LAMTOR3 and LAMTOR2

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		LAMTOR3	LAMTOR2
Description		late endosomal/lysosomal adaptor, MAPK and MTOR activator 3	late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
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GO Annotations	Cellular Component	Lysosomal Membrane Plasma Membrane Focal Adhesion Endosome Membrane Specific Granule Membrane Extracellular Exosome Tertiary Granule Membrane Ragulator Complex	Lysosomal Membrane Late Endosome Plasma Membrane Endosome Membrane Specific Granule Membrane Tertiary Granule Membrane Ragulator Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Kinase Activator Activity Molecular Adaptor Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding Molecular Adaptor Activity
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Cell Cycle Arrest Regulation Of Macroautophagy Positive Regulation Of TOR Signaling Cellular Protein Localization Neutrophil Degranulation Cellular Response To Amino Acid Stimulus Protein Localization To Cell Junction	MAPK Cascade Activation Of MAPKK Activity Regulation Of Cell Growth Cell Cycle Arrest Fibroblast Migration Regulation Of Macroautophagy Positive Regulation Of TOR Signaling Cellular Protein Localization Neutrophil Degranulation Cellular Response To Amino Acid Stimulus Regulation Of Cell-substrate Junction Organization Protein Localization To Cell Junction
Pathways		Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes MAP2K and MAPK activation Neutrophil degranulation Regulation of PTEN gene transcription Amino acids regulate mTORC1	Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes MAP2K and MAPK activation Neutrophil degranulation Regulation of PTEN gene transcription Amino acids regulate mTORC1
Drugs
Diseases
GWAS		Mean reticulocyte volume ( 32888494)
Interacting Genes		20 interacting genes: ADAMTS10 APOL6 BHMT CEBPZ CPNE6 IBTK LAMTOR2 MAP2K1 MAP2K2 MAPK1 MAPK3 MBD2 NIF3L1 PDE4DIP QARS1 SUFU TFE3 TGM7 UBR1 ZSCAN4	3 interacting genes: BORCS6 ERBB3 LAMTOR3
Entrez ID		8649	28956
HPRD ID		04485	17463
Ensembl ID		ENSG00000109270	ENSG00000116586
Uniprot IDs		Q9UHA4	Q9Y2Q5
PDB IDs		1SKO 2ZL1 3CPT 5X6U 5X6V 5Y39 5Y3A 6B9X 6EHP 6EHR 6NZD 6U62 6ULG 6WJ2 6WJ3	5X6U 5X6V 5Y39 5Y3A 6B9X 6EHP 6EHR 6NZD 6U62 6ULG 6WJ2 6WJ3
Enriched GO Terms of Interacting Partners?
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