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RFFL and ATXN3L
Data Source:
BioGRID
(enzymatic study)
RFFL
ATXN3L
Description
ring finger and FYVE like domain containing E3 ubiquitin protein ligase
ataxin 3 like
Image
GO Annotations
Cellular Component
Golgi Membrane
Nucleoplasm
Cytoplasm
Lysosome
Cytosol
Plasma Membrane
Endosome Membrane
Membrane
Recycling Endosome Membrane
Nucleus
Cytosol
Molecular Function
Protease Binding
P53 Binding
Protein Binding
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Thiol-dependent Ubiquitin-specific Protease Activity
Cysteine-type Peptidase Activity
Biological Process
Ubiquitin-dependent Protein Catabolic Process
Apoptotic Process
Regulation Of Fibroblast Migration
Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Regulation Of TOR Signaling
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein K48-linked Ubiquitination
Negative Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Protein Deubiquitination
Protein Phosphopantetheinylation
Pathways
Regulation of TP53 Degradation
Josephin domain DUBs
Drugs
Diseases
GWAS
Acute post-radiotherapy pain in breast cancer (
31196165
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Night sleep phenotypes (
27126917
)
QT interval (
19305408
)
Bipolar disorder (
31043756
)
Interacting Genes
21 interacting genes:
ATXN3
ATXN3L
EHD1
ESPL1
MICALL1
OPTN
OTUB1
OTUB2
RAB11FIP1
SFN
STAM
UBE2D1
UBE2D2
UBE2D3
UBE2G2
UBE2N
UBE2V2
UCHL5
USP28
USP5
USP7
8 interacting genes:
KLF5
PJA1
RFFL
TRIM54
TRIM55
TRIM63
UBC
USP28
Entrez ID
117584
92552
HPRD ID
11489
19697
Ensembl ID
ENSG00000092871
ENSG00000123594
Uniprot IDs
Q8WZ73
B4DYC7
Q9H3M9
PDB IDs
1Y02
3O65
Enriched GO Terms of Interacting Partners
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