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NEDD4L and SCNN1B
Data Source:
HPRD
(in vivo, in vitro)
NEDD4L
SCNN1B
Description
NEDD4 like E3 ubiquitin protein ligase
sodium channel epithelial 1 subunit beta
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Multivesicular Body
Golgi Apparatus
Cytosol
Plasma Membrane
Extracellular Exosome
Plasma Membrane
Integral Component Of Plasma Membrane
External Side Of Plasma Membrane
Apical Plasma Membrane
Cytoplasmic Vesicle Membrane
Sodium Channel Complex
Extracellular Exosome
Plasma Membrane Protein Complex
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Potassium Channel Regulator Activity
Sodium Channel Regulator Activity
Potassium Channel Inhibitor Activity
Sodium Channel Inhibitor Activity
Ion Channel Binding
Ubiquitin Protein Ligase Activity
Protein Binding
Ligand-gated Sodium Channel Activity
WW Domain Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Protein Polyubiquitination
Regulation Of Membrane Depolarization
Ubiquitin-dependent Protein Catabolic Process
Sodium Ion Transport
Cellular Sodium Ion Homeostasis
Excretion
Response To Metal Ion
Protein Ubiquitination
Viral Life Cycle
Water Homeostasis
Cell Differentiation
Regulation Of Protein Stability
Ion Transmembrane Transport
Regulation Of Ion Transmembrane Transport
Regulation Of Protein Catabolic Process
Regulation Of Membrane Potential
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Endocytosis
Regulation Of Dendrite Morphogenesis
Regulation Of Membrane Repolarization
Protein K48-linked Ubiquitination
Ventricular Cardiac Muscle Cell Action Potential
Regulation Of Potassium Ion Transmembrane Transporter Activity
Negative Regulation Of Potassium Ion Transmembrane Transporter Activity
Negative Regulation Of Potassium Ion Transmembrane Transport
Negative Regulation Of Sodium Ion Transmembrane Transport
Positive Regulation Of Dendrite Extension
Negative Regulation Of Protein Localization To Cell Surface
Negative Regulation Of Sodium Ion Transmembrane Transporter Activity
Positive Regulation Of Caveolin-mediated Endocytosis
Sodium Ion Transport
Excretion
Gene Expression
Artery Smooth Muscle Contraction
Ion Transmembrane Transport
Sodium Ion Transmembrane Transport
Epithelial Fluid Transport
Response To Drug
Multicellular Organismal Water Homeostasis
Sensory Perception Of Taste
Sodium Ion Homeostasis
Cellular Response To Aldosterone
Pathways
Budding and maturation of HIV virion
Downregulation of TGF-beta receptor signaling
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Stimuli-sensing channels
Antigen processing: Ubiquitination & Proteasome degradation
Stimuli-sensing channels
Drugs
Triamterene
Amiloride
Diseases
Liddle syndrome
Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)
Bronchiectasis with or without elevated sweat chloride
GWAS
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Childhood body mass index (
33045005
)
Diastolic blood pressure (
30224653
)
Diisocyanate-induced asthma (
25918132
)
Gamma glutamyl transferase levels (
29403010
)
Insomnia (caffeine-induced) (
22754043
)
Liver enzyme levels (gamma-glutamyl transferase) (
22001757
)
Manganese levels (
26025379
)
Response to amphetamines (
22952603
)
Kidney stones (
31729369
)
Interacting Genes
133 interacting genes:
AATF
ABL1
ABL2
ACVR1B
ACY3
ADAP2
AICDA
AKT3
AMOT
APEX2
ARHGDIA
ARRDC3
AURKC
BBX
BMPR1A
C7orf50
CACNB1
CAMK1D
CDC34
CDK3
CDK5
CLIC2
CUEDC1
CYBRD1
CYP26B1
DAPK3
DAZAP2
DDX54
DECR2
DMTN
DYRK3
EFEMP2
FGF12
FKBP3
GORAB
GRIA1
H1-0
HAX1
IFRD2
IKBKB
KCNAB1
KCNAB2
KCNAB3
KCNB1
KIF3B
KIFC3
LAPTM5
MAGEB1
MAP2
MAP3K2
MAP3K20
MAP3K3
MAP3K5
MAPKAPK3
MARK2
MERTK
MINK1
MOB3A
MRPL19
NDFIP2
NEAT1
NHP2
NR3C1
NSRP1
NTRK1
NUDT16L1
PBX1
PIK3CA
PIP4P2
PRKX
PRR16
PRRG1
PSMD4
PYM1
RANBP10
RASL10B
RASL11B
RHOB
RNF11
RNF7
ROBO3
RPL30
RPS6KB2
SCAMP3
SCD
SCN5A
SCNN1A
SCNN1B
SCNN1G
SENP2
SERPINF1
SGK1
SGK2
SIVA1
SLC7A7
SMAD2
SMAD3
SMAD7
SNCA
SPAG8
SRMS
STAC
STK40
TAF1B
TARBP2
TBC1D7
TCEAL2
TGFB1I1
TMA16
TRIM41
UBAC1
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2J2
UBE2K
UBE2L3
UBE2L6
UBE2N
ULK1
VDAC2
WBP2
WNK4
YWHAG
YWHAZ
YY1
ZADH2
ZC3HAV1L
ZDHHC3
14 interacting genes:
ANK3
CNTN1
COMMD10
EPN1
HECW1
ITCH
NEDD4
NEDD4L
NFASC
SCNN1A
SCNN1D
SCNN1G
STX1A
WWP2
Entrez ID
23327
6338
HPRD ID
05903
02861
Ensembl ID
ENSG00000049759
ENSG00000168447
Uniprot IDs
A0A024R281
A0A024R2A4
B7Z2P9
B7Z6K0
Q96PU5
B2R812
P51168
PDB IDs
2LAJ
2LB2
2LTY
2MPT
2NSQ
2ONI
3JVZ
3JW0
5HPK
6BQN
6WTH
Enriched GO Terms of Interacting Partners
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