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PINK1
Description
PTEN induced kinase 1
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Mitochondrial Inner Membrane
Mitochondrial Intermembrane Space
Endoplasmic Reticulum
Cytosol
Cytoskeleton
Membrane
Axon
Growth Cone
Integral Component Of Mitochondrial Outer Membrane
Cell Body
Perinuclear Region Of Cytoplasm
Lewy Body
Astrocyte Projection
Molecular Function
Magnesium Ion Binding
Protease Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Calcium-dependent Protein Kinase Activity
Kinase Activity
Peptidase Activator Activity
Ubiquitin Protein Ligase Binding
Protein Kinase B Binding
Protein-containing Complex Binding
C3HC4-type RING Finger Domain Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
TORC2 Complex Binding
Biological Process
Autophagy Of Mitochondrion
Positive Regulation Of Protein Phosphorylation
Regulation Of Oxidative Phosphorylation
Response To Ischemia
Protein Phosphorylation
Ubiquitin-dependent Protein Catabolic Process
Response To Oxidative Stress
Mitochondrion Organization
Regulation Of Hydrogen Peroxide Metabolic Process
Negative Regulation Of Gene Expression
Regulation Of Mitochondrion Organization
Positive Regulation Of Peptidase Activity
Macroautophagy
Positive Regulation Of Macroautophagy
Negative Regulation Of Macroautophagy
Protein Ubiquitination
Peptidyl-serine Phosphorylation
Respiratory Electron Transport Chain
Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Ubiquitination
Activation Of Protein Kinase B Activity
Positive Regulation Of Synaptic Transmission, Dopaminergic
Positive Regulation Of Peptidyl-serine Phosphorylation
Positive Regulation Of Dopamine Secretion
Cellular Response To Oxidative Stress
Positive Regulation Of Protein Dephosphorylation
Intracellular Signal Transduction
Peptidyl-serine Autophosphorylation
TORC2 Signaling
Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Protein-containing Complex Assembly
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Translation
Negative Regulation Of JNK Cascade
Protein Stabilization
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Mitochondrial Membrane Potential
Positive Regulation Of Protein Kinase B Signaling
Regulation Of Proteasomal Protein Catabolic Process
Cellular Response To Hypoxia
Establishment Of Protein Localization To Mitochondrion
Maintenance Of Protein Location In Mitochondrion
Positive Regulation Of Mitochondrial Fission
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Negative Regulation Of Mitochondrial Fission
Cellular Response To Toxic Substance
Positive Regulation Of Mitophagy In Response To Mitochondrial Depolarization
Mitochondrion To Lysosome Transport
Regulation Of Cellular Response To Oxidative Stress
Positive Regulation Of Histone Deacetylase Activity
Regulation Of Synaptic Vesicle Transport
Negative Regulation Of Autophagosome Assembly
Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone
Regulation Of Autophagy Of Mitochondrion
Negative Regulation Of Autophagy Of Mitochondrion
Negative Regulation Of Oxidative Stress-induced Cell Death
Negative Regulation Of Oxidative Stress-induced Neuron Death
Regulation Of Protein Targeting To Mitochondrion
Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide
Positive Regulation Of Cristae Formation
Positive Regulation Of Protein Targeting To Mitochondrion
Positive Regulation Of Free Ubiquitin Chain Polymerization
Positive Regulation Of NMDA Glutamate Receptor Activity
Cellular Response To Hydrogen Sulfide
Regulation Of Reactive Oxygen Species Metabolic Process
Negative Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of ATP Biosynthetic Process
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
PINK1-PRKN Mediated Mitophagy
FOXO-mediated transcription of cell death genes
Drugs
Diseases
Parkinson's disease (PD)
GWAS
Household income (MTAG) (
31844048
)
Itch intensity from mosquito bite adjusted by bite size (
28199695
)
Paclitaxel disposition in epithelial ovarian cancer (
29367611
)
Proportion of activated microglia (inferior temporal cortex) (
30679421
)
Interacting Genes
16 interacting genes:
APPL2
BAG2
BAG5
CRLS1
DNM1L
FBXO7
HSH2D
MAP3K7
MARK2
NEAT1
PARK7
SNCAIP
STAT3
TGM2
TRAF6
UBE2M
Entrez ID
65018
HPRD ID
10514
Ensembl ID
ENSG00000158828
Uniprot IDs
Q9BXM7
PDB IDs
Enriched GO Terms of Interacting Partners
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