinezumab Fremanezumab Galcanezumab
Diseases
GWAS		Obesity-related traits ( 23251661) Resting metabolic rate ( 28476931)	Diverticular disease ( 30177863) Vitamin D levels ( 25208829)
Interacting Genes		9 interacting genes: CALCA CALCR CALCRL IAPP MAL MS4A13 NKG7 SLC31A2 VIPR1	8 interacting genes: ANKRD11 BBS1 BBS4 CALCRL ECE1 NRDC RAMP1 RAMP2
Entrez ID		10267	796
HPRD ID		05515	00238
Ensembl ID		ENSG00000132329	ENSG00000110680
Uniprot IDs		E9PC20 O60894	P01258 P06881
PDB IDs		2YX8 3N7P 3N7R 3N7S 4RWG 5V6Y 6D1U 6E3Y 6UMG 6ZHO 6ZIS	1LS7 2JXZ 6E3Y
Enriched GO Terms of Interacting Partners?
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