BHMT and ALG9

Data Source:
BioGRID (two hybrid)

		BHMT	ALG9
Description		betaine--homocysteine S-methyltransferase	ALG9 alpha-1,2-mannosyltransferase
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	Zinc Ion Binding Betaine-homocysteine S-methyltransferase Activity	Alpha-1,2-mannosyltransferase Activity Mannosyltransferase Activity Dol-P-Man:Man(8)GlcNAc(2)-PP-Dol Alpha-1,2-mannosyltransferase Activity Dol-P-Man:Man(6)GlcNAc(2)-PP-Dol Alpha-1,2-mannosyltransferase Activity
	Biological Process	Sulfur Amino Acid Metabolic Process Protein Methylation Amino-acid Betaine Metabolic Process Amino-acid Betaine Catabolic Process Choline Catabolic Process S-adenosylmethionine Metabolic Process Regulation Of Homocysteine Metabolic Process L-methionine Salvage	Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process Mannosylation
Pathways		Sulfur amino acid metabolism Choline catabolism	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes ALG9-CDG (CDG-1l)
Drugs		Methionine S-(D-Carboxybutyl)-L-Homocysteine
Diseases			Congenital disorders of glycosylation (CDG) type I
GWAS		Betaine levels in individuals undergoing cardiac evaluation ( 26822151) Blood and toenail selenium levels ( 25343990) Blood metabolite levels ( 24816252) Blood trace element (Se levels) ( 23720494) Metabolite levels ( 23823483 23378610) Toenail selenium levels ( 25343990)	Asthma or allergic disease (pleiotropy) ( 29785011) Brain morphology (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) Oily fish consumption ( 32066663) Pork consumption ( 32066663)
Interacting Genes		6 interacting genes: ALG9 BBS1 BBS2 BBS4 LAMTOR3 LAMTOR5	2 interacting genes: BHMT H2AX
Entrez ID		635	79796
HPRD ID		04200	09504
Ensembl ID		ENSG00000145692	ENSG00000086848
Uniprot IDs		Q93088 V9HWA4	Q9H6U8
PDB IDs		1LT7 1LT8 4M3P
Enriched GO Terms of Interacting Partners?
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