SFRP4 and NARF

Data Source:
BioGRID (two hybrid)

		SFRP4	NARF
Description		secreted frizzled related protein 4	nuclear prelamin A recognition factor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Cell Surface	Lamin Filament Nuclear Lamina Nucleoplasm Nucleolus Nuclear Lumen
	Molecular Function	Protein Binding Wnt-protein Binding	Lamin Binding
	Biological Process	Positive Regulation Of Receptor Internalization Negative Regulation Of Cell Population Proliferation Response To Hormone Positive Regulation Of Gene Expression Cell Differentiation Negative Regulation Of Wnt Signaling Pathway Regulation Of BMP Signaling Pathway Non-canonical Wnt Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Epidermal Cell Differentiation Phosphate Ion Homeostasis Canonical Wnt Signaling Pathway Bone Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Keratinocyte Apoptotic Process Negative Regulation Of Non-canonical Wnt Signaling Pathway Negative Regulation Of Sodium-dependent Phosphate Transport
Pathways
Drugs		Cyclothiazide Perindopril
Diseases
GWAS		Blood protein levels ( 30072576) Dupuytren's disease ( 28886342 21732829) Heel bone mineral density ( 30598549 28869591)	Change in neurofilament light levels ( 31295725) Glucocorticoid-induced osteonecrosis ( 26265699) Lung function ( 31902109)
Interacting Genes		21 interacting genes: AP2M1 AQP6 AURKA BMPR1A BUB1 CDKN2A CKMT1B CTNNA1 DLC1 ERBB2 HSD17B11 MCC NARF NRAS PDGFRL PFKM PIK3CA PMS2 PTPN12 PTPRJ SMAD4	3 interacting genes: APP LMNA SFRP4
Entrez ID		6424	26502
HPRD ID		07357	05637
Ensembl ID		ENSG00000106483	ENSG00000141562
Uniprot IDs		Q6FHJ7	Q9UHQ1
PDB IDs
Enriched GO Terms of Interacting Partners?
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