WNK4 and CLDN3

Data Source:
HPRD (in vivo)

		WNK4	CLDN3
Description		WNK lysine deficient protein kinase 4	claudin 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Bicellular Tight Junction Membrane	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Bicellular Tight Junction Integral Component Of Membrane Apicolateral Plasma Membrane Lateral Plasma Membrane Protein-containing Complex Apical Junction Complex Tight Junction
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Chloride Channel Inhibitor Activity Potassium Channel Inhibitor Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity	Transmembrane Signaling Receptor Activity Structural Molecule Activity Protein Binding Identical Protein Binding
	Biological Process	Protein Phosphorylation Ion Transport Chloride Transport Protein Localization Negative Regulation Of Sodium Ion Transport Intracellular Signal Transduction Regulation Of Cellular Process Ion Homeostasis Renal Sodium Ion Absorption Distal Tubule Morphogenesis Negative Regulation Of Pancreatic Juice Secretion Positive Regulation Of Potassium Ion Import Across Plasma Membrane Positive Regulation Of Sodium Ion Transmembrane Transporter Activity	Response To Hypoxia Positive Regulation Of Protein Phosphorylation Epithelial Cell Morphogenesis Cell Adhesion Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Establishment Of Endothelial Blood-brain Barrier Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Regulation Of Cell Morphogenesis Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Actin Cytoskeleton Reorganization Cell Junction Maintenance Maintenance Of Blood-brain Barrier Response To Ethanol Negative Regulation Of Wound Healing Bicellular Tight Junction Assembly Positive Regulation Of Wound Healing Regulation Of Membrane Permeability Regulation Of Transepithelial Transport Positive Regulation Of Cell Junction Assembly Positive Regulation Of Bicellular Tight Junction Assembly Positive Regulation Of Metallopeptidase Activity
Pathways		Stimuli-sensing channels	Tight junction interactions
Drugs
Diseases		Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)
GWAS			Mean platelet volume ( 27863252) Platelet distribution width ( 27863252)
Interacting Genes		11 interacting genes: AKT1 BCL6 CLDN1 CLDN2 CLDN3 CLDN4 KLHL2 KLHL3 NEDD4L SLC12A3 STK39	7 interacting genes: APP CLDN1 CLDN5 POM121 PRKACA TJP1 WNK4
Entrez ID		65266	1365
HPRD ID		03505	04219
Ensembl ID		ENSG00000126562	ENSG00000165215
Uniprot IDs		Q96J92	O15551 Q75L79
PDB IDs		2V3S 4CH9 4CHB
Enriched GO Terms of Interacting Partners?
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