S100A1 and CAPZA1

Data Source:
HPRD (in vitro)

		S100A1	CAPZA1
Description		S100 calcium binding protein A1	capping actin protein of muscle Z-line subunit alpha 1
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Sarcoplasmic Reticulum Protein-containing Complex	Extracellular Region Cytosol Cytoskeleton F-actin Capping Protein Complex Actin Cytoskeleton Extracellular Exosome WASH Complex
	Molecular Function	Calcium Ion Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity S100 Protein Binding Calcium-dependent Protein Binding ATPase Binding	Actin Binding Protein Binding Cadherin Binding Actin Filament Binding
	Biological Process	Toll-like Receptor Signaling Pathway Regulation Of Heart Contraction Substantia Nigra Development Intracellular Signal Transduction Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Sprouting Angiogenesis	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Blood Coagulation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Actin Cytoskeleton Organization Cell Junction Assembly Interleukin-12-mediated Signaling Pathway Innate Immune Response Barbed-end Actin Filament Capping Protein-containing Complex Assembly
Pathways		Regulation of TLR by endogenous ligand	MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Advanced glycosylation endproduct receptor signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Factors involved in megakaryocyte development and platelet production Factors involved in megakaryocyte development and platelet production
Drugs		Olopatadine
Diseases
GWAS			Blood pressure ( 21572416) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diastolic blood pressure ( 26390057 27841878 28739976 27618452 30487518) Height ( 25282103) Hypertension ( 30487518) Intraocular pressure ( 29617998 29785010) Mean arterial pressure ( 30487518) Mean platelet volume ( 32888494) Platelet count ( 27863252) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878 28739976 27618452 30487518) Total cholesterol levels ( 30275531)
Interacting Genes		30 interacting genes: ACTA1 AGER ANXA6 ATP2A2 BEX3 BIK CACYBP CAPZA1 CEP20 DES FKBP4 GFAP GJA1 MDM2 NIF3L1 PGM1 PLB1 PLEKHF2 PLN PPID PYGM REL RYR1 S100A2 S100A3 S100A4 S100B S100P S100Z SYN1	7 interacting genes: ACTB CD2AP HSPA8 S100A1 S100B SH3KBP1 UCHL5
Entrez ID		6271	829
HPRD ID		01489	03347
Ensembl ID		ENSG00000160678	ENSG00000116489
Uniprot IDs		A0A0S2Z4H2 P23297	P52907
PDB IDs		2L0P 2LHL 2LLS 2LLT 2LLU 2LP2 2LP3 2LUX 2M3W 5K89	1MQ1 1MWN
Enriched GO Terms of Interacting Partners?
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