TFE3 and E2F3

Data Source:
BioGRID (two hybrid, pull down, affinity chromatography technology)
HPRD (in vivo, two hybrid, in vitro)

		TFE3	E2F3
Description		transcription factor binding to IGHM enhancer 3	E2F transcription factor 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol	Chromatin Nucleus Nucleoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Adaptive Immune Response Regulation Of Transcription By RNA Polymerase II Humoral Immune Response Regulation Of Osteoclast Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Brown Fat Cell Differentiation Negative Regulation Of Cold-induced Thermogenesis	G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Protein Import Into Nucleus Positive Regulation Of Cell Population Proliferation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Fat Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process
Pathways			Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Oncogene Induced Senescence CDC6 association with the ORC:origin complex G2 Phase Cyclin D associated events in G1 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drugs
Diseases		Alveolar soft part sarcoma Renal cell carcinoma
GWAS			Adult body size ( 32376654) Estimated glomerular filtration rate in non-diabetics ( 31451708) Metabolite levels ( 23823483) Molybdenum levels ( 26025379) Obesity-related traits ( 23251661) Triglyceride levels ( 32203549)
Interacting Genes		10 interacting genes: E2F3 HMGB1 LAMTOR3 MITF SMAD3 SMAD4 SMARCE1 TFEB TFEC YWHAG	25 interacting genes: ATAD2 CCNA2 CDK3 CREBBP DNMT3L FHL2 FZR1 HCFC1 HELLS MGA MYBL2 PKIB RB1 RNF144A RYBP SP1 SPIB SRA1 TEAD3 TFDP1 TFDP2 TFE3 UCHL5 WNK1 YY1
Entrez ID		7030	1871
HPRD ID		02439	02693
Ensembl ID		ENSG00000068323	ENSG00000112242
Uniprot IDs		A0A024QZ23 B4DIA5 P19532	O00716
PDB IDs
Enriched GO Terms of Interacting Partners?
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