RACK1 and IL7R

Data Source:
BioGRID (unspecified method)

		RACK1	IL7R
Description		receptor for activated C kinase 1	interleukin 7 receptor
Image
GO Annotations	Cellular Component	Phagocytic Cup Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Small Ribosomal Subunit Dendrite Midbody Neuronal Cell Body Perikaryon Perinuclear Region Of Cytoplasm Extracellular Exosome IRE1-RACK1-PP2A Complex	Extracellular Region Nucleoplasm Cytosol Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Clathrin-coated Vesicle Membrane
	Molecular Function	RNA Binding Protein Kinase C Binding Signaling Receptor Binding Protein Binding Ion Channel Inhibitor Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Enzyme Binding Protein Phosphatase Binding Protein Tyrosine Kinase Inhibitor Activity Cyclin Binding Receptor Tyrosine Kinase Binding Signaling Adaptor Activity SH2 Domain Binding Protein Homodimerization Activity Ribosome Binding Cadherin Binding BH3 Domain Binding Molecular Adaptor Activity	Antigen Binding Cytokine Receptor Activity Interleukin-7 Receptor Activity Protein Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Cycle Gastrulation Negative Regulation Of Gene Expression Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Viral Process Protein Ubiquitination Negative Regulation Of Translation Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Negative Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Golgi To Plasma Membrane Protein Transport Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Negative Regulation Of Smoothened Signaling Pathway Rhythmic Process Negative Regulation Of Phagocytosis Regulation Of Cell Division Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of Cell Cycle Negative Regulation Of Protein Kinase B Signaling Positive Regulation Of Mitochondrial Depolarization Negative Regulation Of Protein Tyrosine Kinase Activity Cellular Response To Glucose Stimulus Cellular Response To Growth Factor Stimulus Rescue Of Stalled Ribosome Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Regulation Of Establishment Of Cell Polarity Positive Regulation Of Ceramide Biosynthetic Process Positive Regulation Of Gastrulation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Regulation Of DNA Recombination Cell Morphogenesis Negative Regulation Of T Cell Mediated Cytotoxicity Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Cell Size Positive Regulation Of Gene Expression T Cell Differentiation Positive Regulation Of T Cell Differentiation In Thymus Interleukin-7-mediated Signaling Pathway B Cell Proliferation Lymph Node Development Homeostasis Of Number Of Cells Defense Response To Gram-positive Bacterium Membrane Organization Negative Regulation Of T Cell Apoptotic Process Positive Regulation Of Receptor Signaling Pathway Via STAT
Pathways		Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway TNFR1-mediated ceramide production	Interleukin-7 signaling Interleukin-7 signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs		Copper
Diseases			T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 30013184 31361310) Ankylosing spondylitis ( 23749187) Asthma ( 31361310 30929738 32296059 31619474) Asthma (adult onset) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 26482879) Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576 29875488 28240269) Eczema ( 31361310) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Medication use (adrenergics, inhalants) ( 31015401) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244 21244703 24076602 19525953 21833088) Neutrophil percentage of white cells ( 32888494 27863252) Primary biliary cholangitis ( 23000144 21399635 26394269 28062665 30643196) Primary biliary cirrhosis ( 22961000) Systemic lupus erythematosus ( 33536424) Type 1 diabetes ( 25751624 17554260) Ulcerative colitis ( 21297633) White blood cell count ( 32888494)
Interacting Genes		112 interacting genes: ACTN2 ADH1B ADRB2 AGTRAP AR ARRDC3 ATG14 ATG5 AURKB BCL2L11 BECN1 BIRC6 BRCA1 BYSL CCNA1 CDKN1A CHERP CNOT2 CRMP1 CSF2RB DDX19B DNM1 DYNLL1 EED EIF6 ELOB EP300 EPOR ESR1 ESS2 FBXW7 FYN GABRB3 GATA4 GGN GNB1 GOLM1 GPBP1 GRAP2 GRIN2B HABP4 HIF1A HNRNPH2 IFNAR1 IFNAR2 IGF1R IK IL2RB IL4R IL7R INSR ITGB1 ITGB2 ITGB5 ITGB7 JAK1 LARP4B LRP12 MAPK6 MCPH1 MKRN2 MTNR1A NFATC1 NR3C1 NSMAF OLA1 PABPC1 PDE4D PIK3R4 PLCG1 PLEC PRKAA1 PRKAB2 PRKCA PRKCB PRKCD PRKCE PRKD1 PRPF31 PTN PTOV1 PTPRM RASA1 RASA3 RB1 RHOA SAT1 SLC27A6 SLC6A3 SLC9A5 SRC SREK1 ST7 STAT1 STAT3 SUMO4 SYT1 TARDBP TBXA2R TENM1 TMEM131 TNFRSF1A TP63 TP73 TSC22D4 TUBB TUBG1 TYK2 USP10 USP54 WDR83 ZSCAN12	110 interacting genes: AGTRAP ALYREF APOL3 CIRBP CPSF1 CRLF2 DDX21 DDX39B DDX3X DDX5 DHX36 DHX9 EIF2AK2 ELAVL1 EMG1 FAU FUS FYN G3BP1 H1-10 H1-2 H1-4 H2BC21 HNRNPA0 HNRNPA3 HNRNPAB HNRNPC HNRNPD HNRNPDL HNRNPH3 HNRNPL HNRNPR HNRNPU HNRNPUL1 HNRNPUL2 IL2RG IL7 ILF2 ILF3 JAK1 JAK3 KIT LYN MALL MAP4 MS4A1 NCL NONO PABPC1 PABPC4 PABPN1 PIK3R1 PTBP1 PTK2B PTMA PURA PURB QKI RACK1 RAD21 RBM3 RBMX RPL15 RPL18 RPL22 RPL29 RPL30 RPL31 RPL6 RPL7 RPL8 RPS20 RPS3 RPSA RRAGA RSL1D1 SAFB SDC4 SF1 SF3A1 SF3B1 SNRNP70 SNRPA SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG SRP14 SRP9 SRSF3 SRSF9 SSB STAT3 STAT5A STAT5B SYNCRIP TMEM120B TOE1 TOP1 TSLP U2AF1 U2AF2 YBX1 YBX3 YWHAE YWHAG ZNF787
Entrez ID		10399	3575
HPRD ID		01503	00893
Ensembl ID		ENSG00000204628	ENSG00000168685
Uniprot IDs		E9KL35 P63244	P16871
PDB IDs		4AOW 4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6EK0 6FEC 6G18 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBS 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOL 6ZON 6ZP4 6ZVH 6ZVJ 7A09 7K5I	3DI2 3DI3 3UP1 5J11 6P50 6P67
Enriched GO Terms of Interacting Partners?
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