NARF and SFRP4

Data Source:
BioGRID (two hybrid)

		NARF	SFRP4
Description		nuclear prelamin A recognition factor	secreted frizzled related protein 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Lamin Filament Nuclear Lamina Nucleoplasm Nucleolus Nuclear Lumen	Extracellular Space Nucleus Cytoplasm Cell Surface
	Molecular Function	Lamin Binding	Protein Binding Wnt-protein Binding
	Biological Process		Positive Regulation Of Receptor Internalization Negative Regulation Of Cell Population Proliferation Response To Hormone Positive Regulation Of Gene Expression Cell Differentiation Negative Regulation Of Wnt Signaling Pathway Regulation Of BMP Signaling Pathway Non-canonical Wnt Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Epidermal Cell Differentiation Phosphate Ion Homeostasis Canonical Wnt Signaling Pathway Bone Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Keratinocyte Apoptotic Process Negative Regulation Of Non-canonical Wnt Signaling Pathway Negative Regulation Of Sodium-dependent Phosphate Transport
Pathways
Drugs			Cyclothiazide Perindopril
Diseases
GWAS		Change in neurofilament light levels ( 31295725) Glucocorticoid-induced osteonecrosis ( 26265699) Lung function ( 31902109)	Blood protein levels ( 30072576) Dupuytren's disease ( 28886342 21732829) Heel bone mineral density ( 30598549 28869591)
Interacting Genes		3 interacting genes: APP LMNA SFRP4	21 interacting genes: AP2M1 AQP6 AURKA BMPR1A BUB1 CDKN2A CKMT1B CTNNA1 DLC1 ERBB2 HSD17B11 MCC NARF NRAS PDGFRL PFKM PIK3CA PMS2 PTPN12 PTPRJ SMAD4
Entrez ID		26502	6424
HPRD ID		05637	07357
Ensembl ID		ENSG00000141562	ENSG00000106483
Uniprot IDs		Q9UHQ1	Q6FHJ7
PDB IDs
Enriched GO Terms of Interacting Partners?
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