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UBE2V2 and RFFL
Data Source:
BioGRID
(pull down)
UBE2V2
RFFL
Description
ubiquitin conjugating enzyme E2 V2
ring finger and FYVE like domain containing E3 ubiquitin protein ligase
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
UBC13-MMS2 Complex
Extracellular Exosome
Golgi Membrane
Nucleoplasm
Cytoplasm
Lysosome
Cytosol
Plasma Membrane
Endosome Membrane
Membrane
Recycling Endosome Membrane
Molecular Function
Protein Binding
Protease Binding
P53 Binding
Protein Binding
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Biological Process
Protein Polyubiquitination
DNA Double-strand Break Processing
Regulation Of DNA Repair
Postreplication Repair
Double-strand Break Repair Via Nonhomologous End Joining
Positive Regulation Of Neuron Projection Development
Protein Ubiquitination
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Error-free Postreplication DNA Repair
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of DNA Repair
Positive Regulation Of Synapse Assembly
Protein K63-linked Ubiquitination
Ubiquitin-dependent Protein Catabolic Process
Apoptotic Process
Regulation Of Fibroblast Migration
Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Regulation Of TOR Signaling
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein K48-linked Ubiquitination
Negative Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Pathways
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Formation of Incision Complex in GG-NER
G2/M DNA damage checkpoint
E3 ubiquitin ligases ubiquitinate target proteins
Antigen processing: Ubiquitination & Proteasome degradation
Regulation of TP53 Degradation
Drugs
Diseases
GWAS
Height (
31562340
)
Acute post-radiotherapy pain in breast cancer (
31196165
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Night sleep phenotypes (
27126917
)
QT interval (
19305408
)
Interacting Genes
33 interacting genes:
BCL10
DZIP3
EGFR
HLTF
IGSF21
LNX1
LRIF1
MALT1
MKRN3
MOB4
MUL1
OTUB1
RC3H1
RC3H2
RFFL
RNF144A
RNF2
RNF8
SHPRH
SIAH1
SIAH2
STUB1
SUV39H2
TP53
TRAF2
TRIM21
TRIM5
TRIM54
TRIM63
UBC
UBE2N
XIAP
ZNRF1
21 interacting genes:
ATXN3
ATXN3L
EHD1
ESPL1
MICALL1
OPTN
OTUB1
OTUB2
RAB11FIP1
SFN
STAM
UBE2D1
UBE2D2
UBE2D3
UBE2G2
UBE2N
UBE2V2
UCHL5
USP28
USP5
USP7
Entrez ID
7336
117584
HPRD ID
04300
11489
Ensembl ID
ENSG00000169139
ENSG00000092871
Uniprot IDs
A0M8W4
Q15819
Q8WZ73
PDB IDs
1J74
1J7D
1ZGU
3VON
4NR3
4NRG
4NRI
4ONL
4ONM
4ONN
4ORH
5AIT
1Y02
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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