TAF7 and TRIM24

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro)

		TAF7	TRIM24
Description		TATA-box binding protein associated factor 7	tripartite motif containing 24
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GO Annotations	Cellular Component	Nucleoplasm Transcription Regulator Complex Transcription Factor TFIID Complex Cytoplasm Transcription Factor TFTC Complex MLL1 Complex	Euchromatin Nucleus Nucleoplasm Perichromatin Fibrils Cytosol
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding TFIIH-class Transcription Factor Complex Binding Protein Binding Transcription Factor Binding RNA Polymerase II General Transcription Initiation Factor Activity Histone Acetyltransferase Binding Vitamin D Receptor Binding Thyroid Hormone Receptor Binding Protein Heterodimerization Activity H3K27me3 Modified Histone Binding P-TEFb Complex Binding	P53 Binding Chromatin Binding Transcription Coactivator Activity Protein Kinase Activity Signaling Receptor Binding Protein Binding Zinc Ion Binding Nuclear Receptor Binding Estrogen Response Element Binding Methylated Histone Binding Ubiquitin Protein Ligase Activity Lysine-acetylated Histone Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Spermine Transport DNA-templated Transcription, Initiation Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Protein Kinase Activity Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Histone Acetylation Negative Regulation Of MHC Class I Biosynthetic Process Negative Regulation Of MHC Class II Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Negative Regulation Of Histone H4 Acetylation Regulation Of Signal Transduction By P53 Class Mediator	Transcription By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Protein Ubiquitination Protein Catabolic Process Regulation Of Protein Stability Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Calcium Ion Homeostasis Regulation Of Vitamin D Receptor Signaling Pathway Cellular Response To Estrogen Stimulus Regulation Of Signal Transduction By P53 Class Mediator
Pathways		HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance	Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease Signaling by BRAF and RAF fusions
Drugs
Diseases
GWAS		Mean platelet volume ( 32888494 27863252) Refractive error ( 32231278)	Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Quantitative traits ( 19197348)
Interacting Genes		27 interacting genes: AHR CDK7 CDK9 CPSF1 FAU GATA1 H3-4 HSF1 IKBKG MAP1LC3B RBM6 SETD7 TAF1 TAF10 TAF11 TAF12 TAF15 TAF2 TAF4 TAF5 TAF6 TAF8 TAF9 TRIM22 TRIM24 YWHAE ZSCAN1	49 interacting genes: AR ATF4 BRCA1 BRD7 CBX1 CBX3 CBX5 ESR1 ESR2 FOSL1 GTF2E1 H3C10 H3C11 H3C12 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 HNF4A HSPA1A HSPB1 MTNR1B NFE2L2 NR2F2 NR3C1 NR3C2 PGR PML PPARG RARA RNF141 RNF181 RXRA STAT6 SUMO1 TAF11 TAF1B TAF1C TAF7 THRA TRIM28 TRIM33 TRIM8 UBE2I UBE2U VDR ZNF10
Entrez ID		6879	8805
HPRD ID		07196	04556
Ensembl ID		ENSG00000178913	ENSG00000122779
Uniprot IDs		Q15545	A0A024R784 O15164
PDB IDs		4RGW 5FUR 6MZL 6MZM	2YYN 3O33 3O34 3O35 3O36 3O37 4YAB 4YAD 4YAT 4YAX 4YBM 4YBS 4YBT 4YC9 4ZQL 5H1T 5H1U 5H1V
Enriched GO Terms of Interacting Partners?
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