SFRP4 and CKMT1B

Data Source:
BioGRID (two hybrid)

		SFRP4	CKMT1B
Description		secreted frizzled related protein 4	creatine kinase, mitochondrial 1B
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Cell Surface	Mitochondrion Mitochondrial Inner Membrane
	Molecular Function	Protein Binding Wnt-protein Binding	Creatine Kinase Activity Protein Binding ATP Binding Kinase Activity
	Biological Process	Positive Regulation Of Receptor Internalization Negative Regulation Of Cell Population Proliferation Response To Hormone Positive Regulation Of Gene Expression Cell Differentiation Negative Regulation Of Wnt Signaling Pathway Regulation Of BMP Signaling Pathway Non-canonical Wnt Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Epidermal Cell Differentiation Phosphate Ion Homeostasis Canonical Wnt Signaling Pathway Bone Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Keratinocyte Apoptotic Process Negative Regulation Of Non-canonical Wnt Signaling Pathway Negative Regulation Of Sodium-dependent Phosphate Transport	Creatine Metabolic Process Phosphorylation Phosphocreatine Biosynthetic Process
Pathways			Creatine metabolism
Drugs		Cyclothiazide Perindopril	Creatine Phosphocreatine
Diseases
GWAS		Blood protein levels ( 30072576) Dupuytren's disease ( 28886342 21732829) Heel bone mineral density ( 30598549 28869591)
Interacting Genes		21 interacting genes: AP2M1 AQP6 AURKA BMPR1A BUB1 CDKN2A CKMT1B CTNNA1 DLC1 ERBB2 HSD17B11 MCC NARF NRAS PDGFRL PFKM PIK3CA PMS2 PTPN12 PTPRJ SMAD4	13 interacting genes: ASB9 CALM1 CKM CTNNA3 HPCA NUTF2 OCM PPP1R16A PSMC3 RXRG SFRP4 SLC25A5 VDAC1
Entrez ID		6424	1159
HPRD ID		07357	00424
Ensembl ID		ENSG00000106483	ENSG00000237289
Uniprot IDs		Q6FHJ7	P12532
PDB IDs			1QK1
Enriched GO Terms of Interacting Partners?
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