S100A1 and SYN1

Data Source:
HPRD (in vitro, in vivo)

		S100A1	SYN1
Description		S100 calcium binding protein A1	synapsin I
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Sarcoplasmic Reticulum Protein-containing Complex	Synaptonemal Complex Golgi Apparatus Cytosol Cytoskeleton Synaptic Vesicle Postsynaptic Density Axon Dendrite Synaptic Vesicle Membrane Presynaptic Active Zone Schaffer Collateral - CA1 Synapse Extrinsic Component Of Synaptic Vesicle Membrane Anchored Component Of Synaptic Vesicle Membrane
	Molecular Function	Calcium Ion Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity S100 Protein Binding Calcium-dependent Protein Binding ATPase Binding	Actin Binding Transporter Activity Protein Binding ATP Binding Protein Kinase Binding Identical Protein Binding Calcium-dependent Protein Binding
	Biological Process	Toll-like Receptor Signaling Pathway Regulation Of Heart Contraction Substantia Nigra Development Intracellular Signal Transduction Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Sprouting Angiogenesis	Chemical Synaptic Transmission Neurotransmitter Secretion Regulation Of Neurotransmitter Secretion Neuron Development Synapse Organization Synaptic Vesicle Clustering Regulation Of Synaptic Vesicle Cycle Regulation Of Synaptic Vesicle Exocytosis
Pathways		Regulation of TLR by endogenous ligand	Serotonin Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle
Drugs		Olopatadine	Adenosine 5'-[gamma-thio]triphosphate
Diseases			Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS
Interacting Genes		30 interacting genes: ACTA1 AGER ANXA6 ATP2A2 BEX3 BIK CACYBP CAPZA1 CEP20 DES FKBP4 GFAP GJA1 MDM2 NIF3L1 PGM1 PLB1 PLEKHF2 PLN PPID PYGM REL RYR1 S100A2 S100A3 S100A4 S100B S100P S100Z SYN1	30 interacting genes: AMPH BIN1 BLM CAMK1 CAMK2G CDK5 CRK ERG GRB2 ITSN2 KAT5 MAPK3 NOS1 NOS1AP PAK1 PAK2 PAK3 PFN2 PIK3R1 PLCG1 PRKACA RASA1 RB1CC1 S100A1 SNCA SPTAN1 SRC SYN2 SYN3 VIM
Entrez ID		6271	6853
HPRD ID		01489	02433
Ensembl ID		ENSG00000160678	ENSG00000008056
Uniprot IDs		A0A0S2Z4H2 P23297	P17600
PDB IDs		2L0P 2LHL 2LLS 2LLT 2LLU 2LP2 2LP3 2LUX 2M3W 5K89
Enriched GO Terms of Interacting Partners?
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