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YWHAG and CBL
Data Source:
HPRD
(in vivo)
YWHAG
CBL
Description
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
Cbl proto-oncogene
Image
GO Annotations
Cellular Component
Mitochondrion
Cytosol
Focal Adhesion
Membrane
Extracellular Exosome
Presynapse
Golgi Apparatus
Cytosol
Plasma Membrane
Focal Adhesion
Cilium
Flotillin Complex
Growth Cone
Membrane Raft
Perinuclear Region Of Cytoplasm
Molecular Function
RNA Binding
Protein Kinase C Binding
Insulin-like Growth Factor Receptor Binding
Protein Binding
Protein Kinase C Inhibitor Activity
Protein Domain Specific Binding
Receptor Tyrosine Kinase Binding
Identical Protein Binding
Phosphotyrosine Residue Binding
Ubiquitin-protein Transferase Activity
Epidermal Growth Factor Receptor Binding
Calcium Ion Binding
Protein Binding
SH3 Domain Binding
Receptor Tyrosine Kinase Binding
Phosphatidylinositol 3-kinase Regulatory Subunit Binding
Cadherin Binding
Ephrin Receptor Binding
Ubiquitin Protein Ligase Activity
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Protein Kinase Activity
Protein Targeting
Regulation Of Signal Transduction
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Cellular Response To Insulin Stimulus
Regulation Of Neuron Differentiation
Regulation Of Synaptic Plasticity
Membrane Organization
Negative Regulation Of Protein Serine/threonine Kinase Activity
Ciliary Basal Body-plasma Membrane Docking
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Cellular Response To DNA Damage Stimulus
Signal Transduction
Cell Surface Receptor Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity
Transforming Growth Factor Beta Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Male Gonad Development
Response To Gamma Radiation
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Response To Activity
Protein Ubiquitination
Cytokine-mediated Signaling Pathway
Regulation Of Rap Protein Signal Transduction
Response To Testosterone
Entry Of Bacterium Into Host Cell
Cellular Response To Platelet-derived Growth Factor Stimulus
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Response To Starvation
Negative Regulation Of Apoptotic Process
Mast Cell Degranulation
Response To Ethanol
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Response To Antibiotic
Positive Regulation Of Receptor-mediated Endocytosis
Membrane Organization
Interleukin-6-mediated Signaling Pathway
Neuron Death
Cellular Response To Epidermal Growth Factor Stimulus
Cellular Response To Oxygen-glucose Deprivation
Negative Regulation Of Neuron Death
Cellular Response To Nerve Growth Factor Stimulus
Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway
Pathways
Activation of BAD and translocation to mitochondria
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
RHO GTPases activate PKNs
TP53 Regulates Metabolic Genes
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
AURKA Activation by TPX2
Regulation of localization of FOXO transcription factors
Interleukin-6 signaling
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
Spry regulation of FGF signaling
Regulation of KIT signaling
EGFR downregulation
TGF-beta receptor signaling activates SMADs
Constitutive Signaling by EGFRvIII
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
Negative regulation of MET activity
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
InlB-mediated entry of Listeria monocytogenes into host cell
InlB-mediated entry of Listeria monocytogenes into host cell
Regulation of signaling by CBL
Regulation of signaling by CBL
Negative regulation of FLT3
FLT3 signaling by CBL mutants
Drugs
Diseases
Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS
Multiple sclerosis (
21654844
)
Schizophrenia (
30285260
)
High light scatter reticulocyte count (
32888494
27863252
)
High light scatter reticulocyte percentage of red cells (
32888494
27863252
)
Mean corpuscular volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Platelet count (
22139419
29403010
32888494
27863252
)
Plateletcrit (
32888494
27863252
)
Reticulocyte count (
32888494
27863252
)
Reticulocyte fraction of red cells (
32888494
27863252
)
Interacting Genes
290 interacting genes:
ABL1
ABLIM1
ACIN1
AFDN
AKAP13
AKT1S1
ALB
ANKHD1-EIF4EBP3
ANKS1A
APP
ARAF
ARHGEF2
ARHGEF6
ARHGEF7
ATP5F1A
ATP5F1B
ATP6V0B
BAD
BAIAP2
BAIAP2L1
BCLAF1
BCR
BRAF
C1QBP
CAD
CAMKK1
CASP3
CBL
CCNY
CCS
CCT2
CDC5L
CDK11B
CDK16
CDK17
CDKN1B
CENPJ
CEP170
CEP250
CEP95
CFAP20
CFL1
CGN
CGNL1
CHAF1A
CHEK1
CKAP2
CLASP1
CLINT1
CLK1
CLK2
CLK3
CLTC
COPS5
CPSF3
CRTC1
CRTC2
CRTC3
CSE1L
CTNND1
CTPS1
CYFIP2
DCAF7
DCP1A
DDX17
DDX27
DDX39B
DENND4A
DFFA
DHX15
DISC1
DOCK7
DYNC1H1
DYRK1A
EDC3
EEF1A1
EEF1G
EML3
EPB41L2
EPB41L3
EPN2
ERC1
EWSR1
EXO1
FAM13B
FARP2
FGD6
FLNA
FOXO1
FOXO3
GBF1
GIT1
GIT2
GSK3A
GTPBP4
H3C1
HDAC4
HDAC7
HECTD1
HGF
HIVEP2
HNRNPAB
HNRNPH1
HNRNPM
HOXC10
HSPA1A
HSPA8
HSPA9
HSPB6
HSPD1
IGF1R
IL7R
ING1
INPP5E
IRS1
IRS2
IRS4
ITPRID2
JAKMIP1
KANK1
KAT5
KCNK15
KCNK3
KCNK9
KIAA0408
KIAA0930
KIF1B
KIF1C
KIF23
KIF5B
KIF5C
KLC2
KLC3
KRT18
LARP1
LATS2
LBR
LIMA1
LMO7
LRCH3
LSR
LTB4R
LUC7L2
LUC7L3
MAGOHB
MAP3K2
MAP3K20
MAP3K3
MAPKAP1
MARK3
MCM5
MDM4
MFAP1
MICALL1
MIEF1
MPHOSPH9
MPRIP
MSL2
MYCBP2
MYH10
N4BP3
NCKAP1
NCKIPSD
NDE1
NDEL1
NEDD4L
NEFL
NHSL2
NOLC1
NUFIP2
NUMBL
OSBPL3
P4HB
PABPC1
PAK1
PAK4
PARD3
PARD3B
PFKFB2
PGAM5
PHLDB2
PI4KB
PIK3C3
PIK3R1
PKP2
PLA2G12A
PLEKHA5
PNN
POT1
PPFIA1
PPFIBP1
PPIG
PPP1R12A
PPP6R3
PRKCA
PRKCB
PRKCD
PRKCG
PRKCQ
PRKDC
PRLR
PRMT1
PRMT5
PRPF38B
PRPF40A
PRPF4B
PTPN14
PTPN3
PUF60
RAB11FIP2
RAB11FIP5
RABEP1
RACGAP1
RAF1
RAI14
RALGPS2
RAPGEF6
RASAL2
RASSF8
RGS12
RIPOR2
RMDN3
RNPS1
RPS2
RRM1
SAMD4A
SAMD4B
SF3B3
SFN
SH3BP4
SH3BP5L
SHKBP1
SHPRH
SHROOM2
SIMC1
SLC25A3
SMARCD1
SNRNP200
SON
SPOP
SPTBN1
SRC
SRGAP2
SRPK1
SRRM1
SRRM2
SRSF10
SRSF3
STK11
SVIL
SYNPO
SYNPO2
TAB1
TAF15
TBC1D1
TBC1D4
TERF1
TFE3
THRAP3
TIAM1
TINF2
TJP2
TMEM102
TNFAIP3
TP53
TP53BP2
TRA2A
TRA2B
TSC1
TSC2
TUBA4A
TUBB
TUBB4A
UBC
UBE3A
UCP2
UCP3
USP37
USP8
WEE1
WNK1
WWTR1
YAP1
YWHAB
YWHAE
YWHAH
YWHAQ
YWHAZ
ZBTB21
ZFP36
128 interacting genes:
ABL1
APPL1
ASAP1
AXL
BCR
BLK
BLNK
BTK
CAPN1
CBLIF
CD19
CD2AP
CD38
CD40
CD5
CDKL2
CRK
CRKL
CSF1R
CTNNB1
CUBN
EGFR
EIF5B
EPHA2
EPHB6
EPOR
EPS8
F2RL1
FGR
FLOT1
FLT3
FNBP1
FRS2
FYB1
FYN
GRAP2
GRB2
HCK
IGF1R
INPPL1
INSR
ITCH
ITK
ITSN2
JAK2
KDR
KHDRBS1
KIT
KRT18
LAT
LAT2
LCK
LCP2
LRIG1
LTK
LYN
MAPK8
MET
MYH9
MYO1C
MZF1
NCK1
NECTIN1
NOTCH1
OSTF1
PDGFRA
PDGFRB
PIK3R1
PIK3R2
PLCG1
PRKCA
PRKCQ
PTK2B
PTPN11
PTPN22
PTPN6
RET
SCN5A
SERPINA5
SH2B2
SH3KBP1
SHC1
SLA
SLA2
SMAD7
SORBS1
SORBS2
SP7
SPRY2
SRC
STAP2
STAT3
STAT5A
STAT5B
SYK
TCN1
TCN2
TGM2
TNFRSF11A
TNS4
TRAF4
TRAF6
TRIM8
TYK2
UBASH3B
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2G1
UBE2G2
UBE2L3
UBE2M
UBE2N
UBE2U
UBE2W
USP21
VAV1
VAV2
YES1
YWHAB
YWHAG
YWHAQ
YWHAZ
ZAP70
Entrez ID
7532
867
HPRD ID
05639
01320
Ensembl ID
ENSG00000170027
ENSG00000110395
Uniprot IDs
P61981
P22681
PDB IDs
2B05
3UZD
4E2E
4J6S
4O46
5D3E
6A5S
6BYJ
6BYL
6BZD
6FEL
6GKF
6GKG
6S9K
6SAD
1B47
1FBV
1YVH
2CBL
2JUJ
2K4D
2OO9
2Y1M
2Y1N
3BUM
3BUN
3BUO
3BUW
3BUX
3OB1
3OB2
3PLF
4A49
4A4B
4A4C
4GPL
5HKW
5HKX
5HKY
5HKZ
5HL0
5J3X
5O76
6O02
6O03
Enriched GO Terms of Interacting Partners
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