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STAT3 and PINK1
Data Source:
BioGRID
(two hybrid)
STAT3
PINK1
Description
signal transducer and activator of transcription 3
PTEN induced kinase 1
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Cytosol
Plasma Membrane
RNA Polymerase II Transcription Regulator Complex
Chromatin
Nucleus
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Mitochondrial Inner Membrane
Mitochondrial Intermembrane Space
Endoplasmic Reticulum
Cytosol
Cytoskeleton
Membrane
Axon
Growth Cone
Integral Component Of Mitochondrial Outer Membrane
Cell Body
Perinuclear Region Of Cytoplasm
Lewy Body
Astrocyte Projection
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Repressing Transcription Factor Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Nuclear Receptor Activity
Protein Binding
Transcription Factor Binding
Protein Kinase Binding
Protein Phosphatase Binding
Chromatin DNA Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Dimerization Activity
Primary MiRNA Binding
Magnesium Ion Binding
Protease Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Calcium-dependent Protein Kinase Activity
Kinase Activity
Peptidase Activator Activity
Ubiquitin Protein Ligase Binding
Protein Kinase B Binding
Protein-containing Complex Binding
C3HC4-type RING Finger Domain Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
TORC2 Complex Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Temperature Homeostasis
Eye Photoreceptor Cell Differentiation
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Protein Import Into Nucleus
Defense Response
Inflammatory Response
Signal Transduction
Receptor Signaling Pathway Via JAK-STAT
Nervous System Development
Negative Regulation Of Autophagy
Positive Regulation Of Gene Expression
Viral Process
Phosphorylation
Cytokine-mediated Signaling Pathway
Sexual Reproduction
Positive Regulation Of Cell Migration
Intracellular Receptor Signaling Pathway
Response To Estradiol
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Cellular Response To Hormone Stimulus
Leptin-mediated Signaling Pathway
Somatic Stem Cell Population Maintenance
Interleukin-15-mediated Signaling Pathway
Interleukin-7-mediated Signaling Pathway
Interleukin-9-mediated Signaling Pathway
Interleukin-21-mediated Signaling Pathway
Interleukin-23-mediated Signaling Pathway
Regulation Of Cell Population Proliferation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Glucose Homeostasis
Eating Behavior
Response To Peptide Hormone
Cellular Response To Leptin Stimulus
Response To Leptin
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Astrocyte Differentiation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Cell Cycle
Radial Glial Cell Differentiation
Regulation Of Feeding Behavior
Growth Hormone Receptor Signaling Pathway
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Interleukin-6-mediated Signaling Pathway
Interleukin-27-mediated Signaling Pathway
Interleukin-35-mediated Signaling Pathway
Cellular Response To Cytokine Stimulus
T-helper 17 Type Immune Response
T-helper 17 Cell Lineage Commitment
Energy Homeostasis
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Positive Regulation Of Metalloendopeptidase Activity
Positive Regulation Of MiRNA Mediated Inhibition Of Translation
Negative Regulation Of Primary MiRNA Processing
Positive Regulation Of Gene Silencing By MiRNA
Autophagy Of Mitochondrion
Positive Regulation Of Protein Phosphorylation
Regulation Of Oxidative Phosphorylation
Response To Ischemia
Protein Phosphorylation
Ubiquitin-dependent Protein Catabolic Process
Response To Oxidative Stress
Mitochondrion Organization
Regulation Of Hydrogen Peroxide Metabolic Process
Negative Regulation Of Gene Expression
Regulation Of Mitochondrion Organization
Positive Regulation Of Peptidase Activity
Macroautophagy
Positive Regulation Of Macroautophagy
Negative Regulation Of Macroautophagy
Protein Ubiquitination
Peptidyl-serine Phosphorylation
Respiratory Electron Transport Chain
Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Ubiquitination
Activation Of Protein Kinase B Activity
Positive Regulation Of Synaptic Transmission, Dopaminergic
Positive Regulation Of Peptidyl-serine Phosphorylation
Positive Regulation Of Dopamine Secretion
Cellular Response To Oxidative Stress
Positive Regulation Of Protein Dephosphorylation
Intracellular Signal Transduction
Peptidyl-serine Autophosphorylation
TORC2 Signaling
Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Protein-containing Complex Assembly
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Translation
Negative Regulation Of JNK Cascade
Protein Stabilization
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Mitochondrial Membrane Potential
Positive Regulation Of Protein Kinase B Signaling
Regulation Of Proteasomal Protein Catabolic Process
Cellular Response To Hypoxia
Establishment Of Protein Localization To Mitochondrion
Maintenance Of Protein Location In Mitochondrion
Positive Regulation Of Mitochondrial Fission
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Negative Regulation Of Mitochondrial Fission
Cellular Response To Toxic Substance
Positive Regulation Of Mitophagy In Response To Mitochondrial Depolarization
Mitochondrion To Lysosome Transport
Regulation Of Cellular Response To Oxidative Stress
Positive Regulation Of Histone Deacetylase Activity
Regulation Of Synaptic Vesicle Transport
Negative Regulation Of Autophagosome Assembly
Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone
Regulation Of Autophagy Of Mitochondrion
Negative Regulation Of Autophagy Of Mitochondrion
Negative Regulation Of Oxidative Stress-induced Cell Death
Negative Regulation Of Oxidative Stress-induced Neuron Death
Regulation Of Protein Targeting To Mitochondrion
Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide
Positive Regulation Of Cristae Formation
Positive Regulation Of Protein Targeting To Mitochondrion
Positive Regulation Of Free Ubiquitin Chain Polymerization
Positive Regulation Of NMDA Glutamate Receptor Activity
Cellular Response To Hydrogen Sulfide
Regulation Of Reactive Oxygen Species Metabolic Process
Negative Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of ATP Biosynthetic Process
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Interleukin-6 signaling
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Interleukin-7 signaling
Interleukin-7 signaling
Signaling by SCF-KIT
Signaling by cytosolic FGFR1 fusion mutants
Downstream signal transduction
Signalling to STAT3
Senescence-Associated Secretory Phenotype (SASP)
Signaling by Leptin
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Association of TriC/CCT with target proteins during biosynthesis
Transcriptional regulation of pluripotent stem cells
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
PTK6 Activates STAT3
PTK6 Activates STAT3
Interleukin-20 family signaling
MET activates STAT3
MET activates STAT3
Interleukin-15 signaling
Interleukin-35 Signalling
Interleukin-9 signaling
Interleukin-37 signaling
Interleukin-23 signaling
Interleukin-23 signaling
Interleukin-27 signaling
Interleukin-21 signaling
Transcriptional regulation of granulopoiesis
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Growth hormone receptor signaling
PINK1-PRKN Mediated Mitophagy
FOXO-mediated transcription of cell death genes
Drugs
ENMD-1198
Diseases
Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
Oral cancer
Parkinson's disease (PD)
GWAS
Apolipoprotein B levels (
32203549
)
Atopic dermatitis (
26482879
)
Autoimmune thyroid disease (
32581359
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Composite immunoglobulin trait (IgA/IgG) (
28628107
)
Crohn's disease (
18587394
28067908
21102463
23266558
)
Crohn's disease or systemic sclerosis (
32024964
)
Diastolic blood pressure (
30578418
)
Inflammatory bowel disease (
27569725
28067908
26278503
23128233
)
Itch intensity from mosquito bite (
28199695
)
Itch intensity from mosquito bite adjusted by bite size (
28199695
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
27863252
)
Mean spheric corpuscular volume (
32888494
)
Multiple sclerosis (
31604244
22190364
24076602
21833088
20159113
)
Psoriasis (
25903422
23143594
)
Systemic lupus erythematosus (
28714469
)
Type 2 diabetes (
30054458
)
Ulcerative colitis (
28067908
)
Household income (MTAG) (
31844048
)
Itch intensity from mosquito bite adjusted by bite size (
28199695
)
Paclitaxel disposition in epithelial ovarian cancer (
29367611
)
Proportion of activated microglia (inferior temporal cortex) (
30679421
)
Interacting Genes
208 interacting genes:
ABL2
ADRB2
AMBP
AR
ARFIP2
ASXL1
ATF3
BATF3
BCKDK
BHLHE40
BICD1
BLK
BMX
BRCA1
BRWD1
CA8
CAPN1
CAPNS1
CBL
CCDC87
CCND1
CCR1
CCR5
CDK9
CDKN1A
CEP120
CHTF18
CNDP2
CORO1A
CREBBP
CSF2RB
CSF3R
CXCR4
DAXX
DOK2
DOK3
DTNA
ECH1
EGFR
EIF2AK2
ELP2
EP300
EPHA3
ERBB2
ERBIN
ESR1
FAM117B
FBXW7
FER
FES
FGFR3
FGFR4
FGR
FHL2
FLT1
FOXM1
FYN
GATA1
GATA2
GHR
GNL3
GSTCD
GTF2I
HCK
HDAC1
HDAC2
HDAC3
HES1
HES5
HESX1
HIF1A
HIVEP1
HLA-A
HNF1A
HNRNPM
HOXC11
HSP90AA1
HSP90AB1
IFNAR1
IFNAR2
IGF1R
IL1RAP
IL22RA1
IL23R
IL2RA
IL2RB
IL6R
IL6ST
IL7R
IMPDH2
IRAK1
JAK1
JAK2
JAK3
JUN
KAT5
KDM1A
KHDRBS1
KLF15
KPNA1
KPNA6
KRTAP10-7
LAMB2
LASP1
LCK
LEPR
LMO2
LYN
MAP3K13
MAP3K7
MAPK1
MAPK3
MAPK8
MAPKAPK2
MEG3
MET
MNDA
MORC4
MPZL1
MRPS31
MTOR
MYOD1
NACAD
NCOA1
NDUFA13
NFKB1
NFKBIZ
NIF3L1
NLK
NMI
NR3C1
NR4A1
NUFIP2
NXT2
OFCC1
OGDHL
PAFAH1B2
PAQR7
PCBD2
PDGFRA
PDGFRB
PDIA3
PELP1
PIAS3
PIK3R1
PIK3R2
PIK3R3
PINK1
PML
POM121
PPARD
PRKCD
PTK2B
PTMA
PTPN1
PTPN11
PTPN2
RABGAP1
RAC1
RACK1
RB1
RELA
RET
RPA2
RPL11
RPS6KA5
RPS9
RRAD
SCAF11
SETD7
SH2D2A
SH3BP2
SIAH2
SIN3A
SMARCA4
SPRY1
SRC
SRI
SRRT
SS18L1
STAP2
STAT1
STAT4
STAT5A
STAT5B
STAT6
STMN1
SULT2A1
SUMO4
SUPT20H
SYK
TASOR2
TDG
TM4SF19
TRIM28
TRIP10
TSHR
TSLP
TWIST1
VPS39
WDFY3
ZFPM2
ZNF148
ZNF281
ZNF467
ZNF557
ZNF829
ZNRD2
16 interacting genes:
APPL2
BAG2
BAG5
CRLS1
DNM1L
FBXO7
HSH2D
MAP3K7
MARK2
NEAT1
PARK7
SNCAIP
STAT3
TGM2
TRAF6
UBE2M
Entrez ID
6774
65018
HPRD ID
00026
10514
Ensembl ID
ENSG00000168610
ENSG00000158828
Uniprot IDs
P40763
Q9BXM7
PDB IDs
5AX3
5U5S
6NJS
6NUQ
6QHD
6TLC
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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