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MAP2K4 and MAP3K10
Data Source:
HPRD
(in vitro)
MAP2K4
MAP3K10
Description
mitogen-activated protein kinase kinase 4
mitogen-activated protein kinase kinase kinase 10
Image
GO Annotations
Cellular Component
Nucleus
Cytosol
Axon
Dendrite Cytoplasm
Perikaryon
Cytoplasm
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Activity
Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
JUN Kinase Kinase Activity
Mitogen-activated Protein Kinase Kinase Kinase Binding
Transcription Corepressor Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
JUN Kinase Kinase Kinase Activity
ATP Binding
Protein Homodimerization Activity
BHLH Transcription Factor Binding
Biological Process
Activation Of MAPK Activity
Apoptotic Process
Signal Transduction
JNK Cascade
Activation Of JUN Kinase Activity
Response To Wounding
Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Smooth Muscle Cell Apoptotic Process
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of DNA Replication
Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Cell Growth Involved In Cardiac Muscle Cell Development
Cellular Response To Mechanical Stimulus
Cellular Response To Sorbitol
Negative Regulation Of Motor Neuron Apoptotic Process
Apoptotic Process
Signal Transduction
Smoothened Signaling Pathway
JNK Cascade
Activation Of JNKK Activity
Activation Of JUN Kinase Activity
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Positive Regulation Of Apoptotic Process
Negative Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of JUN Kinase Activity
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of JNK Cascade
Protein Autophosphorylation
Pathways
Oxidative Stress Induced Senescence
Oxidative Stress Induced Senescence
FCERI mediated MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Uptake and function of anthrax toxins
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Drugs
Fostamatinib
Diseases
GWAS
Asthma (
32296059
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Estimated glomerular filtration rate (
31152163
)
Response to amphetamines (
22952603
)
Birth weight (
31043758
)
Resting heart rate (
27798624
)
Interacting Genes
43 interacting genes:
AKT1
ALDOB
APP
ARRB1
ARRB2
CFLAR
CYLC2
DUSP22
EFNA4
FBP2
FLNA
FLNC
GEMIN5
ITCH
JUN
LRRK2
MAP2K6
MAP3K1
MAP3K10
MAP3K11
MAP3K12
MAP3K14
MAP3K2
MAP3K20
MAP3K3
MAP3K4
MAP3K5
MAP3K7
MAP3K8
MAP4K2
MAPK1
MAPK10
MAPK12
MAPK14
MAPK8
MAPK8IP3
MAPK9
NBR1
RBBP8
SPAG9
STX17
TRIB1
UBC
31 interacting genes:
ABL2
CDC42
CEACAM1
CLTC
CNKSR1
COPS2
DLG4
DNM1
DNM1L
GARS1
HGS
HTT
KIF17
KIF3A
KIF3B
KIFAP3
MAP2K4
MAP3K21
MAPK1
MAPK14
MAPK8IP1
MAPK8IP2
MAPK9
NEUROD1
PHB
RAC1
RACGAP1
SH3RF1
SMURF1
TUBB
YWHAE
Entrez ID
6416
4294
HPRD ID
03213
02533
Ensembl ID
ENSG00000065559
ENSG00000130758
Uniprot IDs
P45985
Q02779
PDB IDs
3ALN
3ALO
3VUT
2RF0
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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