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OTUB2 and USP21
Data Source:
BioGRID
(enzymatic study)
OTUB2
USP21
Description
OTU deubiquitinase, ubiquitin aldehyde binding 2
ubiquitin specific peptidase 21
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Molecular Function
Thiol-dependent Ubiquitin-specific Protease Activity
Protein Binding
NEDD8-specific Protease Activity
Ubiquitin Binding
Transcription Coactivator Activity
Thiol-dependent Ubiquitin-specific Protease Activity
Protein Binding
Cysteine-type Peptidase Activity
NEDD8-specific Protease Activity
Metal Ion Binding
Biological Process
Protein Deubiquitination
Protein Phosphopantetheinylation
Protein K11-linked Deubiquitination
Protein K63-linked Deubiquitination
Protein K48-linked Deubiquitination
Negative Regulation Of Histone H2A K63-linked Ubiquitination
Negative Regulation Of Double-strand Break Repair
Ubiquitin-dependent Protein Catabolic Process
Histone Deubiquitination
Protein Deubiquitination
Protein Phosphopantetheinylation
Neuron Projection Development
Positive Regulation Of Transcription, DNA-templated
Pathways
Ovarian tumor domain proteases
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Ub-specific processing proteases
Drugs
Diseases
GWAS
Interacting Genes
42 interacting genes:
APP
ARRDC3
CDIP1
CPSF6
DAZAP2
FAM168A
GLI2
KRT31
KRT40
LZTS2
MAGEA11
MID1
MID2
MKRN1
PHLDA2
PJA1
PLEKHB2
PMEPA1
RBCK1
REL
RFFL
RNF126
SIAH1
SPART
TP53BP2
TRAF6
TRIM2
TRIM25
TRIM26
TRIM27
TRIM39
TRIM5
TRIM54
TRIM55
TRIM63
TRIM8
TRIP6
U2AF2
UBC
UBE2N
USP21
USP28
59 interacting genes:
ADAMTSL4
ATXN3
AURKA
BAP1
BRCA2
CBL
CBLC
CPSF6
DTX3
EFEMP2
ESPL1
EXOSC10
FOXM1
H2AC18
HOXC10
ISG15
JOSD1
KCTD9
KRT40
LRSAM1
MAPK3
MPP1
NANOG
OTUB1
OTUB2
PCGF6
RBCK1
RNF144A
RNF185
SENP3
SENP8
SLF1
STAMBP
SYNE1
TP53
TRAF6
TRIM23
TRIM5
TRIM54
TRIM63
TRIM8
TRIM9
UBC
UBE2S
UCHL1
UCHL3
USP14
USP15
USP2
USP20
USP28
USP33
USP4
USP51
USP7
USP8
WDR47
YOD1
ZNF350
Entrez ID
78990
27005
HPRD ID
07620
05291
Ensembl ID
ENSG00000089723
ENSG00000143258
Uniprot IDs
Q96DC9
Q9UK80
PDB IDs
1TFF
4FJV
5QIO
5QIP
5QIQ
5QIR
5QIS
5QIT
5QIU
5QIV
5QIW
5QIX
5QIY
5QIZ
2Y5B
3I3T
3MTN
Enriched GO Terms of Interacting Partners
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