TSG101 and PRDM16

Data Source:
BioGRID (two hybrid)

		TSG101	PRDM16
Description		tumor susceptibility 101	PR/SET domain 16
Image
GO Annotations	Cellular Component	ESCRT I Complex Nucleolus Cytoplasm Endosome Early Endosome Late Endosome Multivesicular Body Microtubule Organizing Center Cytosol Plasma Membrane Endosome Membrane Early Endosome Membrane Late Endosome Membrane Host Cell Extracellular Exosome Flemming Body	Nucleus Nucleoplasm Cytosol Aggresome Transcription Repressor Complex
	Molecular Function	DNA Binding Transcription Corepressor Activity Protein Binding Nuclear Receptor Coactivator Activity Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Ubiquitin Binding Protein-containing Complex Binding Virion Binding Calcium-dependent Protein Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Activating Transcription Factor Binding Sequence-specific DNA Binding Metal Ion Binding Histone Methyltransferase Activity (H3-K9 Specific)
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Protein Monoubiquitination Extracellular Transport Cell Cycle Arrest Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Cell Population Proliferation Endosome To Lysosome Transport Protein Transport Endosomal Transport Macroautophagy Viral Life Cycle Keratinocyte Differentiation Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of MAP Kinase Activity Positive Regulation Of Transcription, DNA-templated Viral Budding Cell Division Intracellular Transport Of Virus Autophagosome Maturation Regulation Of Viral Release From Host Cell Positive Regulation Of Viral Release From Host Cell Positive Regulation Of Exosomal Secretion Regulation Of Extracellular Exosome Assembly Positive Regulation Of Viral Budding Via Host ESCRT Complex Exosomal Secretion Positive Regulation Of Ubiquitin-dependent Endocytosis	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cellular Respiration Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Brown Fat Cell Differentiation Histone H3-K9 Methylation Heterochromatin Organization Positive Regulation Of Cold-induced Thermogenesis
Pathways		Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy	PKMTs methylate histone lysines
Drugs
Diseases
GWAS			Allergic rhinitis ( 25085501) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive decline (age-related) ( 28078323) Coronary artery disease ( 29212778) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diastolic blood pressure ( 27618448) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Headache ( 29397368) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hypertension ( 31879980) Immature fraction of reticulocytes ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean arterial pressure ( 27618448) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean platelet volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (antimigraine preparations) ( 31015401) Migraine ( 27182965 23793025 21666692 27322543) Monocyte percentage of white cells ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Motion sickness ( 25628336) Nicotine dependence symptom count ( 25555482) Nose morphology ( 29921221) Optic disc size ( 31809533) Periventricular white matter hyperintensities ( 32517579) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) QRS duration ( 25035420) Red blood cell count ( 32888494 27863252) Response to statin therapy ( 20339536) Rheumatoid arthritis ( 30891314) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27618448) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		120 interacting genes: AATF ADRB2 AJUBA AKAP9 AR ARRDC1 BAG4 BCAS3 BCR BIRC2 CAGE1 CBY1 CCDC88B CCHCR1 CCND3 CDKN1A CDKN2D CDS2 CEP55 CEP63 CNOT7 DAXX DMAP1 DMRTB1 DNMT1 DZIP3 EP300 FAM110A FAM9B GGA1 GGA3 GMCL1 GOLM1 HAUS1 HCK HGS HSH2D INCA1 IQGAP1 ITSN1 JUN KIAA1328 KIF5A KIFC3 KLK5 KLK6 KRT13 KRT15 KRT16 KRT18 KRT31 KRT34 KRT35 KRT75 LCN2 LENG8 LNX1 LRSAM1 MDM2 MGRN1 MKRN3 MTA3 MZB1 NR3C1 PDCD6IP PDLIM7 PIAS1 PKNOX2 PPFIBP2 PPP1R13B PRDM16 PRSS50 QKI RAD18 RASL10B RBPMS RNF111 RNF126 RNF41 ROCK1 SCAMP3 SCARA5 SCGB3A1 SCNN1A SH3GLB2 SNAPIN SNF8 SNX32 STK11 SYCE1 TAX1BP1 TEX11 TFF1 TFIP11 THRB THRSP TNIP1 TNIP2 TNNT3 TOM1L1 TP53 TRAIP TRIM23 TRIM35 TRIM46 TRIM54 TRIM74 TRIML2 UBA52 UBC USHBP1 VPS11 VPS28 VPS36 VPS37A VPS37B VPS37C VPS37D WASHC1 ZWINT	22 interacting genes: ACOT8 ARRB1 CCDC13 CFAP206 DDX6 GLMN LENG8 LONRF1 MID2 MIPOL1 NEK6 PATJ PLK4 POLR3C RBBP4 RIOK2 RUNX1T1 TCHP TEX10 TSG101 TXLNA XPA
Entrez ID		7251	63976
HPRD ID		03229	16122
Ensembl ID		ENSG00000074319	ENSG00000142611
Uniprot IDs		Q99816	Q9HAZ2
PDB IDs		1KPP 1KPQ 1M4P 1M4Q 1S1Q 2F0R 3IV1 3OBQ 3OBS 3OBU 3OBX 3P9G 3P9H 4EJE 4YC1 4ZNY 5VKG 6VME	2N1I 6BW4
Enriched GO Terms of Interacting Partners?
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