Description |
signal transducer and activator of transcription 3 |
estrogen receptor 1 |
Image |
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Cellular Component |
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Molecular Function |
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Biological Process |
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Pathways |
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Drugs |
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- Diethylstilbestrol
- Chlorotrianisene
- Conjugated estrogens
- Desogestrel
- Levonorgestrel
- Progesterone
- Lindane
- Raloxifene
- Toremifene
- Medroxyprogesterone acetate
- Testosterone
- Mitotane
- Estrone
- Tamoxifen
- Hexachlorophene
- Estradiol
- Ethynodiol diacetate
- Dobutamine
- Clomifene
- Dienestrol
- Fulvestrant
- Norgestimate
- Ethinylestradiol
- Melatonin
- Trilostane
- Naloxone
- Fluoxymesterone
- Estramustine
- Mestranol
- Danazol
- Oxybenzone
- Allylestrenol
- Zinc
- Genistein
- Prasterone
- Benzophenone
- Equilin
- Compound 19
- Resveratrol
- Compound 18
- Phthalic Acid
- Pyrazole
- Stanolone
- Naringenin
- Compound 4-D
- 1-[4-(Octahydro-Pyrido[1,2-a]Pyrazin-2-Yl)-Phenyl]-2-Phenyl-1,2,3,4-Tetrahydro-Isoquinolin-6-Ol
- Quercetin
- Afimoxifene
- 2-Phenyl-1-[4-(2-Piperidin-1-Yl-Ethoxy)-Phenyl]-1,2,3,4-Tetrahydro-Isoquinolin-6-Ol
- Estriol
- Estrone sulfate
- Quinestrol
- Phenolphthalein
- Permethrin
- Ospemifene
- AP1081
- Custirsen
- NP-50301
- CHF 4227
- TAS-108
- Lasofoxifene
- Arzoxifene
- Elacestrant
- Bazedoxifene
- Methyltestosterone
- beta-Naphthoflavone
- 17-METHYL-17-ALPHA-DIHYDROEQUILENIN
- 4-(2-amino-1-methyl-1H-imidazo[4,5-b]pyridin-6-yl)phenol
- [5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE
- 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-8-METHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL
- 4-[(1S,2S,5S,9R)-5-(HYDROXYMETHYL)-8,9-DIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL
- 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-6,8,9-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL
- (2R,3R,4S)-3-(4-HYDROXYPHENYL)-4-METHYL-2-[4-(2-PYRROLIDIN-1-YLETHOXY)PHENYL]CHROMAN-6-OL
- (3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL
- (9ALPHA,13BETA,17BETA)-2-[(1Z)-BUT-1-EN-1-YL]ESTRA-1,3,5(10)-TRIENE-3,17-DIOL
- (9BETA,11ALPHA,13ALPHA,14BETA,17ALPHA)-11-(METHOXYMETHYL)ESTRA-1(10),2,4-TRIENE-3,17-DIOL
- 3-CHLORO-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL
- 3-ETHYL-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL
- Hexestrol
- dimethyl (1R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate
- Erteberel
- N-[(1R)-3-(4-HYDROXYPHENYL)-1-METHYLPROPYL]-2-(2-PHENYL-1H-INDOL-3-YL)ACETAMIDE
- (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL
- 4-[1-allyl-7-(trifluoromethyl)-1H-indazol-3-yl]benzene-1,3-diol
- 4-(6-HYDROXY-1H-INDAZOL-3-YL)BENZENE-1,3-DIOL
- DIETHYL (1R,2S,3R,4S)-5,6-BIS(4-HYDROXYPHENYL)-7-OXABICYCLO[2.2.1]HEPT-5-ENE-2,3-DICARBOXYLATE
- 2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
- 4-[(1S,2R,5S)-4,4,8-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL
- (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-9-OL
- 2-(4-hydroxyphenyl)benzo[b]thiophen-6-ol
- Tibolone
- Eugenol
- Synthetic Conjugated Estrogens, A
- Synthetic Conjugated Estrogens, B
- Polyestradiol phosphate
- Norethynodrel
- Octocrylene
- Homosalate
- Enzacamene
- Zeranol
- Ractopamine
- Gestrinone
- Propyl Gallate
- 2-Methoxy-6-{(E)-[(4-methylphenyl)imino]methyl}phenol
- Testosterone cypionate
- Testosterone enanthate
- Testosterone undecanoate
- Stanolone acetate
- Estradiol acetate
- Estradiol benzoate
- Estradiol cypionate
- Estradiol dienanthate
- Estradiol valerate
- Zinc acetate
- Zinc chloride
- Zinc sulfate, unspecified form
- Estriol tripropionate
- Fluoroestradiol F-18
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Diseases |
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GWAS |
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Interacting Genes |
208 interacting genes:
ABL2
ADRB2
AMBP
AR
ARFIP2
ASXL1
ATF3
BATF3
BCKDK
BHLHE40
BICD1
BLK
BMX
BRCA1
BRWD1
CA8
CAPN1
CAPNS1
CBL
CCDC87
CCND1
CCR1
CCR5
CDK9
CDKN1A
CEP120
CHTF18
CNDP2
CORO1A
CREBBP
CSF2RB
CSF3R
CXCR4
DAXX
DOK2
DOK3
DTNA
ECH1
EGFR
EIF2AK2
ELP2
EP300
EPHA3
ERBB2
ERBIN
ESR1
FAM117B
FBXW7
FER
FES
FGFR3
FGFR4
FGR
FHL2
FLT1
FOXM1
FYN
GATA1
GATA2
GHR
GNL3
GSTCD
GTF2I
HCK
HDAC1
HDAC2
HDAC3
HES1
HES5
HESX1
HIF1A
HIVEP1
HLA-A
HNF1A
HNRNPM
HOXC11
HSP90AA1
HSP90AB1
IFNAR1
IFNAR2
IGF1R
IL1RAP
IL22RA1
IL23R
IL2RA
IL2RB
IL6R
IL6ST
IL7R
IMPDH2
IRAK1
JAK1
JAK2
JAK3
JUN
KAT5
KDM1A
KHDRBS1
KLF15
KPNA1
KPNA6
KRTAP10-7
LAMB2
LASP1
LCK
LEPR
LMO2
LYN
MAP3K13
MAP3K7
MAPK1
MAPK3
MAPK8
MAPKAPK2
MEG3
MET
MNDA
MORC4
MPZL1
MRPS31
MTOR
MYOD1
NACAD
NCOA1
NDUFA13
NFKB1
NFKBIZ
NIF3L1
NLK
NMI
NR3C1
NR4A1
NUFIP2
NXT2
OFCC1
OGDHL
PAFAH1B2
PAQR7
PCBD2
PDGFRA
PDGFRB
PDIA3
PELP1
PIAS3
PIK3R1
PIK3R2
PIK3R3
PINK1
PML
POM121
PPARD
PRKCD
PTK2B
PTMA
PTPN1
PTPN11
PTPN2
RABGAP1
RAC1
RACK1
RB1
RELA
RET
RPA2
RPL11
RPS6KA5
RPS9
RRAD
SCAF11
SETD7
SH2D2A
SH3BP2
SIAH2
SIN3A
SMARCA4
SPRY1
SRC
SRI
SRRT
SS18L1
STAP2
STAT1
STAT4
STAT5A
STAT5B
STAT6
STMN1
SULT2A1
SUMO4
SUPT20H
SYK
TASOR2
TDG
TM4SF19
TRIM28
TRIP10
TSHR
TSLP
TWIST1
VPS39
WDFY3
ZFPM2
ZNF148
ZNF281
ZNF467
ZNF557
ZNF829
ZNRD2
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365 interacting genes:
ACTN4
AHR
AKAP13
AKT1
AKT2
ALYREF
ANGPTL4
ANP32B
AR
ARHGEF15
ARID1A
ARNT
ATAD2
BAG1
BAP1
BARD1
BCAR1
BCAS2
BDNF
BRCA1
CALM1
CALM2
CALM3
CAV1
CBLL1
CCND1
CCNH
CCNT1
CCT2
CDC25B
CDK2
CDK7
CDK8
CDKN1A
CEBPA
CEBPB
CFL1
CHD9
CHUK
CITED1
COPS5
CREBBP
CSNK2B
CSRP1
CTNNB1
CUEDC2
CUL4B
CXCL1
DAP3
DARS1
DBN1
DDX1
DDX17
DDX3X
DDX5
DDX54
DHX9
DNMT3L
DNTTIP2
DUT
EEF2
EGFR
EHMT2
EIF2S2
EIF3I
EIF4A3
EP300
EPAS1
EPRS1
EPSTI1
ERBB2
ESR2
ESRRA
FARSA
FBH1
FHL2
FKBP4
FKBP5
FLII
FOXK2
FOXO1
FOXO3
FOXO4
FUBP1
GADD45B
GADD45G
GLCE
GNAI1
GRB2
GRIP1
GRWD1
GTF2B
GTF2H1
H2AC20
H2BC10
H2BC4
H2BC5
H2BC6
H2BC7
H2BC8
H3-3A
H3-3B
HBP1
HDAC3
HDAC4
HDAC5
HDAC9
HDLBP
HEXIM1
HNF4A
HNRNPA1
HNRNPA2B1
HNRNPC
HNRNPD
HSP90AA1
HSP90AB1
HSP90B1
HSPA4
HSPA8
HSPB1
IGF1R
ILF3
ING1
ISL1
ITGB3BP
JUN
JUNB
JUND
KARS1
KAT5
KDM5A
KIF1A
KLF5
KLK5
KLK9
KMT2D
KMT5B
KRT10
KRT18
KRT19
KRT8
LARS1
LCK
LCOR
LDB1
LINC00312
LRIF1
MAPK1
MAPK14
MAPK3
MARS1
MDM2
MED1
MED10
MED12
MED13
MED14
MED16
MED17
MED20
MED21
MED23
MED24
MED27
MED6
MED7
MEN1
MGMT
MKNK2
MMS19
MNAT1
MPG
MSH2
MTA1
MTA2
MTCH2
MTHFD1
MTOR
MUC1
MVP
MYBBP1A
MYH6
NAP1L4
NCL
NCOA1
NCOA2
NCOA3
NCOA4
NCOA6
NCOA7
NCOR1
NCOR2
NELFB
NFKB1
NONO
NPM1
NPPA
NR0B1
NR0B2
NR1H4
NR2C1
NR2C2
NR2F1
NR2F6
NRIP1
NSD1
NSD2
NSD3
NSF
NUDT21
OTUB1
P4HB
PA2G4
PAGR1
PAK1
PAK6
PBXIP1
PDIA3
PELP1
PGC
PGR
PHB
PHB2
PIAS1
PIAS2
PIAS3
PIK3R1
PIK3R3
PNRC2
POLR1B
POLR2A
POLR2D
POU2F1
POU2F2
POU4F1
POU4F2
PPARGC1A
PPARGC1B
PPIB
PPID
PPP1CA
PPP2R1A
PQBP1
PRDM2
PRKACA
PRKCSH
PRMT1
PRMT2
PRPF19
PRPF6
PSMC3IP
PSMC5
PSMD1
PSPC1
PTEN
PTGES3
PTMA
PTPN1
PTPN6
RAC3
RACK1
RANBP9
RARA
RBBP4
RBBP7
RBFOX2
RBM23
RBM39
RELA
REXO4
RFX4
RGS3
RLIM
RNF14
RNF4
RPL9
RPS6KA1
RPS6KA3
RTCB
RXRA
SAFB
SAFB2
SARNP
SARS2
SEPTIN2
SEPTIN8
SERBP1
SERPINB5
SET
SETD7
SFPQ
SHC1
SHMT2
SKIL
SKP2
SLC30A9
SMAD2
SMAD3
SMAD4
SMARCA2
SMARCA4
SMARCD1
SMARCD3
SMARCE1
SMC1A
SMC3
SMYD2
SND1
SNX6
SOS1
SP1
SP3
SRA1
SRC
SREBF1
STAT3
STAT5A
STRN
STUB1
SUV39H1
SVIL
SYNCRIP
TADA3
TAF10
TAF1A
TAF1B
TAF2
TAP1
TBP
TCERG1
TCF20
TDG
THRA
THRB
TNFRSF14
TOPBP1
TP53
TRAM1
TRIM24
TRIM25
TRIM28
TRIM59
TRIP4
TRRAP
TSC2
TUBA1B
TUBA1C
TUBB
TXNRD1
UBE2D3
UBE2I
UBE4B
UIMC1
USF1
VAV3
VCP
WBP2
WIPI1
XBP1
YARS1
YWHAH
YWHAQ
ZBTB16
ZBTB17
ZNF398
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Entrez ID |
6774 |
2099 |
HPRD ID |
00026 |
00589 |
Ensembl ID |
ENSG00000168610
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ENSG00000091831
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Uniprot IDs |
P40763
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A0A125SXW3
A8KAF4
G4XH65
H0Y4W6
P03372
Q9UBT1
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PDB IDs |
5AX3
5U5S
6NJS
6NUQ
6QHD
6TLC
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1A52
1AKF
1ERE
1ERR
1G50
1GWQ
1GWR
1HCP
1HCQ
1L2I
1PCG
1QKT
1QKU
1R5K
1SJ0
1UOM
1X7E
1X7R
1XP1
1XP6
1XP9
1XPC
1XQC
1YIM
1YIN
1ZKY
2AYR
2B1V
2B1Z
2B23
2BJ4
2FAI
2G44
2G5O
2I0J
2IOG
2IOK
2JF9
2JFA
2LLO
2LLQ
2OCF
2OUZ
2P15
2POG
2Q6J
2Q70
2QA6
2QA8
2QAB
2QE4
2QGT
2QGW
2QH6
2QR9
2QSE
2QXM
2QXS
2QZO
2R6W
2R6Y
2YAT
2YJA
3CBM
3CBO
3CBP
3DT3
3ERD
3ERT
3HLV
3HM1
3L03
3OS8
3OS9
3OSA
3Q95
3UU7
3UUA
3UUC
3UUD
4AA6
4DMA
4IU7
4IUI
4IV2
4IV4
4IVW
4IVY
4IW6
4IW8
4IWC
4IWF
4JC3
4JDD
4MG5
4MG6
4MG7
4MG8
4MG9
4MGA
4MGB
4MGC
4MGD
4O6F
4PP6
4PPP
4PPS
4PXM
4Q13
4Q50
4TUZ
4TV1
4XI3
4ZN7
4ZN9
4ZNH
4ZNS
4ZNT
4ZNU
4ZNV
4ZNW
5AAU
5AAV
5ACC
5AK2
5DI7
5DID
5DIE
5DIG
5DK9
5DKB
5DKE
5DKG
5DKS
5DL4
5DLR
5DMC
5DMF
5DP0
5DRJ
5DRM
5DTV
5DU5
5DUE
5DUG
5DUH
5DVS
5DVV
5DWE
5DWG
5DWI
5DWJ
5DX3
5DXB
5DXE
5DXG
5DXK
5DXM
5DXP
5DXQ
5DXR
5DY8
5DYB
5DYD
5DZ0
5DZ1
5DZ3
5DZH
5DZI
5E0W
5E0X
5E14
5E15
5E19
5E1C
5EGV
5EHJ
5EI1
5EIT
5FQP
5FQR
5FQS
5FQT
5FQV
5GS4
5GTR
5HYR
5JMM
5KCC
5KCD
5KCE
5KCF
5KCT
5KCU
5KCW
5KD9
5KR9
5KRA
5KRC
5KRF
5KRH
5KRI
5KRJ
5KRK
5KRL
5KRM
5KRO
5N10
5T0X
5T1Z
5T92
5T97
5TLD
5TLF
5TLG
5TLL
5TLM
5TLO
5TLP
5TLT
5TLU
5TLV
5TLX
5TLY
5TM1
5TM2
5TM3
5TM4
5TM5
5TM6
5TM7
5TM8
5TM9
5TML
5TMM
5TMO
5TMQ
5TMR
5TMS
5TMT
5TMU
5TMV
5TMW
5TMZ
5TN1
5TN3
5TN4
5TN5
5TN6
5TN7
5TN8
5TN9
5TNB
5U2B
5U2D
5UFW
5UFX
5W9C
5W9D
5WGD
5WGQ
6B0F
6C42
6CBZ
6CHW
6CHZ
6CZN
6D0F
6DF6
6DFN
6HHP
6HKB
6HKF
6HMU
6IAR
6OWC
6PET
6PFM
6PIT
6PSJ
6SBO
6SQ0
6SUO
6TJM
6TL3
6V87
6V8T
6VGH
6VIG
6VJ1
6VJD
6VMU
6VPF
6VPK
6VVP
6WOK
7KCD
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Enriched GO Terms of Interacting Partners? |
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Tagcloud ? |
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Tagcloud (Difference) ? |
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Tagcloud (Intersection) ? |
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