BHMT and LAMTOR3

Data Source:
BioGRID (two hybrid)

		BHMT	LAMTOR3
Description		betaine--homocysteine S-methyltransferase	late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
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GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Lysosomal Membrane Plasma Membrane Focal Adhesion Endosome Membrane Specific Granule Membrane Extracellular Exosome Tertiary Granule Membrane Ragulator Complex
	Molecular Function	Zinc Ion Binding Betaine-homocysteine S-methyltransferase Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding Kinase Activator Activity Molecular Adaptor Activity
	Biological Process	Sulfur Amino Acid Metabolic Process Protein Methylation Amino-acid Betaine Metabolic Process Amino-acid Betaine Catabolic Process Choline Catabolic Process S-adenosylmethionine Metabolic Process Regulation Of Homocysteine Metabolic Process L-methionine Salvage	MAPK Cascade Activation Of MAPKK Activity Cell Cycle Arrest Regulation Of Macroautophagy Positive Regulation Of TOR Signaling Cellular Protein Localization Neutrophil Degranulation Cellular Response To Amino Acid Stimulus Protein Localization To Cell Junction
Pathways		Sulfur amino acid metabolism Choline catabolism	Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes MAP2K and MAPK activation Neutrophil degranulation Regulation of PTEN gene transcription Amino acids regulate mTORC1
Drugs		Methionine S-(D-Carboxybutyl)-L-Homocysteine
Diseases
GWAS		Betaine levels in individuals undergoing cardiac evaluation ( 26822151) Blood and toenail selenium levels ( 25343990) Blood metabolite levels ( 24816252) Blood trace element (Se levels) ( 23720494) Metabolite levels ( 23823483 23378610) Toenail selenium levels ( 25343990)	Mean reticulocyte volume ( 32888494)
Interacting Genes		6 interacting genes: ALG9 BBS1 BBS2 BBS4 LAMTOR3 LAMTOR5	20 interacting genes: ADAMTS10 APOL6 BHMT CEBPZ CPNE6 IBTK LAMTOR2 MAP2K1 MAP2K2 MAPK1 MAPK3 MBD2 NIF3L1 PDE4DIP QARS1 SUFU TFE3 TGM7 UBR1 ZSCAN4
Entrez ID		635	8649
HPRD ID		04200	04485
Ensembl ID		ENSG00000145692	ENSG00000109270
Uniprot IDs		Q93088 V9HWA4	Q9UHA4
PDB IDs		1LT7 1LT8 4M3P	1SKO 2ZL1 3CPT 5X6U 5X6V 5Y39 5Y3A 6B9X 6EHP 6EHR 6NZD 6U62 6ULG 6WJ2 6WJ3
Enriched GO Terms of Interacting Partners?
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