YWHAG and PTPN3

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, proximity labelling technology, affinity chromatography technology, two hybrid)

		YWHAG	PTPN3
Description		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma	protein tyrosine phosphatase non-receptor type 3
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GO Annotations	Cellular Component	Mitochondrion Cytosol Focal Adhesion Membrane Extracellular Exosome Presynapse	Cytoplasm Cytoskeleton Plasma Membrane Cytoplasmic Side Of Plasma Membrane
	Molecular Function	RNA Binding Protein Kinase C Binding Insulin-like Growth Factor Receptor Binding Protein Binding Protein Kinase C Inhibitor Activity Protein Domain Specific Binding Receptor Tyrosine Kinase Binding Identical Protein Binding	Phosphotyrosine Residue Binding Protein Tyrosine Phosphatase Activity Protein Binding Cytoskeletal Protein Binding Sodium Channel Regulator Activity ATPase Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Protein Kinase Activity Protein Targeting Regulation Of Signal Transduction Regulation Of G2/M Transition Of Mitotic Cell Cycle Cellular Response To Insulin Stimulus Regulation Of Neuron Differentiation Regulation Of Synaptic Plasticity Membrane Organization Negative Regulation Of Protein Serine/threonine Kinase Activity Ciliary Basal Body-plasma Membrane Docking Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Membrane Protein Ectodomain Proteolysis Liver Regeneration Regulation Of Membrane Depolarization During Action Potential Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex AURKA Activation by TPX2 Regulation of localization of FOXO transcription factors	EGFR downregulation Negative regulation of MAPK pathway
Drugs
Diseases
GWAS		Multiple sclerosis ( 21654844) Schizophrenia ( 30285260)	Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31015462) HIV-associated neurocognitive disorder ( 28447399) HIV-associated neurocognitive disorder (asymptomatic neurocogntive impairment) ( 28447399) HIV-associated neurocognitive disorder (mild neurocognitive disorder or asymptomatic neurocognitive impairment) ( 28447399) Iris color (a* coordinate) ( 30895295) Iris color (b* coordinate) ( 30895295) Red blood cell density in sickle cell anemia ( 28552477) Serum albumin level ( 29403010) Staphylococcus aureus nasal carriage (persistent) ( 26569114) Triglyceride levels ( 32203549)
Interacting Genes		290 interacting genes: ABL1 ABLIM1 ACIN1 AFDN AKAP13 AKT1S1 ALB ANKHD1-EIF4EBP3 ANKS1A APP ARAF ARHGEF2 ARHGEF6 ARHGEF7 ATP5F1A ATP5F1B ATP6V0B BAD BAIAP2 BAIAP2L1 BCLAF1 BCR BRAF C1QBP CAD CAMKK1 CASP3 CBL CCNY CCS CCT2 CDC5L CDK11B CDK16 CDK17 CDKN1B CENPJ CEP170 CEP250 CEP95 CFAP20 CFL1 CGN CGNL1 CHAF1A CHEK1 CKAP2 CLASP1 CLINT1 CLK1 CLK2 CLK3 CLTC COPS5 CPSF3 CRTC1 CRTC2 CRTC3 CSE1L CTNND1 CTPS1 CYFIP2 DCAF7 DCP1A DDX17 DDX27 DDX39B DENND4A DFFA DHX15 DISC1 DOCK7 DYNC1H1 DYRK1A EDC3 EEF1A1 EEF1G EML3 EPB41L2 EPB41L3 EPN2 ERC1 EWSR1 EXO1 FAM13B FARP2 FGD6 FLNA FOXO1 FOXO3 GBF1 GIT1 GIT2 GSK3A GTPBP4 H3C1 HDAC4 HDAC7 HECTD1 HGF HIVEP2 HNRNPAB HNRNPH1 HNRNPM HOXC10 HSPA1A HSPA8 HSPA9 HSPB6 HSPD1 IGF1R IL7R ING1 INPP5E IRS1 IRS2 IRS4 ITPRID2 JAKMIP1 KANK1 KAT5 KCNK15 KCNK3 KCNK9 KIAA0408 KIAA0930 KIF1B KIF1C KIF23 KIF5B KIF5C KLC2 KLC3 KRT18 LARP1 LATS2 LBR LIMA1 LMO7 LRCH3 LSR LTB4R LUC7L2 LUC7L3 MAGOHB MAP3K2 MAP3K20 MAP3K3 MAPKAP1 MARK3 MCM5 MDM4 MFAP1 MICALL1 MIEF1 MPHOSPH9 MPRIP MSL2 MYCBP2 MYH10 N4BP3 NCKAP1 NCKIPSD NDE1 NDEL1 NEDD4L NEFL NHSL2 NOLC1 NUFIP2 NUMBL OSBPL3 P4HB PABPC1 PAK1 PAK4 PARD3 PARD3B PFKFB2 PGAM5 PHLDB2 PI4KB PIK3C3 PIK3R1 PKP2 PLA2G12A PLEKHA5 PNN POT1 PPFIA1 PPFIBP1 PPIG PPP1R12A PPP6R3 PRKCA PRKCB PRKCD PRKCG PRKCQ PRKDC PRLR PRMT1 PRMT5 PRPF38B PRPF40A PRPF4B PTPN14 PTPN3 PUF60 RAB11FIP2 RAB11FIP5 RABEP1 RACGAP1 RAF1 RAI14 RALGPS2 RAPGEF6 RASAL2 RASSF8 RGS12 RIPOR2 RMDN3 RNPS1 RPS2 RRM1 SAMD4A SAMD4B SF3B3 SFN SH3BP4 SH3BP5L SHKBP1 SHPRH SHROOM2 SIMC1 SLC25A3 SMARCD1 SNRNP200 SON SPOP SPTBN1 SRC SRGAP2 SRPK1 SRRM1 SRRM2 SRSF10 SRSF3 STK11 SVIL SYNPO SYNPO2 TAB1 TAF15 TBC1D1 TBC1D4 TERF1 TFE3 THRAP3 TIAM1 TINF2 TJP2 TMEM102 TNFAIP3 TP53 TP53BP2 TRA2A TRA2B TSC1 TSC2 TUBA4A TUBB TUBB4A UBC UBE3A UCP2 UCP3 USP37 USP8 WEE1 WNK1 WWTR1 YAP1 YWHAB YWHAE YWHAH YWHAQ YWHAZ ZBTB21 ZFP36	26 interacting genes: ADAM17 AKR1C1 AKT1 CD247 DIP2A GHR HSPB1 LMO1 MAPK12 MLH1 MTMR9 NXT2 PLEKHF2 RNF111 RPS6KA1 TENT5D TFAP4 TRIM41 VCP VWA2 WDR6 YWHAB YWHAG YWHAQ ZAP70 ZCCHC10
Entrez ID		7532	5774
HPRD ID		05639	06767
Ensembl ID		ENSG00000170027	ENSG00000070159
Uniprot IDs		P61981	B7Z3V3 B7Z9V1 B7ZA03 P26045 Q8N4S3
PDB IDs		2B05 3UZD 4E2E 4J6S 4O46 5D3E 6A5S 6BYJ 6BYL 6BZD 6FEL 6GKF 6GKG 6S9K 6SAD	2B49 4QUM 4QUN 4RH5 4RH9 4RHG 4RI4 4RI5 4S0G 6HKS
Enriched GO Terms of Interacting Partners?
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