MAP3K10 and MAP3K21

Data Source:
BioGRID (two hybrid)

		MAP3K10	MAP3K21
Description		mitogen-activated protein kinase kinase kinase 10	mitogen-activated protein kinase kinase kinase 21
Image
GO Annotations	Cellular Component	Cytoplasm	Cellular_component Cytoplasm
	Molecular Function	Transcription Corepressor Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity ATP Binding Protein Homodimerization Activity BHLH Transcription Factor Binding	Protein Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Homodimerization Activity
	Biological Process	Apoptotic Process Signal Transduction Smoothened Signaling Pathway JNK Cascade Activation Of JNKK Activity Activation Of JUN Kinase Activity Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of JUN Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of JNK Cascade Protein Autophosphorylation	Activation Of MAPKK Activity Protein Phosphorylation Signal Transduction Activation Of JUN Kinase Activity Protein Autophosphorylation
Pathways
Drugs		Fostamatinib
Diseases
GWAS		Birth weight ( 31043758) Resting heart rate ( 27798624)
Interacting Genes		31 interacting genes: ABL2 CDC42 CEACAM1 CLTC CNKSR1 COPS2 DLG4 DNM1 DNM1L GARS1 HGS HTT KIF17 KIF3A KIF3B KIFAP3 MAP2K4 MAP3K21 MAPK1 MAPK14 MAPK8IP1 MAPK8IP2 MAPK9 NEUROD1 PHB RAC1 RACGAP1 SH3RF1 SMURF1 TUBB YWHAE	4 interacting genes: CLK1 MAP3K10 MAP3K11 STUB1
Entrez ID		4294	84451
HPRD ID		02533	10087
Ensembl ID		ENSG00000130758	ENSG00000143674
Uniprot IDs		Q02779	Q5TCX8
PDB IDs		2RF0	4UYA
Enriched GO Terms of Interacting Partners?
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