BAG6 and FZD4

Data Source:
BioGRID (two hybrid)

		BAG6	FZD4
Description		BAG cochaperone 6	frizzled class receptor 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Intracellular Membrane-bounded Organelle Extracellular Exosome BAT3 Complex	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Cell Surface Dendrite Clathrin-coated Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Glutamatergic Synapse
	Molecular Function	Signaling Receptor Binding Protein Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding Ribosome Binding Misfolded Protein Binding Proteasome Binding Ubiquitin-specific Protease Binding	Amyloid-beta Binding Cytokine Receptor Activity G Protein-coupled Receptor Activity Protein Binding Wnt-protein Binding Cytokine Binding PDZ Domain Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity Protein Homodimerization Activity Wnt-activated Receptor Activity Protein-containing Complex Binding Protein Heterodimerization Activity
	Biological Process	Kidney Development Immune Response-activating Cell Surface Receptor Signaling Pathway Chromatin Organization Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Synaptonemal Complex Assembly Spermatogenesis Brain Development Proteasomal Protein Catabolic Process Internal Peptidyl-lysine Acetylation Natural Killer Cell Activation Cell Differentiation Lung Development Ubiquitin-dependent ERAD Pathway Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Proteolysis Regulation Of Embryonic Development Protein Stabilization Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress ER-associated Misfolded Protein Catabolic Process Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of ERAD Pathway Maintenance Of Unfolded Protein Involved In ERAD Pathway Protein Localization To Cytosolic Proteasome Complex Involved In ERAD Pathway	Vasculogenesis G Protein-coupled Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Sensory Perception Of Sound Negative Regulation Of Cell-substrate Adhesion Wnt Signaling Pathway Cytokine-mediated Signaling Pathway Neuron Differentiation Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Locomotion Involved In Locomotory Behavior Substrate Adhesion-dependent Cell Spreading Extracellular Matrix-cell Signaling Non-canonical Wnt Signaling Pathway Progesterone Secretion Positive Regulation Of JUN Kinase Activity Positive Regulation Of Transcription, DNA-templated Positive Regulation Of DNA-binding Transcription Factor Activity Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Membrane Organization Retina Vasculature Morphogenesis In Camera-type Eye Cerebellum Vasculature Morphogenesis Retinal Blood Vessel Morphogenesis Cellular Response To Retinoic Acid Negative Regulation Of Canonical Wnt Signaling Pathway Norrin Signaling Pathway Positive Regulation Of Neuron Projection Arborization Cellular Response To Leukemia Inhibitory Factor
Pathways		Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Class B/2 (Secretin family receptors) Ca2+ pathway Ca2+ pathway Asymmetric localization of PCP proteins Regulation of FZD by ubiquitination WNT5A-dependent internalization of FZD4 Signaling by RNF43 mutants Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases			Familial exudative vitreoretinopathy (FEVR), including: Exudative vitreoretinopathy 1 (EVR1); Exudative vitreoretinopathy2, X-linked (EVR2); Exudative vitreoretinopathy 4 (EVR4); Exudative vitreoretinopathy 5 (EVR5); Norrie disease (ND)
GWAS		Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Height ( 28552196) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Schizophrenia ( 23894747) Small cell lung carcinoma ( 28604730) Smoking status (ever vs never smokers) ( 30643258) Ulcerative colitis ( 28067908)	Hepatocellular carcinoma in hepatitis B infection ( 26870257)
Interacting Genes		118 interacting genes: ACVR1B AMFR AMTN ANTKMT ANXA7 APBB1IP ARPC3 ATN1 ATXN2 B2M C1QA CD93 CDK16 CDK4 CDK5 CDKN1A CDSN CHN2 CILK1 CLU CSNK2B CSTF2 CTAG1A CTAG1B CTCFL CTSB CTSE CTSL CXCL8 CYSRT1 DMKN DNAJB11 DPT EDN1 EFEMP1 EFEMP2 ELP1 EP300 FAM9B FAS FKBP2 FZD4 GADD45A GET4 GLRA2 GOLGA6L9 GSK3B HSPA13 HSPA8 IGF2 IGFBP5 IMMT IQCG KLHL12 KPNA2 LBP MAPK6 MEST MTNR1A MYDGF NBL1 NCR3 NDUFA6 NDUFB11 NOMO1 NPY NR1H2 PELP1 PIN1 PLA2G2A PLK1 PLPP2 PLPPR3 POLR2J PRKAR1B PRMT2 PRNP PRPF40A PTH PTN PTPN12 RAB8A RAC1 RCC1 RCN2 REG1B RNF126 S100A4 SDC2 SEC61A1 SEC61B SERPING1 SERPINH1 SERPINI2 SETDB1 SGTA SMN1 SPP1 SRGN STX5 TAC1 TDGF1 TENT5A TFCP2 TK1 TOMM20 TP53 TP63 TTR UBL4B UBL7 UBQLN1 UBQLN2 UBQLN4 USP13 VAMP2 XRN1 ZFYVE9	7 interacting genes: ARRB2 BAG6 DLG1 DLG2 DLG4 DVL2 MAGI3
Entrez ID		7917	8322
HPRD ID		00808	05203
Ensembl ID		ENSG00000204463	ENSG00000174804
Uniprot IDs		A0A1U9X7A6 P46379	Q9ULV1
PDB IDs		1WX9 2N9P 4DWF 4EEW 4WWR 4X86 6AU8	5BPB 5BPQ 5BQC 5BQE 5CL1 5CM4 5UWG 6BD4 6NE1
Enriched GO Terms of Interacting Partners?
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