Description |
mitogen-activated protein kinase kinase 4 |
mitogen-activated protein kinase 10 |
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Cellular Component |
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Molecular Function |
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Biological Process |
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Pathways |
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Drugs |
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- Minocycline
- Pyrazolanthrone
- Cyclohexyl-{4-[5-(3,4-Dichlorophenyl)-2-Piperidin-4-Yl-3-Propyl-3h-Imidazol-4-Yl]-Pyrimidin-2-Yl}Amine
- Cyclopropyl-{4-[5-(3,4-Dichlorophenyl)-2-[(1-Methyl)-Piperidin]-4-Yl-3-Propyl-3h-Imidazol-4-Yl]-Pyrimidin-2-Yl}Amine
- 9-(4-Hydroxyphenyl)-2,7-Phenanthroline
- Phosphoaminophosphonic Acid-Adenylate Ester
- N-(tert-butyl)-4-[5-(pyridin-2-ylamino)quinolin-3-yl]benzenesulfonamide
- N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDE
- N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-2-fluorobenzamide
- 4-{[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino}-N-ethylpiperidine-1-carboxamide
- (3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-4-[(E)-2-phenylethenyl]-1H-indole-2,3-dione 3-oxime
- (3E)-5-fluoro-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-1H-indole-2,3-dione 3-oxime
- (3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-4-phenyl-1H-indole-2,3-dione 3-oxime
- 5-bromo-N-(3-chloro-2-(4-(prop-2-ynyl)piperazin-1-yl)phenyl)furan-2-carboxamide
- N-cyclohexyl-4-imidazo[1,2-a]pyridin-3-yl-N-methylpyrimidin-2-amine
- N-{2'-[(4-FLUOROPHENYL)AMINO]-4,4'-BIPYRIDIN-2-YL}-4-METHOXYCYCLOHEXANECARBOXAMIDE
- 2-{4-[(4-imidazo[1,2-a]pyridin-3-ylpyrimidin-2-yl)amino]piperidin-1-yl}-N-methylacetamide
- 1-(3-bromophenyl)-7-chloro-6-methoxy-3,4-dihydroisoquinoline
- Fostamatinib
- Halicin
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Diseases |
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GWAS |
- Asthma ( 32296059)
- Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
- Estimated glomerular filtration rate ( 31152163)
- Response to amphetamines ( 22952603)
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- Cleft lip with or without cleft palate x maternal periconceptional smoking interaction (parent of origin effect) ( 31372216)
- Cobalt levels ( 26025379)
- Diisocyanate-induced asthma ( 25918132)
- Gait speed in old age ( 28077804)
- Liver enzyme levels (alanine transaminase) ( 22001757)
- Multiple sclerosis ( 31604244)
- Peripheral artery disease ( 25009551)
- Response to cytidine analogues (gemcitabine) ( 24483146)
- Triglyceride levels ( 32203549 32154731)
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Interacting Genes |
43 interacting genes:
AKT1
ALDOB
APP
ARRB1
ARRB2
CFLAR
CYLC2
DUSP22
EFNA4
FBP2
FLNA
FLNC
GEMIN5
ITCH
JUN
LRRK2
MAP2K6
MAP3K1
MAP3K10
MAP3K11
MAP3K12
MAP3K14
MAP3K2
MAP3K20
MAP3K3
MAP3K4
MAP3K5
MAP3K7
MAP3K8
MAP4K2
MAPK1
MAPK10
MAPK12
MAPK14
MAPK8
MAPK8IP3
MAPK9
NBR1
RBBP8
SPAG9
STX17
TRIB1
UBC
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38 interacting genes:
APP
ARRB1
ARRB2
ATF2
BCL2L11
CDK5
CDKN1B
CDKN2A
CDKN2C
CEP290
CREBBP
DUSP10
DUSP16
DUSP9
ELK1
FBXO7
GTF3C1
HAX1
HDAC9
HNRNPK
HRAS
JUN
KIF26A
LDHA
MAP2K4
MAPK8IP2
MAPK8IP3
MAPKBP1
MAPT
MCL1
PKMYT1
PLIN2
RELA
SH3BP5
STMN2
TNIP1
TP53
UNC119
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Entrez ID |
6416 |
5602 |
HPRD ID |
03213 |
04207 |
Ensembl ID |
ENSG00000065559
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ENSG00000109339
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Uniprot IDs |
P45985
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A0A1P0B7D2
A0A286YEQ7
A0A286YES0
A0A286YF02
A0A286YF97
A0A286YFD7
A0A286YFN2
D6RCB1
D6RJF9
F8W9R5
I6L9F3
P53779
Q499Y8
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PDB IDs |
3ALN
3ALO
3VUT
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1JNK
1PMN
1PMU
1PMV
2B1P
2EXC
2O0U
2O2U
2OK1
2P33
2R9S
2WAJ
2ZDT
2ZDU
3CGF
3CGO
3DA6
3FI2
3FI3
3FV8
3G90
3G9L
3G9N
3KVX
3OXI
3OY1
3PTG
3RTP
3TTI
3TTJ
3V6R
3V6S
4H36
4H39
4H3B
4KKE
4KKG
4KKH
4U79
4W4V
4W4W
4W4X
4W4Y
4WHZ
4X21
4Y46
4Y5H
4Z9L
6EKD
6EMH
6EQ9
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Enriched GO Terms of Interacting Partners? |
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Tagcloud ? |
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Tagcloud (Difference) ? |
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Tagcloud (Intersection) ? |
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