WNK4 and NEDD4L

Data Source:
BioGRID (enzymatic study)

		WNK4	NEDD4L
Description		WNK lysine deficient protein kinase 4	NEDD4 like E3 ubiquitin protein ligase
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GO Annotations	Cellular Component	Cytoplasm Cytosol Bicellular Tight Junction Membrane	Nucleoplasm Cytoplasm Multivesicular Body Golgi Apparatus Cytosol Plasma Membrane Extracellular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Chloride Channel Inhibitor Activity Potassium Channel Inhibitor Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity	Ubiquitin-protein Transferase Activity Protein Binding Potassium Channel Regulator Activity Sodium Channel Regulator Activity Potassium Channel Inhibitor Activity Sodium Channel Inhibitor Activity Ion Channel Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Phosphorylation Ion Transport Chloride Transport Protein Localization Negative Regulation Of Sodium Ion Transport Intracellular Signal Transduction Regulation Of Cellular Process Ion Homeostasis Renal Sodium Ion Absorption Distal Tubule Morphogenesis Negative Regulation Of Pancreatic Juice Secretion Positive Regulation Of Potassium Ion Import Across Plasma Membrane Positive Regulation Of Sodium Ion Transmembrane Transporter Activity	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Regulation Of Membrane Depolarization Ubiquitin-dependent Protein Catabolic Process Sodium Ion Transport Cellular Sodium Ion Homeostasis Excretion Response To Metal Ion Protein Ubiquitination Viral Life Cycle Water Homeostasis Cell Differentiation Regulation Of Protein Stability Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Regulation Of Protein Catabolic Process Regulation Of Membrane Potential Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Endocytosis Regulation Of Dendrite Morphogenesis Regulation Of Membrane Repolarization Protein K48-linked Ubiquitination Ventricular Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Dendrite Extension Negative Regulation Of Protein Localization To Cell Surface Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Caveolin-mediated Endocytosis
Pathways		Stimuli-sensing channels	Budding and maturation of HIV virion Downregulation of TGF-beta receptor signaling Downregulation of SMAD2/3:SMAD4 transcriptional activity Stimuli-sensing channels Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)
GWAS			Amyotrophic lateral sclerosis (sporadic) ( 24529757) Childhood body mass index ( 33045005) Diastolic blood pressure ( 30224653) Diisocyanate-induced asthma ( 25918132) Gamma glutamyl transferase levels ( 29403010) Insomnia (caffeine-induced) ( 22754043) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Manganese levels ( 26025379) Response to amphetamines ( 22952603)
Interacting Genes		11 interacting genes: AKT1 BCL6 CLDN1 CLDN2 CLDN3 CLDN4 KLHL2 KLHL3 NEDD4L SLC12A3 STK39	133 interacting genes: AATF ABL1 ABL2 ACVR1B ACY3 ADAP2 AICDA AKT3 AMOT APEX2 ARHGDIA ARRDC3 AURKC BBX BMPR1A C7orf50 CACNB1 CAMK1D CDC34 CDK3 CDK5 CLIC2 CUEDC1 CYBRD1 CYP26B1 DAPK3 DAZAP2 DDX54 DECR2 DMTN DYRK3 EFEMP2 FGF12 FKBP3 GORAB GRIA1 H1-0 HAX1 IFRD2 IKBKB KCNAB1 KCNAB2 KCNAB3 KCNB1 KIF3B KIFC3 LAPTM5 MAGEB1 MAP2 MAP3K2 MAP3K20 MAP3K3 MAP3K5 MAPKAPK3 MARK2 MERTK MINK1 MOB3A MRPL19 NDFIP2 NEAT1 NHP2 NR3C1 NSRP1 NTRK1 NUDT16L1 PBX1 PIK3CA PIP4P2 PRKX PRR16 PRRG1 PSMD4 PYM1 RANBP10 RASL10B RASL11B RHOB RNF11 RNF7 ROBO3 RPL30 RPS6KB2 SCAMP3 SCD SCN5A SCNN1A SCNN1B SCNN1G SENP2 SERPINF1 SGK1 SGK2 SIVA1 SLC7A7 SMAD2 SMAD3 SMAD7 SNCA SPAG8 SRMS STAC STK40 TAF1B TARBP2 TBC1D7 TCEAL2 TGFB1I1 TMA16 TRIM41 UBAC1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2J2 UBE2K UBE2L3 UBE2L6 UBE2N ULK1 VDAC2 WBP2 WNK4 YWHAG YWHAZ YY1 ZADH2 ZC3HAV1L ZDHHC3
Entrez ID		65266	23327
HPRD ID		03505	05903
Ensembl ID		ENSG00000126562	ENSG00000049759
Uniprot IDs		Q96J92	A0A024R281 A0A024R2A4 B7Z2P9 B7Z6K0 Q96PU5
PDB IDs		2V3S 4CH9 4CHB	2LAJ 2LB2 2LTY 2MPT 2NSQ 2ONI 3JVZ 3JW0 5HPK
Enriched GO Terms of Interacting Partners?
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