TDG and SIRT6

Data Source:
BioGRID (two hybrid)

		TDG	SIRT6
Description		thymine DNA glycosylase	sirtuin 6
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Plasma Membrane	Nucleus Nucleoplasm Nucleolus Cytoplasm Chromosome, Subtelomeric Region
	Molecular Function	Magnesium Ion Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Uracil DNA N-glycosylase Activity Protein Binding ATP Binding Transcription Factor Binding Pyrimidine-specific Mismatch Base Pair DNA N-glycosylase Activity DNA N-glycosylase Activity Protein Domain Specific Binding Mismatched DNA Binding Sodium Ion Binding Chloride Ion Binding SUMO Binding Protein Homodimerization Activity Protein Self-association G/U Mismatch-specific Uracil-DNA Glycosylase Activity	Transcription Corepressor Activity NAD+ ADP-ribosyltransferase Activity NAD(P)+-protein-arginine ADP-ribosyltransferase Activity Histone Deacetylase Activity Protein Binding Zinc Ion Binding NAD-dependent Histone Deacetylase Activity Deacetylase Activity NAD-dependent Protein Deacetylase Activity NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) NAD+ Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Base-excision Repair Base-excision Repair, AP Site Formation Mismatch Repair Chromatin Organization Oxidative DNA Demethylation Regulation Of Gene Expression, Epigenetic Depyrimidination Regulation Of Embryonic Development DNA Demethylation Regulation Of DNA N-glycosylase Activity	Negative Regulation Of Transcription By RNA Polymerase II Post-embryonic Cardiac Muscle Cell Growth Involved In Heart Morphogenesis Protein ADP-ribosylation Protein Deacetylation Regulation Of Double-strand Break Repair Via Homologous Recombination Response To Nutrient Levels Positive Regulation Of Chromatin Silencing At Telomere Positive Regulation Of Telomere Maintenance Histone H3-K9 Modification Histone H3 Deacetylation Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Transcription Factor Catabolic Process Positive Regulation Of Chondrocyte Proliferation Positive Regulation Of Subtelomeric Heterochromatin Assembly Positive Regulation Of Blood Vessel Branching Positive Regulation Of Vascular Endothelial Cell Proliferation Histone H3-K9 Deacetylation
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Displacement of DNA glycosylase by APEX1 SUMOylation of DNA damage response and repair proteins TET1,2,3 and TDG demethylate DNA	Pre-NOTCH Transcription and Translation Processing of DNA double-strand break ends
Drugs
Diseases
GWAS		Glucagon levels in response to oral glucose tolerance test (fasting) ( 29093273) Metabolite levels ( 23823483)
Interacting Genes		36 interacting genes: AR CREBBP CRK DDX39B DNMT3B DTL EP300 EPM2A ESR1 HUS1 IKZF1 JUN JUNB MX1 NKX2-1 NR3C1 PCNA PGR PML RAD1 RAD23B RAD9A RXRA SERBP1 SIRT6 SKIL SMAD4 SNIP1 STAT3 SUMO1 SUMO2 SUMO3 THRA UBE2I VDR XPC	17 interacting genes: AKT1 CCNDBP1 CDKN1B CHD3 ELF5 FAF1 HUS1 MUTYH RAD1 SKP2 STUB1 TDG TSPYL2 UBE2D1 UBE3A USP10 VIM
Entrez ID		6996	51548
HPRD ID		03251	12093
Ensembl ID		ENSG00000139372	ENSG00000077463
Uniprot IDs		B4DI29 B4E127 Q13569	B4DDV3 M0QXA0 M0R1N9 Q8N6T7
PDB IDs		1WYW 2D07 2RBA 3UFJ 3UO7 3UOB 4FNC 4JGC 4XEG 4Z3A 4Z47 4Z7B 4Z7Z 5CYS 5FF8 5HF7 5JXY 5T2W 6U15 6U16 6U17	3K35 3PKI 3PKJ 3ZG6 5MF6 5MFP 5MFZ 5MGN 5X16 5Y2F 6HOY 6QCD 6QCE 6QCH 6QCJ 6XUY 6XV1 6XV6 6XVG
Enriched GO Terms of Interacting Partners?
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