S100A1 and PGM1

Data Source:
HPRD (in vitro)

		S100A1	PGM1
Description		S100 calcium binding protein A1	phosphoglucomutase 1
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GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Sarcoplasmic Reticulum Protein-containing Complex	Extracellular Region Cytoplasm Cytosol Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Calcium Ion Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity S100 Protein Binding Calcium-dependent Protein Binding ATPase Binding	Magnesium Ion Binding Phosphoglucomutase Activity Protein Binding
	Biological Process	Toll-like Receptor Signaling Pathway Regulation Of Heart Contraction Substantia Nigra Development Intracellular Signal Transduction Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Sprouting Angiogenesis	Carbohydrate Metabolic Process Glycogen Biosynthetic Process Glycogen Catabolic Process Glucose Metabolic Process Gluconeogenesis Glycolytic Process Galactose Catabolic Process Neutrophil Degranulation
Pathways		Regulation of TLR by endogenous ligand	Glycogen synthesis Defective PGM1 causes PGM1-CDG (CDG1t) Neutrophil degranulation
Drugs		Olopatadine	Alpha-D-Glucose 1,6-Bisphosphate Alpha-D-Glucose-1-Phosphate-6-Vanadate
Diseases
GWAS			Alcohol consumption (transferrin glycosylation) ( 21665994) Blood protein levels ( 29875488) Type 1 diabetes ( 32005708 19430480) Type 2 diabetes ( 32499647)
Interacting Genes		30 interacting genes: ACTA1 AGER ANXA6 ATP2A2 BEX3 BIK CACYBP CAPZA1 CEP20 DES FKBP4 GFAP GJA1 MDM2 NIF3L1 PGM1 PLB1 PLEKHF2 PLN PPID PYGM REL RYR1 S100A2 S100A3 S100A4 S100B S100P S100Z SYN1	16 interacting genes: APP DNAJB6 ENO3 HSPB2 KIF1B LINC01554 NLRP3 PAXIP1 PEA15 POT1 S100A1 S100B TERF1 TERF2IP TINF2 USP4
Entrez ID		6271	5236
HPRD ID		01489	01389
Ensembl ID		ENSG00000160678	ENSG00000079739
Uniprot IDs		A0A0S2Z4H2 P23297	B4DDQ8 B7Z6C2 P36871
PDB IDs		2L0P 2LHL 2LLS 2LLT 2LLU 2LP2 2LP3 2LUX 2M3W 5K89	5EPC 5F9C 5HSH 5JN5 5TR2 5VBI 5VEC 5VG7 5VIN 6SNO 6SNP 6SNQ 6UIQ 6UO6
Enriched GO Terms of Interacting Partners?
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