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CA4 and XPO1
Data Source:
HPRD
(in vivo, in vitro)
CA4
XPO1
Description
carbonic anhydrase 4
exportin 1
Image
GO Annotations
Cellular Component
Rough Endoplasmic Reticulum
Endoplasmic Reticulum-Golgi Intermediate Compartment
Golgi Apparatus
Trans-Golgi Network
Plasma Membrane
Cell Surface
Membrane
Basolateral Plasma Membrane
Apical Plasma Membrane
Transport Vesicle Membrane
Secretory Granule Membrane
Anchored Component Of External Side Of Plasma Membrane
Brush Border Membrane
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Kinetochore
Nucleus
Nuclear Envelope
Annulate Lamellae
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Cajal Body
Membrane
Nuclear Membrane
Protein-containing Complex
Intracellular Membrane-bounded Organelle
Host Cell
Ribonucleoprotein Complex
Molecular Function
Carbonate Dehydratase Activity
Protein Binding
Zinc Ion Binding
Hydro-lyase Activity
RNA Binding
Nuclear Export Signal Receptor Activity
Protein Binding
Biological Process
One-carbon Metabolic Process
Bicarbonate Transport
Ribosomal Subunit Export From Nucleus
Ribosomal Large Subunit Export From Nucleus
Ribosomal Small Subunit Export From Nucleus
Protein Export From Nucleus
Nucleocytoplasmic Transport
Viral Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Ribosome Biogenesis
Regulation Of MRNA Stability
MRNA Transport
Intracellular Transport Of Virus
Pathways
Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Reversible hydration of carbon dioxide
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Rev-mediated nuclear export of HIV RNA
NEP/NS2 Interacts with the Cellular Export Machinery
Downregulation of TGF-beta receptor signaling
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Deactivation of the beta-catenin transactivating complex
HuR (ELAVL1) binds and stabilizes mRNA
RHO GTPases Activate Formins
MAPK6/MAPK4 signaling
Mitotic Prometaphase
Cyclin A/B1/B2 associated events during G2/M transition
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
EML4 and NUDC in mitotic spindle formation
Drugs
Methyclothiazide
Topiramate
Ethoxzolamide
Bendroflumethiazide
Benzthiazide
Benzthiazide
Cyclothiazide
Methazolamide
Hydroflumethiazide
Acetazolamide
Dorzolamide
Zonisamide
Trichlormethiazide
Diclofenamide
Brinzolamide
Ellagic acid
Sodium carbonate
Selinexor
Diseases
Retinitis pigmentosa (RP)
GWAS
Atrial fibrillation (
29892015
)
Eosinophil counts (
32888494
27863252
)
Erectile dysfunction (
30583798
)
Mean reticulocyte volume (
32888494
)
Neutrophil count (
32888494
)
Sum eosinophil basophil counts (
27863252
)
Systemic lupus erythematosus (
28714469
)
Urinary sodium excretion (
31409800
)
White blood cell count (
32888494
)
Interacting Genes
5 interacting genes:
PIH1D1
PRDX2
SLC4A1
SLC4A3
SLC4A4
80 interacting genes:
ABL1
ADAR
AGFG1
AHR
ANP32A
ANP32B
APC
ATF2
BECN1
BIRC5
BRCA2
CCND1
CDC25A
CDC42
CDCA4
CDKN1B
CHEK1
CHORDC1
CIITA
CRK
DDX3X
DESI1
DR1
E2F4
E2F5
EIF5A
ERF
FBXO7
FOXO4
HDAC3
HNF4A
HSPA9
HSPB1
IRF5
KIF17
LINC01554
MAPK6
NF2
NMD3
NPM1
NUCB1
NUCB2
NUP153
NUP214
NUP50
NUP62
NXF3
NXT1
ORC1
PHAX
PHB
PKIA
RAD51
RAN
RANBP2
RANBP3
RCC1
RCN2
RGS14
RIC8A
RPS6KB1
SERPINB1
SERTAD2
SIRT2
SMAD1
SMARCB1
SMURF1
SMURF2
SNUPN
SOX2
STAT1
STRADA
SUMO1
SUMO2
TERF2IP
TERT
TOP2A
TOP2B
TP53
TP73
Entrez ID
762
7514
HPRD ID
00261
03975
Ensembl ID
ENSG00000167434
ENSG00000082898
Uniprot IDs
P22748
B3KWD0
O14980
PDB IDs
1ZNC
3F7B
3F7U
3FW3
5IPZ
5JN8
5JN9
5JNA
5JNC
5KU6
1W9C
2L1L
3GB8
4BSM
4BSN
5DIS
6TVO
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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