PRDX2 and CA4

Data Source:
BioGRID (two hybrid)

		PRDX2	CA4
Description		peroxiredoxin 2	carbonic anhydrase 4
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GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Rough Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Trans-Golgi Network Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Transport Vesicle Membrane Secretory Granule Membrane Anchored Component Of External Side Of Plasma Membrane Brush Border Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding Thioredoxin Peroxidase Activity Antioxidant Activity	Carbonate Dehydratase Activity Protein Binding Zinc Ion Binding Hydro-lyase Activity
	Biological Process	Activation Of MAPK Activity Respiratory Burst Involved In Inflammatory Response Response To Oxidative Stress Regulation Of Hydrogen Peroxide Metabolic Process Removal Of Superoxide Radicals Positive Regulation Of Blood Coagulation Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Lipopolysaccharide Cellular Response To Stress Cellular Response To Oxidative Stress T Cell Proliferation Hydrogen Peroxide Catabolic Process Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Leukocyte Activation Cell Redox Homeostasis Negative Regulation Of T Cell Differentiation Thymus Development Homeostasis Of Number Of Cells Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	One-carbon Metabolic Process Bicarbonate Transport
Pathways		Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide Reversible hydration of carbon dioxide
Drugs		3-sulfino-L-alanine N-Carbamoyl-Alanine Copper	Methyclothiazide Topiramate Ethoxzolamide Bendroflumethiazide Benzthiazide Benzthiazide Cyclothiazide Methazolamide Hydroflumethiazide Acetazolamide Dorzolamide Zonisamide Trichlormethiazide Diclofenamide Brinzolamide Ellagic acid Sodium carbonate
Diseases			Retinitis pigmentosa (RP)
GWAS		Platelet distribution width ( 32888494)
Interacting Genes		24 interacting genes: A2M APOE APP BAD CA4 CD320 CDC37 COPS5 ECSIT EXOC6 IFIT5 MAST1 NLGN3 PDGFRB PPP2R1A PPP2R1B PRDX4 PSEN1 RNF32 SAT1 SUMO4 TXNDC5 UTY YWHAZ	5 interacting genes: PIH1D1 PRDX2 SLC4A1 SLC4A3 SLC4A4
Entrez ID		7001	762
HPRD ID		02763	00261
Ensembl ID		ENSG00000167815	ENSG00000167434
Uniprot IDs		P32119 V9HW12	P22748
PDB IDs		1QMV 5B8A 5B8B 5IJT	1ZNC 3F7B 3F7U 3FW3 5IPZ 5JN8 5JN9 5JNA 5JNC 5KU6
Enriched GO Terms of Interacting Partners?
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