CKMT1B and SFRP4

Data Source:
BioGRID (two hybrid)

		CKMT1B	SFRP4
Description		creatine kinase, mitochondrial 1B	secreted frizzled related protein 4
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane	Extracellular Space Nucleus Cytoplasm Cell Surface
	Molecular Function	Creatine Kinase Activity Protein Binding ATP Binding Kinase Activity	Protein Binding Wnt-protein Binding
	Biological Process	Creatine Metabolic Process Phosphorylation Phosphocreatine Biosynthetic Process	Positive Regulation Of Receptor Internalization Negative Regulation Of Cell Population Proliferation Response To Hormone Positive Regulation Of Gene Expression Cell Differentiation Negative Regulation Of Wnt Signaling Pathway Regulation Of BMP Signaling Pathway Non-canonical Wnt Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Epidermal Cell Differentiation Phosphate Ion Homeostasis Canonical Wnt Signaling Pathway Bone Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Keratinocyte Apoptotic Process Negative Regulation Of Non-canonical Wnt Signaling Pathway Negative Regulation Of Sodium-dependent Phosphate Transport
Pathways		Creatine metabolism
Drugs		Creatine Phosphocreatine	Cyclothiazide Perindopril
Diseases
GWAS			Blood protein levels ( 30072576) Dupuytren's disease ( 28886342 21732829) Heel bone mineral density ( 30598549 28869591)
Interacting Genes		13 interacting genes: ASB9 CALM1 CKM CTNNA3 HPCA NUTF2 OCM PPP1R16A PSMC3 RXRG SFRP4 SLC25A5 VDAC1	21 interacting genes: AP2M1 AQP6 AURKA BMPR1A BUB1 CDKN2A CKMT1B CTNNA1 DLC1 ERBB2 HSD17B11 MCC NARF NRAS PDGFRL PFKM PIK3CA PMS2 PTPN12 PTPRJ SMAD4
Entrez ID		1159	6424
HPRD ID		00424	07357
Ensembl ID		ENSG00000237289	ENSG00000106483
Uniprot IDs		P12532	Q6FHJ7
PDB IDs		1QK1
Enriched GO Terms of Interacting Partners?
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