XRCC3 and LRATD2

Data Source:
BioGRID (two hybrid)

		XRCC3	LRATD2
Description		X-ray repair cross complementing 3	LRAT domain containing 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Cytoplasm Mitochondrion Cytosol Rad51C-XRCC3 Complex Perinuclear Region Of Cytoplasm	Cytoplasm Plasma Membrane
	Molecular Function	Four-way Junction DNA Binding Protein Binding ATP Binding DNA-dependent ATPase Activity Crossover Junction Endodeoxyribonuclease Activity	Protein Binding
	Biological Process	Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination Cellular Response To DNA Damage Stimulus Response To Organic Substance Regulation Of Centrosome Duplication Interstrand Cross-link Repair Double-strand Break Repair Via Synthesis-dependent Strand Annealing Resolution Of Mitotic Recombination Intermediates Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint T-circle Formation Telomeric Loop Disassembly Telomere Maintenance Via Telomere Trimming
Pathways		HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Body mass index ( 26426971 29273807) Schizophrenia ( 25056061 29483656)
Interacting Genes		22 interacting genes: BAP1 BCAS3 CXCL1 FANCG GREB1 ITIH5 LRATD2 MRC2 OSGIN1 PALB2 PSMC3IP RAD51 RAD51C RAD51D RNF20 SCGB3A1 SERPINB5 SNAI1 SWSAP1 TFF1 ZNHIT3 ZSWIM7	14 interacting genes: ADRB2 AP1M1 BAG4 CTNNA1 DDIT4L ESR2 FGFR4 NOTCH2 PALB2 PTPN1 SMAD4 TAX1BP1 UROD XRCC3
Entrez ID		7517	157638
HPRD ID		07201	11403
Ensembl ID		ENSG00000126215	ENSG00000168672
Uniprot IDs		O43542 Q53XC8	Q96KN1
PDB IDs
Enriched GO Terms of Interacting Partners?
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