TFE3 and LAMTOR3

Data Source:
BioGRID (two hybrid)

		TFE3	LAMTOR3
Description		transcription factor binding to IGHM enhancer 3	late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol	Lysosomal Membrane Plasma Membrane Focal Adhesion Endosome Membrane Specific Granule Membrane Extracellular Exosome Tertiary Granule Membrane Ragulator Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Kinase Activator Activity Molecular Adaptor Activity
	Biological Process	Adaptive Immune Response Regulation Of Transcription By RNA Polymerase II Humoral Immune Response Regulation Of Osteoclast Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Brown Fat Cell Differentiation Negative Regulation Of Cold-induced Thermogenesis	MAPK Cascade Activation Of MAPKK Activity Cell Cycle Arrest Regulation Of Macroautophagy Positive Regulation Of TOR Signaling Cellular Protein Localization Neutrophil Degranulation Cellular Response To Amino Acid Stimulus Protein Localization To Cell Junction
Pathways			Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes MAP2K and MAPK activation Neutrophil degranulation Regulation of PTEN gene transcription Amino acids regulate mTORC1
Drugs
Diseases		Alveolar soft part sarcoma Renal cell carcinoma
GWAS			Mean reticulocyte volume ( 32888494)
Interacting Genes		10 interacting genes: E2F3 HMGB1 LAMTOR3 MITF SMAD3 SMAD4 SMARCE1 TFEB TFEC YWHAG	20 interacting genes: ADAMTS10 APOL6 BHMT CEBPZ CPNE6 IBTK LAMTOR2 MAP2K1 MAP2K2 MAPK1 MAPK3 MBD2 NIF3L1 PDE4DIP QARS1 SUFU TFE3 TGM7 UBR1 ZSCAN4
Entrez ID		7030	8649
HPRD ID		02439	04485
Ensembl ID		ENSG00000068323	ENSG00000109270
Uniprot IDs		A0A024QZ23 B4DIA5 P19532	Q9UHA4
PDB IDs			1SKO 2ZL1 3CPT 5X6U 5X6V 5Y39 5Y3A 6B9X 6EHP 6EHR 6NZD 6U62 6ULG 6WJ2 6WJ3
Enriched GO Terms of Interacting Partners?
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