SKIL and TDG

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SKIL	TDG
Description		SKI like proto-oncogene	thymine DNA glycosylase
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GO Annotations	Cellular Component	Acrosomal Vesicle Nucleus Nucleoplasm Transcription Regulator Complex Protein-containing Complex	Nucleus Nucleoplasm Plasma Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding SMAD Binding	Magnesium Ion Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Uracil DNA N-glycosylase Activity Protein Binding ATP Binding Transcription Factor Binding Pyrimidine-specific Mismatch Base Pair DNA N-glycosylase Activity DNA N-glycosylase Activity Protein Domain Specific Binding Mismatched DNA Binding Sodium Ion Binding Chloride Ion Binding SUMO Binding Protein Homodimerization Activity Protein Self-association G/U Mismatch-specific Uracil-DNA Glycosylase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Blastocyst Formation Lymphocyte Homeostasis Cell Cycle Arrest Transforming Growth Factor Beta Receptor Signaling Pathway Spermatogenesis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Response To Cytokine Negative Regulation Of Cell Differentiation Positive Regulation Of Axonogenesis Lens Fiber Cell Differentiation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage	Negative Regulation Of Transcription By RNA Polymerase II Base-excision Repair Base-excision Repair, AP Site Formation Mismatch Repair Chromatin Organization Oxidative DNA Demethylation Regulation Of Gene Expression, Epigenetic Depyrimidination Regulation Of Embryonic Development DNA Demethylation Regulation Of DNA N-glycosylase Activity
Pathways		Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Displacement of DNA glycosylase by APEX1 SUMOylation of DNA damage response and repair proteins TET1,2,3 and TDG demethylate DNA
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163) Glomerular filtration rate (creatinine) ( 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Prostate cancer ( 21743467)	Glucagon levels in response to oral glucose tolerance test (fasting) ( 29093273) Metabolite levels ( 23823483)
Interacting Genes		96 interacting genes: ASCC3 CAMSAP1 CBX4 CDC16 CDC27 CHD3 CHPF COL4A2 CPNE1 CPNE2 CPNE4 CXXC5 DEUP1 DHX30 DRG1 EEF1G EIF4G2 ESR1 FAF1 FBLN1 FN1 FZR1 GAS8 GLUL GOLGB1 HEY1 HEYL HIPK1 HIPK3 HNRNPLL IL36RN KRT81 LRP1 MACF1 MORC4 MVP MYG1 NCOR1 NCOR2 NEFL NID1 NID2 NXF3 OIP5 PAPPA PIAS1 PIAS3 PIAS4 PLCD3 PPL PSG3 PSMC2 PTPRF PYCR2 RNF4 RPS27 SASH1 SETDB1 SKI SMAD1 SMAD2 SMAD3 SMAD4 SMUG1 SMURF2 SNRNP70 SNX17 SPARCL1 SRP72 STK16 SVEP1 TDG TDP2 TFPI2 THAP5 THSD7A TLE5 TPM2 TRAK1 TRIM62 TRIM69 TSKU TTF2 UBE2I UIMC1 USP25 VPS28 XPA XRCC6 ZBTB3 ZBTB6 ZMYM2 ZMYM5 ZNF106 ZNF200 ZZEF1	36 interacting genes: AR CREBBP CRK DDX39B DNMT3B DTL EP300 EPM2A ESR1 HUS1 IKZF1 JUN JUNB MX1 NKX2-1 NR3C1 PCNA PGR PML RAD1 RAD23B RAD9A RXRA SERBP1 SIRT6 SKIL SMAD4 SNIP1 STAT3 SUMO1 SUMO2 SUMO3 THRA UBE2I VDR XPC
Entrez ID		6498	6996
HPRD ID		01319	03251
Ensembl ID		ENSG00000136603	ENSG00000139372
Uniprot IDs		P12757	B4DI29 B4E127 Q13569
PDB IDs		3EQ5 5C4V	1WYW 2D07 2RBA 3UFJ 3UO7 3UOB 4FNC 4JGC 4XEG 4Z3A 4Z47 4Z7B 4Z7Z 5CYS 5FF8 5HF7 5JXY 5T2W 6U15 6U16 6U17
Enriched GO Terms of Interacting Partners?
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