CA4 and SLC4A3

Data Source:
HPRD (in vivo, in vitro)

		CA4	SLC4A3
Description		carbonic anhydrase 4	solute carrier family 4 member 3
Image			No pdb structure
GO Annotations	Cellular Component	Rough Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Trans-Golgi Network Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Transport Vesicle Membrane Secretory Granule Membrane Anchored Component Of External Side Of Plasma Membrane Brush Border Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	Carbonate Dehydratase Activity Protein Binding Zinc Ion Binding Hydro-lyase Activity	Inorganic Anion Exchanger Activity Protein Binding Bicarbonate Transmembrane Transporter Activity Anion:anion Antiporter Activity Transmembrane Transporter Activity
	Biological Process	One-carbon Metabolic Process Bicarbonate Transport	Inorganic Anion Transport Bicarbonate Transport Ion Homeostasis Regulation Of Intracellular PH Transmembrane Transport Cardiac Conduction Cardiac Muscle Cell Action Potential Anion Transmembrane Transport Transport Across Blood-brain Barrier
Pathways		Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide Reversible hydration of carbon dioxide	Bicarbonate transporters
Drugs		Methyclothiazide Topiramate Ethoxzolamide Bendroflumethiazide Benzthiazide Benzthiazide Cyclothiazide Methazolamide Hydroflumethiazide Acetazolamide Dorzolamide Zonisamide Trichlormethiazide Diclofenamide Brinzolamide Ellagic acid Sodium carbonate
Diseases		Retinitis pigmentosa (RP)
GWAS			Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Immune response to measles-mumps-rubella vaccine ( 24811271) QT interval ( 29874175)
Interacting Genes		5 interacting genes: PIH1D1 PRDX2 SLC4A1 SLC4A3 SLC4A4	5 interacting genes: ANK1 CA2 CA4 DRD2 PRKCE
Entrez ID		762	6508
HPRD ID		00261	00109
Ensembl ID		ENSG00000167434	ENSG00000114923
Uniprot IDs		P22748	P48751
PDB IDs		1ZNC 3F7B 3F7U 3FW3 5IPZ 5JN8 5JN9 5JNA 5JNC 5KU6
Enriched GO Terms of Interacting Partners?
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