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SLC6A3 and RACK1
Data Source:
HPRD
(in vitro, in vivo, two hybrid)
SLC6A3
RACK1
Description
solute carrier family 6 member 3
receptor for activated C kinase 1
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
Integral Component Of Membrane
Flotillin Complex
Axon
Neuronal Cell Body Membrane
Presynaptic Membrane
Neuron Projection
Neuronal Cell Body
Membrane Raft
Dopaminergic Synapse
Integral Component Of Postsynaptic Membrane
Integral Component Of Presynaptic Membrane
Phagocytic Cup
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Small Ribosomal Subunit
Dendrite
Midbody
Neuronal Cell Body
Perikaryon
Perinuclear Region Of Cytoplasm
Extracellular Exosome
IRE1-RACK1-PP2A Complex
Molecular Function
Protease Binding
Signaling Receptor Binding
Neurotransmitter Transmembrane Transporter Activity
Dopamine:sodium Symporter Activity
Norepinephrine:sodium Symporter Activity
Protein Binding
Drug Binding
Monoamine Transmembrane Transporter Activity
Dopamine Binding
Protein-containing Complex Binding
Metal Ion Binding
Protein N-terminus Binding
Protein Phosphatase 2A Binding
RNA Binding
Protein Kinase C Binding
Signaling Receptor Binding
Protein Binding
Ion Channel Inhibitor Activity
Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process
Enzyme Binding
Protein Phosphatase Binding
Protein Tyrosine Kinase Inhibitor Activity
Cyclin Binding
Receptor Tyrosine Kinase Binding
Signaling Adaptor Activity
SH2 Domain Binding
Protein Homodimerization Activity
Ribosome Binding
Cadherin Binding
BH3 Domain Binding
Molecular Adaptor Activity
Biological Process
Neurotransmitter Transport
Aging
Lactation
Sensory Perception Of Smell
Locomotory Behavior
Response To Iron Ion
Monoamine Transport
Dopamine Transport
Norepinephrine Transport
Adenohypophysis Development
Response To Nicotine
Sodium Ion Transmembrane Transport
Positive Regulation Of Multicellular Organism Growth
Regulation Of Dopamine Metabolic Process
Neurotransmitter Biosynthetic Process
Response To Cocaine
Dopamine Biosynthetic Process
Dopamine Catabolic Process
Response To Drug
Response To Ethanol
Dopamine Uptake Involved In Synaptic Transmission
Response To CAMP
Norepinephrine Uptake
Prepulse Inhibition
Dopamine Uptake
Hyaloid Vascular Plexus Regression
Positive Regulation Of Protein Phosphorylation
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cell Cycle
Gastrulation
Negative Regulation Of Gene Expression
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Viral Process
Protein Ubiquitination
Negative Regulation Of Translation
Negative Regulation Of Wnt Signaling Pathway
Negative Regulation Of Cell Growth
Positive Regulation Of Cell Migration
Positive Regulation Of Protein-containing Complex Assembly
Negative Regulation Of Protein Binding
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Localization
Negative Regulation Of Peptidyl-serine Phosphorylation
Positive Regulation Of Golgi To Plasma Membrane Protein Transport
Positive Regulation Of Apoptotic Process
Positive Regulation Of GTPase Activity
Negative Regulation Of Smoothened Signaling Pathway
Rhythmic Process
Negative Regulation Of Phagocytosis
Regulation Of Cell Division
Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity
Regulation Of Cell Cycle
Negative Regulation Of Protein Kinase B Signaling
Positive Regulation Of Mitochondrial Depolarization
Negative Regulation Of Protein Tyrosine Kinase Activity
Cellular Response To Glucose Stimulus
Cellular Response To Growth Factor Stimulus
Rescue Of Stalled Ribosome
Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response
Negative Regulation Of Hydrogen Peroxide-induced Neuron Death
Regulation Of Establishment Of Cell Polarity
Positive Regulation Of Ceramide Biosynthetic Process
Positive Regulation Of Gastrulation
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Dopamine clearance from the synaptic cleft
Na+/Cl- dependent neurotransmitter transporters
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
TNFR1-mediated ceramide production
Drugs
Amphetamine
Phentermine
Benzatropine
Venlafaxine
Loxapine
Methylphenidate
Meperidine
Imipramine
Duloxetine
Amoxapine
Mazindol
Procaine
Trimipramine
Modafinil
Phenmetrazine
Pseudoephedrine
Benzphetamine
Cocaine
Diethylpropion
Dopamine
Sertraline
Sibutramine
Chlorpheniramine
Diphenylpyraline
Nefazodone
Bupropion
Chloroprocaine
Escitalopram
Aripiprazole
Ephedra sinica root
MMDA
Midomafetamine
Fencamfamin
4-Methoxyamphetamine
Dextroamphetamine
Metamfetamine
Vanoxerine
Nomifensine
Altropane
Mianserin
Tesofensine
Trodusquemine
Armodafinil
Desvenlafaxine
Dexmethylphenidate
Dasotraline
Solriamfetol
Copper
Diseases
GWAS
Pancreatic cancer (
25086665
)
Interacting Genes
9 interacting genes:
DRD2
MTNR1A
NEDD4
PICK1
RACK1
SNCA
SNTA1
STX1A
TGFB1I1
112 interacting genes:
ACTN2
ADH1B
ADRB2
AGTRAP
AR
ARRDC3
ATG14
ATG5
AURKB
BCL2L11
BECN1
BIRC6
BRCA1
BYSL
CCNA1
CDKN1A
CHERP
CNOT2
CRMP1
CSF2RB
DDX19B
DNM1
DYNLL1
EED
EIF6
ELOB
EP300
EPOR
ESR1
ESS2
FBXW7
FYN
GABRB3
GATA4
GGN
GNB1
GOLM1
GPBP1
GRAP2
GRIN2B
HABP4
HIF1A
HNRNPH2
IFNAR1
IFNAR2
IGF1R
IK
IL2RB
IL4R
IL7R
INSR
ITGB1
ITGB2
ITGB5
ITGB7
JAK1
LARP4B
LRP12
MAPK6
MCPH1
MKRN2
MTNR1A
NFATC1
NR3C1
NSMAF
OLA1
PABPC1
PDE4D
PIK3R4
PLCG1
PLEC
PRKAA1
PRKAB2
PRKCA
PRKCB
PRKCD
PRKCE
PRKD1
PRPF31
PTN
PTOV1
PTPRM
RASA1
RASA3
RB1
RHOA
SAT1
SLC27A6
SLC6A3
SLC9A5
SRC
SREK1
ST7
STAT1
STAT3
SUMO4
SYT1
TARDBP
TBXA2R
TENM1
TMEM131
TNFRSF1A
TP63
TP73
TSC22D4
TUBB
TUBG1
TYK2
USP10
USP54
WDR83
ZSCAN12
Entrez ID
6531
10399
HPRD ID
00543
01503
Ensembl ID
ENSG00000142319
ENSG00000204628
Uniprot IDs
Q01959
E9KL35
P63244
PDB IDs
4AOW
4UG0
4V6X
5A2Q
5AJ0
5FLX
5LKS
5OA3
5T2C
5VYC
6EK0
6FEC
6G18
6G51
6G53
6G5H
6G5I
6IP5
6IP6
6IP8
6OLE
6OLF
6OLG
6OLI
6OLZ
6OM0
6OM7
6QZP
6XA1
6Y0G
6Y2L
6Y57
6YBS
6Z6L
6Z6M
6Z6N
6ZLW
6ZM7
6ZME
6ZMI
6ZMO
6ZMT
6ZMW
6ZN5
6ZOJ
6ZOL
6ZON
6ZP4
6ZVH
6ZVJ
7A09
7K5I
Enriched GO Terms of Interacting Partners
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