SMARCB1 and YEATS4

Data Source:
HPRD (in vivo, in vitro)

		SMARCB1	YEATS4
Description		SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	YEATS domain containing 4
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GO Annotations	Cellular Component	Nuclear Chromosome Chromatin Fibrillar Center Nucleus Nucleoplasm Nucleolus SWI/SNF Complex Protein-containing Complex Brahma Complex Intracellular Membrane-bounded Organelle NpBAF Complex NBAF Complex	Nucleus Nucleoplasm Nuclear Matrix Nuclear Membrane NuA4 Histone Acetyltransferase Complex
	Molecular Function	RNA Polymerase I Core Promoter Sequence-specific DNA Binding P53 Binding DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Tat Protein Binding Nucleosomal DNA Binding	Structural Constituent Of Cytoskeleton Protein Binding Protein C-terminus Binding Lysine-acetylated Histone Binding Modification-dependent Protein Binding
	Biological Process	RNA Polymerase I Preinitiation Complex Assembly Nucleosome Disassembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Cell Cycle Nervous System Development DNA Integration Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate ATP-dependent Chromatin Remodeling Positive Regulation By Host Of Viral Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K9 Dimethylation Negative Regulation Of Histone H3-K9 Trimethylation Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Positive Regulation Of Glucose Mediated Signaling Pathway Positive Regulation Of Histone H3-K9 Acetylation Regulation Of Histone H4-K16 Acetylation	Mitotic Cell Cycle Cytoskeleton Organization Regulation Of Growth Histone H4 Acetylation Histone H2A Acetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II
Pathways		RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	HATs acetylate histones Activation of the TFAP2 (AP-2) family of transcription factors
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Fractional shortening ( 29403010) IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis) ( 28878392) IgG digalactosylation phenotypes (multivariate analysis) ( 28878392) IgG disialylation phenotypes (multivariate analysis) ( 28878392) IgG fucosylation phenotypes (multivariate analysis) ( 28878392) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) IgG glycosylation ( 23382691) IgG monogalactosylation phenotypes (multivariate analysis) ( 28878392) IgG N-glycosylation phenotypes (multivariate analysis) ( 28878392 32128391) IgG sialylation phenotypes (multivariate analysis) ( 28878392) N-glycan levels ( 31163085)	Complete remission in asthma ( 29786918) Depressive symptoms x independent stressful life events interaction (1df test) ( 30718454) Height ( 31562340 18391951) Metabolite levels ( 23823483) Response to antidepressants (symptom remission) ( 29160301) Response to diuretic therapy ( 18591461) Response to SSRI in MDD or conscientiouness ( 29559929) Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		112 interacting genes: ABI2 AKT1 APP ARL11 ATP5F1A BCL2L11 BHLHE40 BLZF1 CALR CAMK2D CCDC120 CCDC33 CD69 CDC23 CDX2 CEBPB CHFR CXCL11 CYB5D2 DNAJA3 DPH6 FAM90A1 FAM9B FUS GADD45G GATA1 GFAP GOLGA2 HGS HNRNPM HOMEZ HOOK2 HSF2BP HSFY1 IHO1 IKZF3 IL16 KCTD9 KLC3 KLF1 KMT2B KMT2C KPNA6 KRT15 KRT19 KRT6A KRT6B KRT6C LDOC1 LENG8 LNX2 LY96 LZTS2 MAP1LC3B MAP3K20 MAPK8IP2 MBIP MCPH1 MECP2 MESD MIF4GD MRPL53 MXI1 MYC NCK2 NONO NR0B2 NR3C1 OSGIN1 OTX2 PDPK1 PICK1 PPP1CC PPP1R15A PRKAB2 PRMT5 PSMB1 RAN RB1 RELB RINT1 RPN1 RPS6KA5 RUSC1 RXRA SAXO1 SIN3B SMARCA4 SMARCC2 SMARCD1 SRC TACC2 TAF1D TASOR2 TEKT5 TFIP11 TLE5 TNFAIP1 TNRC6A TP53 TRIM14 TRIM27 TRIM35 TSC22D4 UBQLN4 VIM XPO1 YEATS4 ZC3H11A ZDHHC17 ZNF398 ZNF688	17 interacting genes: ANKK1 CEP162 FRMD4A GTF2F2 H3C1 MLLT10 MRGBP MYCN NUMA1 PFDN1 RNF8 SMARCB1 TACC1 TACC2 TFAP2B TPM1 TRIM54
Entrez ID		6598	8089
HPRD ID		03364	03666
Ensembl ID		ENSG00000099956	ENSG00000127337
Uniprot IDs		G5E975 Q12824 Q9H836	F8W0J4 O95619
PDB IDs		5AJ1 5GJK 5L7A 5L7B 6AX5 6KAG 6KZ7 6LTH 6LTJ 6UCH	5VNA 5VNB 5XTZ 5Y8V
Enriched GO Terms of Interacting Partners?
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