TRIM24 and VDR

Data Source:
HPRD (in vivo)

		TRIM24	VDR
Description		tripartite motif containing 24	vitamin D receptor
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GO Annotations	Cellular Component	Euchromatin Nucleus Nucleoplasm Perichromatin Fibrils Cytosol	Chromatin Nucleus Nucleoplasm Cytosol Receptor Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	P53 Binding Chromatin Binding Transcription Coactivator Activity Protein Kinase Activity Signaling Receptor Binding Protein Binding Zinc Ion Binding Nuclear Receptor Binding Estrogen Response Element Binding Methylated Histone Binding Ubiquitin Protein Ligase Activity Lysine-acetylated Histone Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Lithocholic Acid Receptor Activity Retinoid X Receptor Binding Vitamin D Response Element Binding Calcitriol Binding Lithocholic Acid Binding
	Biological Process	Transcription By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Protein Ubiquitination Protein Catabolic Process Regulation Of Protein Stability Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Calcium Ion Homeostasis Regulation Of Vitamin D Receptor Signaling Pathway Cellular Response To Estrogen Stimulus Regulation Of Signal Transduction By P53 Class Mediator	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Transcription Initiation From RNA Polymerase II Promoter Multicellular Organism Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Keratinocyte Proliferation Positive Regulation Of Vitamin D 24-hydroxylase Activity Cell Differentiation Bile Acid Signaling Pathway Vitamin D Metabolic Process Positive Regulation Of Keratinocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Decidualization Regulation Of Calcidiol 1-monooxygenase Activity Vitamin D Receptor Signaling Pathway
Pathways		Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease Signaling by BRAF and RAF fusions	Vitamin D (calciferol) metabolism Nuclear Receptor transcription pathway SUMOylation of intracellular receptors
Drugs			Calcitriol Calcifediol Ergocalciferol Cholecalciferol Paricalcitol Dihydrotachysterol Alfacalcidol Calcipotriol Lexacalcitol Seocalcitol Cholesterol Inecalcitol Becocalcidiol CTA018 Eldecalcitol Elocalcitol Doxercalciferol (1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diol 1,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z) Vitamin D Curcumin Curcumin sulfate
Diseases			Tuberculosis Localized autosomal recessive hypotrichosis
GWAS		Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Quantitative traits ( 19197348)	Asthma (adult onset) ( 31036433) Eosinophil percentage of white cells ( 32888494) Gout ( 22179738) Gut microbiota (beta diversity) ( 27723756) Inflammatory bowel disease ( 23128233) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Menarche (age at onset) ( 25231870) Serum immune biomarker levels ( 32066700)
Interacting Genes		49 interacting genes: AR ATF4 BRCA1 BRD7 CBX1 CBX3 CBX5 ESR1 ESR2 FOSL1 GTF2E1 H3C10 H3C11 H3C12 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 HNF4A HSPA1A HSPB1 MTNR1B NFE2L2 NR2F2 NR3C1 NR3C2 PGR PML PPARG RARA RNF141 RNF181 RXRA STAT6 SUMO1 TAF11 TAF1B TAF1C TAF7 THRA TRIM28 TRIM33 TRIM8 UBE2I UBE2U VDR ZNF10	79 interacting genes: ACTN4 ACVR1 ANKRD11 BAG1 CCND3 CDCA7L CDK7 CFH CLASRP COPS2 CREBBP CSNK2A1 CXXC5 FGR FOS FOXO3 GABARAPL1 GABARAPL2 GNPAT GOLM2 GRIP1 GTF2B HMGN3 HR JUN KDM5A LCOR MAPK1 MAPK3 MED1 MED12 MED14 MED23 MEOX2 MMRN2 MYC NCOA1 NCOA2 NCOA3 NCOA4 NCOA6 NCOR1 NCOR2 NKD2 NLRP3 NR0B2 NR1H2 NRIP1 NSD1 NTAQ1 OTUD4 POLR2A POU1F1 POU2F1 PPARG PPP1CA PPP2CA PRCP PRKCSH PSMC5 RB1 RNF14 RPS6KC1 RUNX1 RUNX1T1 RXRA RXRB RXRG SIRT1 SMAD3 SNW1 SRC SRPK1 STAT1 TAF11 TDG TRIM24 TRIP13 ZBTB16
Entrez ID		8805	7421
HPRD ID		04556	03463
Ensembl ID		ENSG00000122779	ENSG00000111424
Uniprot IDs		A0A024R784 O15164	F1D8P8 P11473
PDB IDs		2YYN 3O33 3O34 3O35 3O36 3O37 4YAB 4YAD 4YAT 4YAX 4YBM 4YBS 4YBT 4YC9 4ZQL 5H1T 5H1U 5H1V	1DB1 1IE8 1IE9 1KB2 1KB4 1KB6 1S0Z 1S19 1TXI 1YNW 2HAM 2HAR 2HAS 2HB7 2HB8 3A2I 3A2J 3A3Z 3A40 3A78 3AUQ 3AUR 3AX8 3AZ1 3AZ2 3AZ3 3B0T 3CS4 3CS6 3KPZ 3M7R 3OGT 3P8X 3TKC 3VHW 3W0A 3W0C 3W0Y 3WGP 3WWR 3X31 3X36 4G2I 4ITE 4ITF 5GT4 5V39 5YSY 5YT2
Enriched GO Terms of Interacting Partners?
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