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XRCC3 and TFF1
Data Source:
BioGRID
(two hybrid)
XRCC3
TFF1
Description
X-ray repair cross complementing 3
trefoil factor 1
Image
No pdb structure
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Replication Fork
Cytoplasm
Mitochondrion
Cytosol
Rad51C-XRCC3 Complex
Perinuclear Region Of Cytoplasm
Extracellular Region
Extracellular Space
Molecular Function
Four-way Junction DNA Binding
Protein Binding
ATP Binding
DNA-dependent ATPase Activity
Crossover Junction Endodeoxyribonuclease Activity
Protein Binding
Growth Factor Activity
Biological Process
Telomere Maintenance Via Recombination
Double-strand Break Repair Via Homologous Recombination
DNA Repair
DNA Recombination
Cellular Response To DNA Damage Stimulus
Response To Organic Substance
Regulation Of Centrosome Duplication
Interstrand Cross-link Repair
Double-strand Break Repair Via Synthesis-dependent Strand Annealing
Resolution Of Mitotic Recombination Intermediates
Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
T-circle Formation
Telomeric Loop Disassembly
Telomere Maintenance Via Telomere Trimming
Carbohydrate Metabolic Process
Signal Transduction
Negative Regulation Of Cell Population Proliferation
Response To Iron Ion
Cell Differentiation
Maintenance Of Gastrointestinal Epithelium
Response To Immobilization Stress
Response To Peptide Hormone
Pathways
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Estrogen-dependent gene expression
Drugs
Raloxifene
Afimoxifene
Diseases
GWAS
Autism spectrum disorder or schizophrenia (
28540026
)
Bipolar disorder (
31043756
)
Body mass index (
26426971
29273807
)
Schizophrenia (
25056061
29483656
)
Blood protein levels (
30072576
29875488
)
Pancreatic cancer (
22158540
)
Interacting Genes
22 interacting genes:
BAP1
BCAS3
CXCL1
FANCG
GREB1
ITIH5
LRATD2
MRC2
OSGIN1
PALB2
PSMC3IP
RAD51
RAD51C
RAD51D
RNF20
SCGB3A1
SERPINB5
SNAI1
SWSAP1
TFF1
ZNHIT3
ZSWIM7
20 interacting genes:
AKT1
APC
ATM
BTN3A1
BTNL8
CD300LD
ESR2
FCRL4
FGFR2
GKN2
MUC6
RAD51
SGTB
SIGLEC8
TSG101
UBQLN1
UBQLN4
VSNL1
XRCC3
ZNF250
Entrez ID
7517
7031
HPRD ID
07201
00219
Ensembl ID
ENSG00000126215
ENSG00000160182
Uniprot IDs
O43542
Q53XC8
P04155
PDB IDs
1HI7
1PS2
6V1D
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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