XPO1 and ADAR

Data Source:
BioGRID (unspecified method)
HPRD (in vivo, in vitro)

		XPO1	ADAR
Description		exportin 1	adenosine deaminase RNA specific
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GO Annotations	Cellular Component	Kinetochore Nucleus Nuclear Envelope Annulate Lamellae Nucleoplasm Nucleolus Cytoplasm Cytosol Cajal Body Membrane Nuclear Membrane Protein-containing Complex Intracellular Membrane-bounded Organelle Host Cell Ribonucleoprotein Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Membrane Supraspliceosomal Complex
	Molecular Function	RNA Binding Nuclear Export Signal Receptor Activity Protein Binding	DNA Binding RNA Binding Double-stranded RNA Binding Double-stranded RNA Adenosine Deaminase Activity Protein Binding TRNA-specific Adenosine Deaminase Activity Metal Ion Binding
	Biological Process	Ribosomal Subunit Export From Nucleus Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus Protein Export From Nucleus Nucleocytoplasmic Transport Viral Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Ribosome Biogenesis Regulation Of MRNA Stability MRNA Transport Intracellular Transport Of Virus	Osteoblast Differentiation Hematopoietic Progenitor Cell Differentiation Somatic Diversification Of Immune Receptors Via Somatic Mutation Adenosine To Inosine Editing RNA Processing MRNA Processing Response To Virus Base Conversion Or Substitution Editing Erythrocyte Differentiation Pre-miRNA Processing MiRNA Loading Onto RISC Involved In Gene Silencing By MiRNA Response To Interferon-alpha Negative Regulation Of Apoptotic Process Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Positive Regulation Of Viral Genome Replication Innate Immune Response Defense Response To Virus Definitive Hemopoiesis Type I Interferon Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway Hematopoietic Stem Cell Homeostasis Cellular Response To Virus Negative Regulation Of RNA Interference
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Rev-mediated nuclear export of HIV RNA NEP/NS2 Interacts with the Cellular Export Machinery Downregulation of TGF-beta receptor signaling Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Deactivation of the beta-catenin transactivating complex HuR (ELAVL1) binds and stabilizes mRNA RHO GTPases Activate Formins MAPK6/MAPK4 signaling Mitotic Prometaphase Cyclin A/B1/B2 associated events during G2/M transition Estrogen-dependent nuclear events downstream of ESR-membrane signaling EML4 and NUDC in mitotic spindle formation	C6 deamination of adenosine Formation of editosomes by ADAR proteins Interferon alpha/beta signaling
Drugs		Selinexor
Diseases			Dyschromatosis symmetrica hereditaria
GWAS		Atrial fibrillation ( 29892015) Eosinophil counts ( 32888494 27863252) Erectile dysfunction ( 30583798) Mean reticulocyte volume ( 32888494) Neutrophil count ( 32888494) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 28714469) Urinary sodium excretion ( 31409800) White blood cell count ( 32888494)	Apolipoprotein A1 levels ( 32203549) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Lung cancer ( 28604730) Prostate cancer ( 23535732) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		80 interacting genes: ABL1 ADAR AGFG1 AHR ANP32A ANP32B APC ATF2 BECN1 BIRC5 BRCA2 CCND1 CDC25A CDC42 CDCA4 CDKN1B CHEK1 CHORDC1 CIITA CRK DDX3X DESI1 DR1 E2F4 E2F5 EIF5A ERF FBXO7 FOXO4 HDAC3 HNF4A HSPA9 HSPB1 IRF5 KIF17 LINC01554 MAPK6 NF2 NMD3 NPM1 NUCB1 NUCB2 NUP153 NUP214 NUP50 NUP62 NXF3 NXT1 ORC1 PHAX PHB PKIA RAD51 RAN RANBP2 RANBP3 RCC1 RCN2 RGS14 RIC8A RPS6KB1 SERPINB1 SERTAD2 SIRT2 SMAD1 SMARCB1 SMURF1 SMURF2 SNUPN SOX2 STAT1 STRADA SUMO1 SUMO2 TERF2IP TERT TOP2A TOP2B TP53 TP73	6 interacting genes: ERG HDLBP PTEN TGM2 UBE2I XPO1
Entrez ID		7514	103
HPRD ID		03975	07528
Ensembl ID		ENSG00000082898	ENSG00000160710
Uniprot IDs		B3KWD0 O14980	P55265
PDB IDs		1W9C 2L1L 3GB8 4BSM 4BSN 5DIS 6TVO	1QBJ 1QGP 1XMK 2ACJ 2GXB 2L54 2MDR 3F21 3F22 3F23 3IRQ 3IRR 5ZU1 5ZUO 5ZUP
Enriched GO Terms of Interacting Partners?
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