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YWHAG and LATS2
Data Source:
BioGRID
(fluorescent resonance energy transfer, enzymatic study)
YWHAG
LATS2
Description
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
large tumor suppressor kinase 2
Image
GO Annotations
Cellular Component
Mitochondrion
Cytosol
Focal Adhesion
Membrane
Extracellular Exosome
Presynapse
Spindle Pole
Nucleus
Cytosol
Centriolar Satellite
Molecular Function
RNA Binding
Protein Kinase C Binding
Insulin-like Growth Factor Receptor Binding
Protein Binding
Protein Kinase C Inhibitor Activity
Protein Domain Specific Binding
Receptor Tyrosine Kinase Binding
Identical Protein Binding
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Metal Ion Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Protein Kinase Activity
Protein Targeting
Regulation Of Signal Transduction
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Cellular Response To Insulin Stimulus
Regulation Of Neuron Differentiation
Regulation Of Synaptic Plasticity
Membrane Organization
Negative Regulation Of Protein Serine/threonine Kinase Activity
Ciliary Basal Body-plasma Membrane Docking
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
G1/S Transition Of Mitotic Cell Cycle
Protein Phosphorylation
Hormone-mediated Signaling Pathway
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Peptidyl-serine Phosphorylation
Hippo Signaling
Intracellular Signal Transduction
Positive Regulation Of Apoptotic Process
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Regulation Of Organ Growth
Cell Division
Negative Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Protein Localization To Nucleus
Pathways
Activation of BAD and translocation to mitochondria
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
RHO GTPases activate PKNs
TP53 Regulates Metabolic Genes
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
AURKA Activation by TPX2
Regulation of localization of FOXO transcription factors
Signaling by Hippo
Drugs
Diseases
GWAS
Multiple sclerosis (
21654844
)
Schizophrenia (
30285260
)
3-month functional outcome in ischaemic stroke (modified Rankin score) (
30796134
)
Refractive error (
32231278
)
Interacting Genes
290 interacting genes:
ABL1
ABLIM1
ACIN1
AFDN
AKAP13
AKT1S1
ALB
ANKHD1-EIF4EBP3
ANKS1A
APP
ARAF
ARHGEF2
ARHGEF6
ARHGEF7
ATP5F1A
ATP5F1B
ATP6V0B
BAD
BAIAP2
BAIAP2L1
BCLAF1
BCR
BRAF
C1QBP
CAD
CAMKK1
CASP3
CBL
CCNY
CCS
CCT2
CDC5L
CDK11B
CDK16
CDK17
CDKN1B
CENPJ
CEP170
CEP250
CEP95
CFAP20
CFL1
CGN
CGNL1
CHAF1A
CHEK1
CKAP2
CLASP1
CLINT1
CLK1
CLK2
CLK3
CLTC
COPS5
CPSF3
CRTC1
CRTC2
CRTC3
CSE1L
CTNND1
CTPS1
CYFIP2
DCAF7
DCP1A
DDX17
DDX27
DDX39B
DENND4A
DFFA
DHX15
DISC1
DOCK7
DYNC1H1
DYRK1A
EDC3
EEF1A1
EEF1G
EML3
EPB41L2
EPB41L3
EPN2
ERC1
EWSR1
EXO1
FAM13B
FARP2
FGD6
FLNA
FOXO1
FOXO3
GBF1
GIT1
GIT2
GSK3A
GTPBP4
H3C1
HDAC4
HDAC7
HECTD1
HGF
HIVEP2
HNRNPAB
HNRNPH1
HNRNPM
HOXC10
HSPA1A
HSPA8
HSPA9
HSPB6
HSPD1
IGF1R
IL7R
ING1
INPP5E
IRS1
IRS2
IRS4
ITPRID2
JAKMIP1
KANK1
KAT5
KCNK15
KCNK3
KCNK9
KIAA0408
KIAA0930
KIF1B
KIF1C
KIF23
KIF5B
KIF5C
KLC2
KLC3
KRT18
LARP1
LATS2
LBR
LIMA1
LMO7
LRCH3
LSR
LTB4R
LUC7L2
LUC7L3
MAGOHB
MAP3K2
MAP3K20
MAP3K3
MAPKAP1
MARK3
MCM5
MDM4
MFAP1
MICALL1
MIEF1
MPHOSPH9
MPRIP
MSL2
MYCBP2
MYH10
N4BP3
NCKAP1
NCKIPSD
NDE1
NDEL1
NEDD4L
NEFL
NHSL2
NOLC1
NUFIP2
NUMBL
OSBPL3
P4HB
PABPC1
PAK1
PAK4
PARD3
PARD3B
PFKFB2
PGAM5
PHLDB2
PI4KB
PIK3C3
PIK3R1
PKP2
PLA2G12A
PLEKHA5
PNN
POT1
PPFIA1
PPFIBP1
PPIG
PPP1R12A
PPP6R3
PRKCA
PRKCB
PRKCD
PRKCG
PRKCQ
PRKDC
PRLR
PRMT1
PRMT5
PRPF38B
PRPF40A
PRPF4B
PTPN14
PTPN3
PUF60
RAB11FIP2
RAB11FIP5
RABEP1
RACGAP1
RAF1
RAI14
RALGPS2
RAPGEF6
RASAL2
RASSF8
RGS12
RIPOR2
RMDN3
RNPS1
RPS2
RRM1
SAMD4A
SAMD4B
SF3B3
SFN
SH3BP4
SH3BP5L
SHKBP1
SHPRH
SHROOM2
SIMC1
SLC25A3
SMARCD1
SNRNP200
SON
SPOP
SPTBN1
SRC
SRGAP2
SRPK1
SRRM1
SRRM2
SRSF10
SRSF3
STK11
SVIL
SYNPO
SYNPO2
TAB1
TAF15
TBC1D1
TBC1D4
TERF1
TFE3
THRAP3
TIAM1
TINF2
TJP2
TMEM102
TNFAIP3
TP53
TP53BP2
TRA2A
TRA2B
TSC1
TSC2
TUBA4A
TUBB
TUBB4A
UBC
UBE3A
UCP2
UCP3
USP37
USP8
WEE1
WNK1
WWTR1
YAP1
YWHAB
YWHAE
YWHAH
YWHAQ
YWHAZ
ZBTB21
ZFP36
67 interacting genes:
ABL1
AJUBA
AKT1
ARAF
ARNT
AURKA
AURKB
BECN1
BRAF
CBLC
CCND2
CCNE1
CD44
CDK2
CDK4
CDK6
CDKN1A
CDKN2A
CDKN2B
CDKN2C
CHEK1
CHEK2
CTNNB1
DYRK1A
EPHA2
ERBB2
EZH2
FGFR4
FHL3
FZR1
GLIS1
GLIS2
GRAP2
GRM1
HGF
HIF1A
KAT2A
KDELR2
KIF23
MAP2K3
MAP2K5
MAPK14
MDM4
MET
MOB3A
MOB3B
MOB3C
MOB4
MYC
NF2
NFIC
PDGFRA
RAF1
RASSF1
RELA
SMAD2
SNAI1
STK11
STK3
SUZ12
TAZ
TEAD2
TP53
TSC1
WWTR1
YWHAG
YWHAZ
Entrez ID
7532
26524
HPRD ID
05639
07277
Ensembl ID
ENSG00000170027
ENSG00000150457
Uniprot IDs
P61981
A0A024RDM3
Q9NRM7
PDB IDs
2B05
3UZD
4E2E
4J6S
4O46
5D3E
6A5S
6BYJ
6BYL
6BZD
6FEL
6GKF
6GKG
6S9K
6SAD
4ZRI
Enriched GO Terms of Interacting Partners
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